Mouse study reveals human X-SCID gene therapy poses substantial cancer risk
...t an increased risk of developing cancer." Woods adds that the study could explain why one of three children in the French trial developed T-cell leukemia. Two developed the disease because IL2RG inserted itself into the cellular genome next to a known cancer-causing gene and activated it, but the cause...Melanoma vaccine strategy shows promise in laboratory experiments
...ximately a third of all melanoma patients. Herlyn adds that the specificity of the peptide ?the fact that it is found only in melanoma cells, not normal cells ?suggests that the toxicity of any vaccine based on the peptide would be minimal. Killer T cells sparked into action by the vaccine would target o...Marine mammals are on the frontline of failing ocean health
...t policy at the international and national level," adds O'Hara. "Native populations have said, this is our food, our way of life, not just our wildlife." Getting the rest of the world to pay attention to the health of marine mammals may be the first step in mitigating potential human health impacts. "T...Ocean virus identified in human blood samples
...an at Eastern Virginia Medical School. "This study adds to our knowledge of the potential for Vesivirus illness in humans, a potential as-yet unstudied by others," Matson said. There are assays available to test for Vesivirus infection or antibodies, researchers say, that have been developed at OSU and l...Antioxidant selenium offers no heart-disease protection
...ium only as the intervention. However, this report adds important information to our knowledge on the role of selenium in cardiovascular-disease prevention, indicating no overall benefit of supplementation by selenium alone in prevention of cardiovascular disease." ...Malaria parasites develop in lymph nodes
...infection, he noted. Another unexpected finding adds even more complexity to the mammalian immune response to the malaria parasite. An hour after a mouse was bitten, nearly half of the parasites remained in the animal's skin, and some were detected there even after seven hours. "That's really surprisin...New DNA 'fingerprinting' technique separates hemp from marijuana
...he cultivar. Thus, the pattern of fragment lengths adds up to a composite picture of each cultivar. "With this technique, we find hundreds of markers scattered across the genome," said Weiblen. "The larger number of markers, compared to other techniques, gives us the power to separate the cultivars." Th...International HIV/AIDS trial finds continuous antiretroviral therapy superior to episodic therapy
...entify the best approach to treatment management," adds Wafaa El-Sadr, M.D., M.P.H., M.P.A., of the Harlem Hospital Center and Columbia University in New York City, one of the principal investigators for the trial. "We were surprised to learn that in the short term, episodic antiretroviral therapy carries...Researchers solve mystery of how nuclear pores duplicate before cell division
...selves into the nuclear membrane. This discovery adds to the picture of how a cell divides in such a way that the genome (genetic blueprint) encased inside the nucleus can continue communicating with the rest of the cell. "This issue is as important to understanding the cell cycle as is the question of ...Rare Chinese frogs communicate by means of ultrasonic sound
...ples. "That frogs can communicate with ultrasound adds to that list and represents a novel finding, because we normally think such ability is limited to animals equipped with a sophisticated sonar system," he said. "This suggests that there are likely many other examples of unexpected forms of communicat...Common enzyme is a key player in DNA repair
...e DinB translesion polymerase recognizes the G and adds its chemical partner, C, to form the correct base pair in the new chromosome. "It was a pretty striking result," Walker said. "Not only did DinB copy over the damaged G nucleotide, it was 10 to 15 times better at copying the damaged G than copying t...Scientists reveal how deadly toxin hijacks cells
...mong the six most dangerous bioterrorism threats," adds lead author Min Dong, a UW-Madison postdoctoral researcher in the department of physiology. "Knowing the protein receptor for [botulinum toxins] can pave the way for developing anti-toxin reagents which may block the entry of toxins into cells." The...Key heart and Alzheimer's disease protein imaged for first time in native state
...g from the current 10 angstroms to 3.5 or better," adds Weisgraber, who is also a professor of pathology at the University of California, San Francisco. Lipid-bound proteins change their shape once they've bound to a lipid and have begun their key functions. "Until now, we've only been able to model the...Component in soy products causes reproductive problems in laboratory mice
...emale mice that were given the product. This study adds to a growing body of literature demonstrating the potentially adverse consequences of genistein on the reproductive system. "Although we are not entirely certain about how these animal studies on genistein translate to the human population, there is...UC Riverside psychologist explores human perception, finds 'wow factor'
... faces. The ways people's faces move as they speak adds to what we comprehend." The ambient sound in any room also offers more information than people might expect, Rosenblum said. One experiment asked subjects to listen to recorded sounds and try to recognize where on campus the recordings were made. "...New test to detect rare proteins in blood
...n early time when disease can be readily treated," adds Greene. Greene also noted that the FACTT technol...hen women are diagnosed with early breast cancer," adds Greene. "They often have a lumpectomy and are sometimes treated with radiation or chemotherapy, but ...World Trade Center identifications pushed forensic DNA technology
... to Identify the Missing," (Free Press 2005). He adds the staff had "No bar-coding capability, no laboratory information management system . . . to keep track of samples." Worse than a laboratory not ready for the monumental effort of identifying the victims of this disaster were the problems inherent ......ne reactions and makes the system more efficient," adds Pardoll, whose findings are reported in the February issue of Nature Medicine. The Hopkins investigators speculate that the hybrid, dubbed "IKDC" for interferon-producing killer dendritic cell, has been missed by cancer biologists because it is rare......shed in the April 6 edition of the journal Neuron, adds new evidence to the debate over how the brain understands and interprets faces, an area of neuroscience that has been somewhat controversial. Because the process of facial perception is complicated and involves different and widespread areas of the b...