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Tag: "adenovirus" at biology news

Columbia research lifts major hurdle to gene therapy for cancer

...ells.As an example, the researchers constructed an adenovirus that carriesthe PEG switch and a toxic protein. The switch and the protein wereconnected to each other so that the deadly protein is only unleashedinside cancer cells when the switch is flipped on by PEA-3 or AP-1.When added to a mix of normal and pr...

Live Recombinant Adenovirus Vaccine Technique Explored

...es, a common cause of respiratory infections. Oral adenovirus vaccines have long been proven to be safe and effe...ss for constructing a replicating live recombinant adenovirus could lead to more economical vaccines that provide longer-lasting disease protection, which would b...

Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals

...dely studied vector called a replication-defective adenovirus that readily enters cells but doesn't reproduce itself. Ahrens injected the vector carrying the MRI reporter gene into brains of living mice and imaged the MRI reporter expression periodically for over a month in the same cohort of animals. The resea...

Gene Therapy Cures Inherited Liver Disease In Rats

... needed. The treatment used a specially developed adenovirus to carry the gene into the animal's cells. This viral vector, as it is called, was manipulated so that it minimized toxic side effects. This disease involved a lack of a gene that is found in the part of the cell where detoxification occurs. It point...

Gene therapy cures inherited liver disease in rats

... needed. The treatment used a specially developed adenovirus to carry the gene into the animal's cells. This viral vector, as it is called, was manipulated so that it minimized toxic side effects. This disease involved a lack of a gene that is found in the part of the cell where detoxification occurs. It point...

New vaccine means bye-bye to bacteria in the lung

...nst P. aeruginosa. The researchers use a modified adenovirus vector vaccine expressing a region of the outer me...sponse against P. aeruginosa was boosted. Usually, adenovirus vectors do not allow for repeated infection. These results may be useful in the development of vacc...

Elevated temperature enhances success of viral cancer therapy

...ategies for cancer therapy. ONYX-015 is a mutated adenovirus that undergoes selective replication in tumor cells until the cells become so full of virus that they burst and die. The virus is modified so that it only copies itself in tumor cells and is safe for normal cells. In clinical trials, ONYX-015 was a s...

Gene therapy to lower blood pressure just enough

...lley and his colleagues combines a special kind of adenovirus altered so it does not produce disease connected to a gene regulatory system turned on by the drug mifepristone. Using this vector, O'Malley and his colleagues were able to introduce the ANP gene into the cells of mice. Then tiny doses of drug turne...

Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies

...le. The biphosphonate holds and gradually releases adenovirus particles of the type used to deliver therapeutic genes. In cell cultures, the adenovirus successfully delivered genes from alloy samples to animal arterial smooth muscle cells. In a second ...

Group proves it's possible to grow new lung alveoli by growing new blood vessels

...l maturation, the team attached the proteins to an adenovirus and administered it through an aerosol directly into the lungs. In effect, the virus carried the protein to the heart of millions of lung cells. Once inside the cells, the growth factor proteins went to work doing the job they were programmed to do. ...

Contagious obesity? Identifying the human adenoviruses that may make us fat

...ersity of Wisconsin, Madison, found that the human adenovirus Ad-37 causes obesity in chickens. This finding bui...ccine." "If one could predict the potential of an adenovirus to cause human obesity by using an in vitro assay or even by animal testing, screening of the approx...

Research details how a virus hijacks cell signals to cause infection

...ered a cell receptor called the coxsackievirus and adenovirus receptor (CAR) to which the virus attaches itself. However, the CAR remains below the surface of epithelial cells, in a seemingly inaccessible location called the tight junction. In the new study, Drs. Bergelson and Coyne found that CVBs have evolve...

UC Davis researchers move biotechnology closer to replacing electronic pacemakers

...cemakers like those used in humans and injected an adenovirus carrying a gene encoding for the engineered HCN protein into the heart muscle. Adenovirus has the ability to deliver its own genes into a host cell and hijack its protein-synthesizing machinery. Scientists use this ability to deliver genes of interes...

Targeted virus compels cancer cells to eat themselves

...al of the National Cancer Institute. The modified adenovirus homed in on malignant glioma cells in mice and induced enough self-cannibalization among the cancer cells -- a process called autophagy -- to reduce tumor size and extend survival, says senior author Seiji Kondo, M.D., Ph.D., associate professor in t...

Three-in-one virus killer prevents common, often fatal infections

...ide effects or toxicity. Preexisting therapies for adenovirus have had little success ?there is an 80 percent ch...is no safe and effective therapy for patients with adenovirus infections at the moment, so if you get an infection after a transplant it becomes very problematic,...

Jumping gene could provide non-viral alternative for gene therapy

... patient died because of his immune response to an adenovirus and three children in another study developed leukemia because the virus inserted itself upstream of a cancer-causing gene. "With viruses, you don't have control," says Dr. Kaminski. "People have tried to modify viruses for site-specific integratio...

Gene therapy study takes aim at prostate cancer

...The gene therapy involves attaching an inactivated adenovirus (related to viruses that cause respiratory infections) to the RTVP-1 gene. As the virus infects the tumor cells, it will introduce the gene into the cells as well. (RTVP stands for related to testes-specific, vespid and pathogenesis proteins.) The RT...

Progress made in HIV vaccine development

...nant HIV subtypes, and the second used recombinant adenovirus serotype 5 (rAd5) as a vector to deliver similar H...e response and a replication defective recombinant adenovirus serotype 5 vector to boost responses." ...

Signal protein shows promise for blocking tumor promoters in skin cells

...d Src kinases. Such a therapy would likely use an adenovirus to carry a gene that codes for Srcasm into skin ce...on in skin. Seykora's team has already prepared an adenovirus and mice with the tumor-forming Src kinases expressed in their skin. Within six months, the group ex...

Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer

... Other attempts at gene therapy have employed an adenovirus to deliver the therapeutic gene. "Here we are using a non-viral, non-infectious delivery system," Lu says. The only clinically significant side effect so has been fever, but Lu says premedication with a steroid and diphenhydramine has eliminate...

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