Weighting cancer drugs to make them hit tumors harder
... The scientists increased the size of the drug by adding a "macromolecular weight" that increases its conce...are fully achieved. Overcoming this limitation by adding macromolecular weight is not a new concept, but determining the precise weight to achieve optimal dr...MIT researchers build tiny batteries with viruses
...o previously used battery electrode materials. And adding the gold further increased the wires' energy density, she added. Equally important, the reactions needed to create nanowires occur at normal room temperatures and pressures, so there is no need for expensive pressure-cooking technology to get the jo...Study fishes out new role for prostaglandins
... to stop the process. DuBois previously found that adding PGE2 to cultured cancer cells causes them to move much more rapidly. "We've been able to show that some genes in this pathway are really important for cancer cells to spread to the liver," he said. "Eventually, we may be able to find a way to attack...Study may help slay 'Yellow Monster'
... students are not only gaining knowledge, they are adding to that knowledge with new discoveries about uranium. The fact that uranium, as a radioactive metal, can damage DNA is well documented. But what Stearns and her collaborators recently have found is that uranium can also damage DNA as a heavy metal, ...Stable polymer nanotubes may have a biotech future
...y.) The researchers made the membranes stretchy by adding a soap-like fluid to change the polymer membranes' mechanical properties. Then they used "optical tweezers" (highly focused infrared lasers) or tiny droppers called micropipettes to pull on the elastic membranes to form long, double-walled tubes that...Brain's own cannabis compound protects against inflammation
...rease in AEA levels. Importantly, they found that adding AEA to such damaged brain tissue abolished inflammatory damage to the brain cells, but did not reduce the primary "excitotoxic" damage from the chemical. They found similar effects of AEA when they damaged the brain tissue by depriving it of oxygen a...Contaminants linked to sturgeon decline in Columbia river
...t in the sediment as the water slows," Feist said, adding that at this point this is a hypothesis. "Fish residing in the reservoir behind the oldest dam had the highest contaminant loads," Feist added, "and exhibited reduced growth and reproductive fitness when compared to fish sampled in other locations. ...Paleontologists learn how not to become a fossil
...o correct the record numerically," Jablonski said, adding back the missing varieties in their expected proportions. The fossil record of other organisms could be assessed in much the same way, Jablonski said, producing a clearer picture of the biological dynamics of the past. "The gauntlet is down: look a...Alzheimer's found to be mostly genetic
...ne has had this large a sample before," Gatz said, adding the size was 10 times that of any previous study. The study raises doubts about the widely held view that Alzheimer's has two forms: the "familial," with genetic roots, and the "sporadic," with environmental causes. "In essence what we're doing is ...Gut protein found to protect against infection and intestinal breakdown
... off, preventing bile from reaching the intestine, adding GW4064 prevented damage to the intestines, showing that it can replace bile in protecting the small intestine. Genetically engineered mice that lacked FXR showed overall damage to the intestines, "strong evidence that this protein is crucial," Dr. ...New antimicrobial compound adheres to skin to promote healing
..., cleanse the wound and promote healing," he said, adding that they're also looking at a non-oily gel formulation for use as a combination cleanser and ointment for killing acne-causing bacteria. ...Therapeutic prospects beyond Vioxx
...investigators also addressed the likely benefit of adding aspirin to diminish this effect of the inhibitors. Surprisingly, this appeared to reduce not only the clotting response, but also the rise in blood pressure caused by drugs like Celebrex. "Despite some chatter to the contrary, this issue of an aspir...Medieval diaries aid scientists ascertain increase in hot spots due to global warming
...the last century compared to the past 1200 years - adding to the growing evidence of wide-scale global warming. Dr Tim Osborn and Prof Keith Briffa, of the Climatic Research Unit team at the University of East Anglia, analyzed thermometer measurements of temperature from 1856 onwards to establish the spati...Morning grogginess more debilitating than sleep deprivation, according to CU-Boulder study
...ipants were given a performance test that involved adding randomly generated, two-digit numbers, said Wright. Based on the results, the researchers concluded the subjects exhibited the most severe impairments from sleep inertia within the first three minutes after awakening, he said. The most severe effec...Bioactive cement scaffold may improve bone grafts
..., a calcium phosphate material, is strengthened by adding chitosan, a biopolymer extracted from crustacean shells. The implant is further reinforced to about the same strength as spongy natural bone by covering it with several layers of a biodegradable fiber mesh already used in clinical practice. "Bone ce...New gene reduces retinal degeneration in fruit flies
... molecules exert their control remains unclear. In adding the Lazaro gene to the list of players, the researchers hope to learn more about how TRP channels are controlled. ...Polymer aids in blood clotting, pointing way to new treatment
...ate and postdoctoral students tested the effect of adding polyphosphate to platelet-poor plasma in a series ...otting. The results were dramatic, Morrissey said, adding that the presence of polyphosphate may help explain how platelets accelerate the process of blood cl...New cellular flaw found in some virulent breast cancers
...ould pave the way to new therapies, says Sicinski, adding that while it would be difficult to design a drug to inhibit the action of a protein like cyclin D1, blocking a kinase is significantly easier. ...Potential vaccine developed for deadly leishmaniasis disease
...ne response. Vaccine manufacturers achieve this by adding a booster substance ?an adjuvant. The standard existing adjuvant, alum, has limitations. Potential alternative adjuvants are toxic, expensive or have other problems. Seeberger’s candidate vaccine combines the delivery vehicle, immune-stimulating ant...... or destabilize it, either by heating it up, or by adding solvents to the system, like urea for example, that just destroy the folded structure of the protein. How resilient the protein is to these assaults is what we often call stability," de Pablo says. "Detergents like the ones you use to wash your cloth...