Discovering the first steps in transcription-coupled repair
...ented incision by XPG. To their surprise, however, adding another large protein machine called Transcription Factor IIH (TFIIH) allowed XPG to cut the DNA strand at the appropriate place -- without removing the RNAPII. The best explanation is that TFIIH causes a conformational change, a "remodeling" of the ...Novel enzyme offers new look at gene regulation
...does not have LSD1, although it does have proteins adding methyl groups to histones." Zhang devised a biochemical strategy to isolate proteins that could remove methyl from histones inside a test tube. The result was the identification of a novel protein, JHDM1A, named for JmjC histone demethylase 1A. A si...Brain activity related to processing faces is similar in people with, without autism
...e, gaze direction in this instance," Dichter said, adding that most such studies did not account for where the participants fixed their gaze during brain scanning. Because individuals with autism typically choose to look away from faces, the previous studies could not disentangle the effects of a preferen...Underlying cause of massive pinyon pine die-off revealed
...t, the recent drought was hotter," Breshears said, adding that, if anything, the 1950s drought was drier. The high heat combined with the extreme dryness put the trees under so much water stress that the attacks from bark beetles finished them off. Under such conditions, the trees cannot make enough pine s...New technique multiplies life span in simple organisms
...ollege of Letters, Arts and Sciences. Rather than adding copies of SIR2 to yeast, Longo's research group deleted the gene altogether. The result was a dramatically extended life span - up to six times longer than normal - when the SIR2 deletion was combined with caloric restriction and/or a mutation in on...Storing carbon to combat global warming may cause other environmental problems, study suggests
...calyptus, he added. However, the researchers said adding more of these plantations would also release more moisture into a region's atmosphere, as trees roots removed water from the soils and discharged some portions as water vapor emanating through leaf pores. To predict whether this increased moisture ...Delaware scientists make significant advance in study of small RNAs
...so provides quantitative information," Green said, adding that "this allowed many highly regulated small RNAs to be identified." In addition to the sheer number of sequences identified, Meyers said "the biggest surprise in the findings is the diversity." He said that their data indicated that the regions o...Student scientists create living bacterial photographs
...t, first engineered the bacteria to sense light by adding a light receptor protein from a photosynthetic blue-green algae to the E. coli cell surface. They hooked the light receptor up to a sensor in E. coli that normally senses salt concentration. Instead of sensing salt, the bacteria could sense light. T...Building a better mouse model of lung cancer: FHIT counts
...urrent model will only make it stronger, she says, adding they're already working on it. Other Ohio State researchers who contributed to the study include Nicola Zanesi, adjunct assistant professor and research scientist, George Calin, adjunct assistant professor, and Yuri Pekarsky, assistant professor, al...New molecule may aid in production of biofuels and fungi-resistant plants
...ble to degradation by chitinases. They showed that adding CBP21 dramatically speeds up the degradation of chitin by chitinases. CBP21 works by binding to chitin through highly specific interactions that disrupt the chitin structure making the individual sugar chains in the chitin polymer more amenable to en...Fresh water affected by salt from deicing roads
...of deicing that occurs is increasing and gradually adding salt to fresh water systems reports Sujay Kaushal and colleagues in the September 2005 issue of the Proceedings of the National Academy of Sciences. The scientists used historical records over the last 30 years and direct measurements to quantify...Living anti-HIV gel shows early promise
...inst harmful organisms. The researchers hope that adding modified bacteria to these existing microbes could help prevent HIV transmission, especially in developing countries. They point out that if the bacteria successfully colonise and reproduce, protection can be long-lasting. Short-lasting creams again...Biotechnology's newest chemical tool
...f the tools cells use to turn genes on and off. By adding a simple cluster of four atoms -- a carbon atom attached to three hydrogens, known to chemists as a methyl group -- to specific bases within a DNA sequence, methyltransferases can effectively shut a gene off. Methylation plays an important role in em...DNA size a crucial factor in genetic mutations, study finds
...-called an analog-and made five different sizes by adding increasingly larger atoms. The first analog was smaller than natural thymine, the second about the same size and the last three were increasingly larger. The difference between the smallest and largest analogs was only one angstrom, or a tenth of a n...Costly breeding programs for endangered species pay off
...cores. The release into the wild was simulated by adding environmental stress. In the "post-release" breeding scenario, temperatures in incubators were altered on a 12-hour cycle based upon the high and low temperatures recorded in Houston that day. In both strategies, all breeding lines survived in capti...Scientists and engineers apply nature's design to human problems
... explained. "We're talking about augmenting it and adding to its functionality and activity. We used the analogy of a new species trying to fit into a community as a way to think about what our center could do to increase the productivity of the Tech 'ecosystem.'" As CBID encourages interaction among its i...UNC scientists discover new role for protein as fundamental inhibitor of cell movement
... PAK1, this kinase then inhibits cell migration by adding a phosphate group to a host of other proteins in the cell. Thus, the study suggests that CIB1 may be a likely target for new drug development aimed at decreasing tumor metastasis, or spread, throughout the body. "I was ecstatic to see these results...FDA: 'Highly Unlikely' Green Tea Lowers Cancer Risk
...ng refined interventions very precisely," he said, adding that "the ultimate potential for the system, if the instruments can be made small enough, would be its use in fetal surgery, in utero." Since the arrival of the da Vinci robot at UNC Hospitals in early 2005, several successful "robotic-assisted lapa...Screen all at risk for HIV, plus pregnant women
...ng refined interventions very precisely," he said, adding that "the ultimate potential for the system, if the instruments can be made small enough, would be its use in fetal surgery, in utero." Since the arrival of the da Vinci robot at UNC Hospitals in early 2005, several successful "robotic-assisted lapa...Surgical Robot 'Scrubs In' At UNC, May Be More Precise Than Conventional Surgery
...ng refined interventions very precisely," he said, adding that "the ultimate potential for the system, if the instruments can be made small enough, would be its use in fetal surgery, in utero." Since the arrival of the da Vinci robot at UNC Hospitals in early 2005, several successful "robotic-assisted lapa...