FDA causes unnecessary scare about common painkillers
... an unnecessary scare about some pain relievers by adding a warning to drugs that are safe, says Curt Furber... that should be taken off the market. "The FDA is adding 'black box' warnings to all prescription and over-the-counter pain relievers ?even to naproxen ?whic...Ultrathin films deliver DNA as possible gene therapy tool
...ring method, they can control the amount of DNA by adding more layers, or can even layer multiple ingredients in a specific order. Tweaking the polymer structure slightly can change how quickly the films erode and thus how long cells are exposed to the gene therapy. "We ultimately need an effect prolonged...Nanoparticles can track cells deep within living organisms
... the labeled cells would reveal that the tumor was adding new blood vessels and therefore aggressively growing. Adult stem cells are also under investigation in therapies that enhance new blood vessel growth to improve the blood supply to diabetic patients' limbs or to repair blood vessels after a heart...Interaction between lymph and liver cells may affect immune response
...ripheral non-lymphoid tissues," the authors state, adding that the study furthers the notion that liver cells may be involved in hepatic immune tolerance. "Like any good study," they conclude, "the work of Warren et al., answers important questions but also raises some new and intriguing areas for further e...Growth factor stimulates rapid extension of key motor neurons in brain
... showed that two ways of applying IGF-1 ?generally adding it to culture dishes or placing IGF-1-coated microbeads right next to CSMN cell bodies ?both increased the growth of axons by 15- to 20-fold, reaching the very fast rates previously seen only during initial development. Blocking the interaction betw...Unique gene regulation gives chilly bugs survival advantage at bottom of the world
...ving on the continent year-round," said Denlinger, adding that other native animals, such as seals and penguins, spend much of their time in the water. The midge is also the only insect known to inhabit Antarctica. He and his colleagues collected adult and larval midges during field study tours to Antarct...Living view in animals shows how cells decide to make proteins
...en from day to day as an animal develops, he said, adding that extracting cells and watching them in a culture cannot convey all of these transient changes. Moreover, different cell types within the brain or other organs can exhibit different splicing decisions, Garcia-Blanco said. For example, neurons r...Science researchers genetically transform immune cells into tumor fighters
...ert them to tumor-reactive cells," Rosenberg says, adding that the engineered cells could be tailored to fight tumors other than melanoma. "We've identified T cell receptors that will now recognize common cancers," he notes. The newly engineered T cells showed signs of persistence in 15 of the patients in...Molecules in blood foretell development of preeclampsia
...ve reducing levels of sFlt1 or soluble endoglin or adding more of the molecules that they remove from the blood stream, Dr. Levine added, so that more VEGF, PlGF, and TGF beta would be available for the blood vessels that need them. One company has developed the means to produce a form of VEGF. Presumably...Nature's process for nitrogen fixation caught in action
...n nitrogen gas (N2) and ammonia (NH3) that require adding electrons and protons." In order to trap the process at a specific stage, the researchers synthesized a mimic of an intermediate compound in the pathway, and then followed its progress. The PNAS article talks about the challenge of identifying, t...BC catalyst discovery promises faster, cheaper drug production
...o take four to five steps to accomplish ?each step adding significantly to the final cost ?can now be achieved in a single transformation. The substance also contains no metals and is therefore more environmentally friendly than many other catalysts. "The new catalyst is easy to prepare, requires little o...Mysterious 'neural noise' actually primes brain for peak performance
...that while multiplying large numbers is difficult, adding them with log tables is relatively undemanding. The brain is apparently designed in a similar manner--"coding" the possibilities it encounters into a format that makes it tremendously easier to compute an answer. Pouget now prefers to call the n...Mayo researchers discover HIV dependence on a human protein
...V. Adding back p75 made them vulnerable again. And adding a "dominant-negative" piece of p75 to the mix, a sort of molecular spanner in the works, further impaired the virus (over 500-fold). Moreover, the Mayo team showed that each "knot" of the molecular tether was necessary, defining the mechanism in a w...Detailed 3-D image catches a key regulator of neural stem cell differentiation in action
... Enzymes called kinases turn the "light" on by adding small phosphate chemical groups - giving RNA polymerase the go-ahead to transcribe genes - while removal of those phosphates by phosphatases like Scp1 turns out the light, effectively stopping RNA polymerase in its tracks. Noel and postdoctoral f...Powerful genome ID method extended to humans
...to detect" by conventional sequencing, Green said, adding that sequencing can simply miss part of a genome. Optical mapping, by contrast, can estimate the absolute length of a genome and quickly detect differences in length and structure between two genomes. Comparing optical maps of healthy and diseased...Taking 'chips' to the next level of gene hunting
...the top and bottom layers. Next we're going to try adding another layer reading diagonally" to triple the amount of genomic information packed onto the tiny chips. ...Sandia researchers discover way to see how a drug attaches to a cell
... become active and catalyze the dendrite growth by adding more platinum atoms from the platinum salt. Little by little, small, flat, platinum dendrites form within the double lipid layer. "The important thing is to make sure that the number of photocatalyst molecules - and thus the number of platinum cl...Replacing insulin is top-ranked breakthrough foreseen for health in developing world
...ic kidney disease and diabetic ulcers, they noted, adding that repeated insulin treatments are costly and therefore inaccessible to many developing country patients. The 2nd-ranked application, regenerating failed heart muscle using the patient's own cells, is being successfully tested in several countri...Did 'ABCs' cause Uganda's fall in HIV rates?
...lement its wide-ranging HIV prevention program and adding gender-related elements when it became clear that this strategy was necessary." In Uganda, they say, policies to advance women's status were part of the ABC strategy. "In the context of Uganda's political leadership, nationwide social mobilization ...Researchers discover mechanism that determines when detailed memories are retained
... for learning and memory, appears to be the key to adding details to a memory. In a study with rats, Norman Weinberger, research professor of neurobiology and behavior, and colleagues determined that a higher level of acetylcholine during a learning task correlated with more details of the experience being ...