New engineered drug may offer prolonged arthritis relief
...leading cause of disability, the researchers said, adding that as the average age of the population continues to rise, the incidence of osteoarthritis will increase. Osteoarthritis had been attributed primarily to the gradual wear and tear of joint surfaces. More recently, however, scientists have discove...Chemical tests of cell growth enter third dimension
...ing cells to fluoresce. Researchers test a drug by adding it to a well. If the cells continue to fluoresce, that means that the cells are still reproducing, and the drug isn't effective at controlling growth. The problem is how to measure the amount of fluorescence, to quantify how much the cells are growi...Pressured by predators, lizards see rapid shift in natural selection
...ently caused this remarkable reversal, Losos says, adding that behavioral flexibility may often drive extremely rapid shifts in evolution. "Evolutionary biology is by its nature an historical science, but the combination of microevolutionary experimentation and macroevolutionary historical analysis can p...UCSD researchers create roadmap to integrin activation
... throws the activation switch," Ginsberg said. "By adding controllable amounts of talin and the enzyme prote...ists engineered an integrin-activated pathway. By adding protein kinase C, talin or mutants to manipulate the system, they hope to define and map sites where...How brain injury leads to seizures, memory problems
...Ph.D., of The Children's Hospital of Philadelphia, adding that, "TBI is the leading cause of death among children and young adults in this country. There are no cures known for traumatic brain injury. Our hope is that our research may contribute to potential therapies for TBI patients." Transportation ac...Therapeutic role found for carbon monoxide
...was crucial for the positive CO effects," he says, adding that studies are now underway to determine the mechanism by which CO exposure leads to the increase in NO generation. "Our hope is that CO will find a place in the clinic as a therapeutic option for the treatment of disease," concludes Otterbein. "C...Reading Shakespeare has dramatic effect on human brain
...spearean language excites positive brain activity, adding further drama to the bard's plays and poetry. Shakespeare uses a linguistic technique known as functional shift that involves, for example using a noun to serve as a verb. Researchers found that this technique allows the brain to understand what a ...A human taste for rarity spells disaster for endangered species
...a new theoretical study in PLoS Biology shows that adding human behavior to the equation--specifically, the human penchant for rarity--reveals an unexpected mechanism of exploitation, with alarming implications for species survival. Franck Courchamp, Elena Angulo, and their colleagues incorporated the assu...Halving daily cigarette quota has no health benefit
...d again twice at an interval of three to 10 years, adding up to an average monitoring period of over two decades. Participants were classified as never smokers; ex smokers, quitters (those who gave up between the first and second check); moderate smokers (1 to 14 cigarettes daily); reducers (more than 15...Melatonin improves mood in winter depression
...ly phase-delayed type of patient," explained Lewy, adding that more research is needed. Lewy is the Richard H. Phillips Professor of Biological Psychiatry, senior vice chairman of psychiatry, and director of the Sleep and Mood Disorders Lab, OHSU School of Medicine. ...Scientists use gene signatures to match cancer and other diseases with potentially effective drugs
...some cell lines it appears that it does," he said, adding that a clinical trial is being planned to try rapamycin in children who have had recurrences of initially successfully treated ALL. Moreover, the comparison of gene signatures revealed that rapamycin's effectiveness was due in part to its action on...Analysis of breast-cancer gene role offers promising target
...fectiveness of the drug trastuzumab (Herceptin) by adding a second drug seeking to neutralize the uPAR gene. "One major avenue of investigation would be to develop an antibody that prevents uPAR from binding to a molecule called uPA that can activate uPAR," Dr. Uhr said. ...Mobile DNA part of evolution's toolbox
...troposons can generate evolutionary experiments by adding new regulatory modules to genes. Most of these experiments will have no effects or will harm an organism. But every once in a while, the movement of a regulatory element will give an organism an evolutionary advantage. "And to the extent that [such c...Mutant mice show key autism traits
...n complex and mysterious, researchers are steadily adding pieces to its intricate puzzle. In what they believe to be a significant new approach to understanding "autism spectrum disorders" (ASD), researchers have developed a mouse that shows abnormal social interactions and brain hypertrophy characteristic ...Ozone recovering, but unlikely to stabilize at pre-1980 levels, says study
...1 shuttle model' no longer made sense," says Vert, adding that it took many carefully designed experiments to convince himself and others that it was time to retire the old model. A new picture of how brassinosteroids stimulate plant growth now emerges based on those experiments: steroid hormones are still...Salk scientists untangle steroid hormone signaling in plants
...1 shuttle model' no longer made sense," says Vert, adding that it took many carefully designed experiments to convince himself and others that it was time to retire the old model. A new picture of how brassinosteroids stimulate plant growth now emerges based on those experiments: steroid hormones are still...Gene therapy prevents the onset of diabetic symptoms in mice
...searchers found. They drew these conclusions after adding nutrients to soil in a test plot and reproducing the favorable soil conditions that existed prior to 20th century industrial pollution. The result: Sugar maples on the plot rebounded dramatically. The study provides "the most conclusive evidence to ...Acid rain causing decline in sugar maples, say researchers
...searchers found. They drew these conclusions after adding nutrients to soil in a test plot and reproducing the favorable soil conditions that existed prior to 20th century industrial pollution. The result: Sugar maples on the plot rebounded dramatically. The study provides "the most conclusive evidence to ...Orange, grapefruit juice for breakfast builds bones in rats
...f testosterone decreases as men age," said Deyhim, adding a similar study on female rats has begun. Deyhim said fresh grapefruit or orange juice - mixed with sodium bicarbonate to neutralize acidity - was given to the rats each morning. "They drank it with no problem, every morning," Deyhim said. "They dr...Surprising symbiosis: Glassy-winged sharpshooter eats with friends
...ould there be something else, some other bacteria, adding these essential ingredients? Yes. Realizing the amino acid pathways might be carried out by other bacteria living inside the insect, the team began picking through their forensic samples of DNA sequences, removing all the sequence reads that matche...