Speeding the search for elusive chromosomal errors
...tments, at least not immediately. In the long run, adds Dr. Shaikh, better knowledge of the underlying genetic cause of a disease may provide targets for designing future therapies. Conventional genetic tests have limited resolving power in detecting many chromosomal arrangements. In karyotyping, chromos...How bad is malaria anemia? It may depend on your genes
... April 24 in the Journal of Experimental Medicine, adds to a growing amount of evidence that an individual's unique genetic makeup can affect the prevalence and outcome of diseases, in this case the individual risk of malarial anemia. A number of human proteins, including MIF (which stands for migration...Recent, rapid climate change is driving evolution of animal species
...se to altered environmental conditions." However, adds Holzapfel, "phenotypic plasticity is not the whole story. Studies show that over the past several decades, rapid climate change has led to heritable, genetic changes in animal populations." Bradshaw and Holzapfel provide a number of examples of the...Potato blight pathogenicity explained by genome plasticity
...rotein that elicits a defense response in plants," adds Govers. "Effectors are quite common in fungal and bacterial plant pathogens, including Phytophthora . But in our case, the gene appears to produce a large regulatory protein that exerts its effect by regulating the expression of other genes, possi...Origen publishes in Nature a robust and versatile method for creating transgenic chickens
...p production through conventional breeding further adds to the practicality of this technology for large-scale production of therapeutic proteins." In the early embryo, only a few cells known as primordial germ cells (PGCs) become sperm or eggs in the adult animal. Previous attempts to culture PGCs from ...Scientists discover new regulating mechanism in cells
...aking process. Normally, that processing step also adds a signal to the mRNA that facilitates the final making of the protein. Because mRNAs like those for junD and the retrovirus are not processed, and therefore lack that signal, scientists have not understood how these mRNAs are translated into protei...New study reveals structure of E. coli multidrug transporter protein
...r laboratory is studying, this new x-ray structure adds another important view of some general structural features across multi-drug resistant transporter families." Other authors of the study include Yong Yin, Xiao He, Paul Szewczyk, and That Nguyen of The Scripps Research Institute. ...Mouse study reveals new clues about virulence of 1918 influenza virus
...ding of the host's response to the 1918 flu virus, adds Dr. Katze, requires use of a fully reconstructed virus. A fuller picture of the host immune response to the 1918 flu virus could also be valuable to scientists working to develop therapies against such viruses as the H5N1 avian influenza, the resea...Mayo Clinic collaboration mining of ancient herbal text leads to potential new anti-bacterial drug
...serve and work with traditional healing cultures," adds Eric Buenz, Ph.D., researcher for Minnesota-based BioSciential, LLC. Ancient Text Rumpf referred to himself as Rumphius, in the Latinized scientific manner of the day. Rumphius was a German-born naturalist who worked for the Dutch East Indies...For super-obese patients, duodenal switch beats gastric bypass
...nce then, to one in 400 U.S. adults in 2000, which adds up to more then 50,000 people in the U.S. At the same time, bariatric or weight-loss surgery has increased from about 16,000 cases in 1992, to 63,000 in 2002, to 171,000 in 2005. The most common surgical procedure for these patients--more than 80 ...Hard-wiring the fruit fly's visual system
...ity refines this map later," he said. The study adds to an ongoing debate about the extent to which brain wiring can be genetically programmed. "We have to be careful when we interpret these results in light of the complexity of the human brain," said Bellen. However, he said, "It is astonishing t...Researchers reveal mystery of bacterial magnetism
... and non-magnetic versions of the same bacterium," adds Professor Bruce Applegate. Professor Applegate directed the genetic engineering at Purdue, with the assistance of Professor Lazlo Csonka, Dr. Lynda Perry, and Ms. Kathleen O'Connor. In the past, scientists had suspected that being magnetic helps ...A new understanding of how cells defend themselves against bacterial pore-forming toxins
... if their function is compromised. Van der Goot adds that a better understanding of the biochemical pathway that allows epithelial cells to survive an invasion by a pore-forming toxin will prove valuable as biomedical researchers try to develop drugs to fight antibiotic-resistant strains of bacteria th...Commercial fishing causes dangerous fluctuations in fish populations
...place those being caught." Professor Beddington adds that the increased variability has serious implications for the way in which fish stocks are managed: "Typically fish populations are managed by governments setting total allowable catch limits (TACs), but a fixed TAC which doesn't take into account ...Emotional control circuit of brain's fear response discovered
...mygdala for a longer amount of time. "This paper adds important regulatory circuit information about the fear response in the amygdala," said Dr. Hirsch. "For example, if someone is walking on an empty street at night and hears a loud banging sound in the near distance, the amygdala would immediately l...Gene chip technology shows potential for identifying life-threatening blood infection
...here a timely diagnosis of infection is important, adds Cobb, who is also professor of surgery and associate professor of genetics. His team's research was published in the November issue of the Journal of the American College of Surgeons. "If someone came into the hospital with a cough and had a worki...Study finds the air rich with bacteria
...es, which is important in bioterror surveillance," adds Eoin Brodie, also with Berkeley Lab's Earth Sciences Division. "A spike may not be due to a biological attack, but to normal weather fluctuations that draw bacteria up from their natural reservoir." In this way, bacterial censuses can help explai...Pleasure and pain: Study shows brain's 'pleasure chemical' is involved in response to pain too
... Now, a new study from the University of Michigan adds a new twist to dopamine's fun-loving reputation: pain. Using sophisticated brain-scanning and a carefully controlled way of inducing muscle pain, the researchers show that the brain's dopamine system is highly active while someone experiences pai...Genomic comparison of lactic acid bacteria published
... extensive bioinformatic analyses by world experts adds to the impact of the genomic data and provides new hypotheses on how microbial genomes evolve by mechanisms of genomic loss and horizontal gene acquisitions." ...Experimental vaccine protects mice against deadly 1918 flu virus
...liest forms of influenza the world has ever seen?" adds Dr. Nabel. "It's because the 1918 flu virus has been reconstructed that we are now able the further understand it. Hopefully, this virus will help us to develop effective vaccine strategies for current pandemic influenza virus threats." To evaluat...