Enhancing activity of marijuana-like chemicals in brain helps treat
...keep the inhibitory pathway in check. When they added a drug that slows the enzymatic breakdown of endocannabinoids in the brain - URB597, being developed by Kadmus Pharmaceuticals in Irvine, Calif. - the results were striking. "The dopamine drug alone did a little bit but it wasn't great, and the...ConocoPhillips establishes $22.5M biofuels research program at Iowa State
...ents in the first year with additional researchers added in subsequent years. He noted that ConocoPhillips turned to Iowa State as a research partner, in part, because of Iowa State's expertise in a wide range of biorenewable technologies. Iowa State's Office of Biorenewables Programs includes 145 facul...Hybrid molecule causes cancer cells to self-destruct
...e been disappointing because the molecular partner added to butyrate to improve delivery to the cancer cell... formulas and the butyrate-ManNAc hybrid were each added to lab dishes containing cancer cells. After three to five days, cancer growth had slowed in all of ...Misusing vitamin to foil drug test may be toxic; plus, it doesn't work
... the daily recommended dose of niacin." Dr. Mittal added that there is a report in the medical literature of a patient who suffered liver failure, requiring a liver transplant, after taking excessive doses of niacin. Many Internet sites promote the misconception that niacin can be used to pass urine dru...3 proteins may play important role in nerve-cell repair
...nvolvement in cAMP regulation. The researchers added additional copies of the three genes to the cells to increase the levels of the proteins, and then used a laboratory technique called RNA intereference to turn off production of the proteins. Of the three molecules, GPR3 was the most abundant in ...Common gene version optimizes thinking -- but with a possible downside
...efrontal cortex is impaired, as in schizophrenia," added Daniel Weinberger, M.D. "Normally, enhanced cortex... and substance abuse as well as to schizophrenia," added NIMH Director Thomas Insel, M.D. To understand DARPP-32's role in the human brain, the NIMH rese...Robotic exoskeleton replaces muscle work
...'s gait was disrupted because the mechanical power added by the exoskeleton made the muscle stronger. However, in a relatively short time, the wearers adapted to the new strength and used their muscles less because the exoskeleton was doing more of the work. Their gait normalized after about 30 minutes. ...A new study of living cells could revolutionize the way we test drugs
...any self-respecting party-goer would: alcohol. "We added ethanol ?which is essentially vodka ?to provoke a ...ng cell," says Professor Geim. The researchers had added so much ethanol that it poisoned the cell. Although not the cardiogram they had hoped for, the el...Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps
...researchers a perspective to observe what has been added or deleted in each primate genome during evolution of rhesus, chimp, and the human from their common ancestors ," said Richard Gibbs, Ph.D., director of Baylor College of Medicine's Human Genome Sequencing Center in Houston and the project leader. ...Link found between immune system and high plasma lipid levels
...ase, often associated with elevated lipid levels," added co-author Godfrey Getz, MD, PhD, professor of pathology, biochemistry and molecular biology at the University of Chicago. "This study may explain why. The next step would be to determine whether we can use this technique to manipulate the immune resp...New technologies coming too fast for Indian farmers
The arrival of genetically modified crops has added another level of complexity to farming in the developing world, says a sociocultural anthropologist at Washington University in St. Louis. Glenn D. Stone, Ph.D., professor of anthropology and of environmental studies, both in Arts & Sciences, at...Chemo combination improves survival in asbestos-related cancer
...oth incidence and severity after the vitamins were added to the treatment. People who work trades such as shipbuilding, railway engineering, construction work and asbestos manufacture have higher rates of mesothelioma than the general public. The cancer may take 10 to 60 years to develop, and the risk does...Grape expectations for healthier wine
...ing process to produce healthier wines without the added sulphites that can cause asthma and other conditio...akers have a similar problem in that the sulphites added to wines to prolong their shelf-life and allow them to age can make their wines unpalatable to some ...Fighting to keep Darwin in the classroom
...nd more. The full-color online edition will offer added value, for example chat rooms, teaching resources and blogging opportunities. In addition, Springer has committed up to $10,000 annually in grants and prizes for the best paper, the best lesson plan, etc. The journal, aimed at members of the educati...Researchers discover gene crucial for nerve cell insulation
...ought to involve myelin production. Dr. Svaren added that it is possible that the current study's findings about myelin production in the peripheral nervous system could lead to greater understanding of how myelination takes place in the central nervous system (the brain and spinal cord). Myelination i...Destructive enzyme shows a benevolent side
...question, they used cultured cells to which they'd added active and mutant forms of the enzyme. They then stressed the cells using the chemical arsenite, a relative of arsenic. The investigators found that during stress, the enzyme interacts directly with another protein called TIA-1, a key protein invo...New biofuels process promises to meet all US transportation needs
...od called electrolysis. Then the hydrogen would be added during the gasification step, making the process more efficient by suppressing the formation of carbon dioxide and converting all of the carbon atoms to fuel. When conventional methods are used to convert biomass or coal to liquid fuels, 60 percen...Gene that makes people 'early to bed and early to rise' demystified
... mice," which lack the Per2 clock gene altogether, added study author Ying-Hui Fu, who is also at UCSF. Based on those studies, "everybody had thought a short or long period depended on a change in protein stability," she said. "That's how we thought the system should work. But this paper shows that is ...Researchers create artificial enzyme that mimics the body's internal engine
...orm oxygen into water. "How all four electrons are added to oxygen has always been mysterious," Collman said. "Very few people study it. It's quite complex, and it's been broadly ignored." Each electron is brought to the enzyme one at a time, Collman said: "It's like a bucket brigade in a Western movie.......ne in rodents and probably humans, too." Grandy added that it's his hope that "these findings will eventually lead to the development of new pharmaceuticals that reduce dependence on and craving for methamphetamine." The study is published in the April edition of the Journal of Pharmacology and Exper...