Secret of smallpox's success may lead to bioterror cure
...pox virus, the effectiveness of the vaccine cannot actually be tested through clinical trials on humans. Instead, the vaccine is tested on mice and other animal models, using viruses closely related to smallpox that are lethal to those animals. "We're testing with vaccinia and mousepox in lab mice, and in do...Disease progression model of pancreatic cancer developed by Penn researchers
...uppressor pathways, Hingorani suggests, "there may actually be unique genetic routes to pancreatic cancer, such that not all pancreatic cancers are equivalent." The development of the first animal model for pancreatic cancer that fully imitates the progression of the human condition will likely open many new...New polysaccharide may help combat multidrug resistance in cancer
...lay a purely structural and inert role in cells is actually involved in multidrug resistance in cancer. Using antagonists for this molecule, the researchers were able to sensitize drug resistant breast cancer cells to chemotherapeutic drug treatment. The research appears as the "Paper of the Week" in the May...Low oxygen likely made Great Dying worse, greatly delayed recovery
...r. However, it appears the greatly reduced oxygen actually created impassable barriers that affected the ability of animals to move and survive, he said. "If this is true, then I think we have to go back and look at oxygen and its role in evolution and how different species developed," Ward said. "You can g...Scientists reveal the shape of a protein that helps retroviruses break into cells
...r. However, it appears the greatly reduced oxygen actually created impassable barriers that affected the ability of animals to move and survive, he said. "If this is true, then I think we have to go back and look at oxygen and its role in evolution and how different species developed," Ward said. "You can g...Designing vaccines by computer
... that we don't have to know what a foreign protein actually does in order to identify it as having fragments that that could make good vaccines. This approach has the potential to significantly reduce the number of proteins that we need to experimentally test to develop new vaccines to protect both humans and...Too much water may be as dangerous as too little during long-distance athletic events
...y found a surprisingly large number of runners had actually gained weight during the race and their sodium concentrations were very low - some were dangerously low," Dr. Levine said. "The recommendations listed in the study that fluid-replacement schedules be individualized for all athletes competing in long-...Bush, Cheney and Rumsfeld are now species of slime-mold beetles -- but strictly in homage
...y found a surprisingly large number of runners had actually gained weight during the race and their sodium concentrations were very low - some were dangerously low," Dr. Levine said. "The recommendations listed in the study that fluid-replacement schedules be individualized for all athletes competing in long-......y found a surprisingly large number of runners had actually gained weight during the race and their sodium concentrations were very low - some were dangerously low," Dr. Levine said. "The recommendations listed in the study that fluid-replacement schedules be individualized for all athletes competing in long-...Stealth Worms May Improve Insect Pest Control
...c bacteria. "We study these nematodes -- which are actually insect killers -- not only to understand how diverse they are, but also to use them as biological control alternatives," says Patricia Stock, a nematomologist in the University of Arizona College of Agriculture and Life Sciences. "We want to see how...Molecular thermometers on skin cells detect heat and camphor
...s the TRPV3 proteins on the keratinocytes that are actually detecting warm temperatures. It is not known how this signal is communicated to the brain, since keratinocytes, unlike neurons, have no direct link with the central nervous system. Keratinocytes do, however, touch nerve fibers, and it may be through ...Future diabetes drugs may target new protein interaction
... proteins best known for very different activities actually come together to turn the liver into a sugar-produ...e for Basic Biomedical Sciences. "The two proteins actually bind to each other, and without sirtuin1, PGC1 can't make glucose." A current diabetes-fighting dru...... proteins best known for very different activities actually come together to turn the liver into a sugar-produ...e for Basic Biomedical Sciences. "The two proteins actually bind to each other, and without sirtuin1, PGC1 can't make glucose." A current diabetes-fighting dru...Sugar beet virus mutation requires Texas touch
...as purifying the virus and quantifying how much is actually present, they can determine if resistance is expressing itself, Rush said. Breeders have good indications they may have some resistance in some wild relatives of sugar beets, he said. Advanced lines identified with potentially high levels of resista...Computational verification of protein-protein interactions by orthologous co-expression
... proteins best known for very different activities actually come together to turn the liver into a sugar-produ...e for Basic Biomedical Sciences. "The two proteins actually bind to each other, and without sirtuin1, PGC1 can't make glucose." A current diabetes-fighting dru...Eliminate Data Analysis Bottlenecks in Drug Discovery
... proteins best known for very different activities actually come together to turn the liver into a sugar-produ...e for Basic Biomedical Sciences. "The two proteins actually bind to each other, and without sirtuin1, PGC1 can't make glucose." A current diabetes-fighting dru...Remote control flies? Fly behavior controlled by laser light
...mote control system. "To ascertain that the system actually worked, it wasn't clear how we could measure activation in the neurons in moving, freely behaving organisms," he explains. The breakthrough, he says, came when they decided to target a small set of nerve cells in the fly called the giant fiber syste...Leprosy genome tells story of human migrations, French researchers report in Science
...is, but the new findings indicate that the disease actually originated in East Africa or perhaps the Near East, then migrated eastward and westward. Europeans and North Africans then spread Leprosy to West Africa, and the slave trade brought the disease from West Africa to the Caribbean and South America, th...Tsunami-damaged coral reefs should be left to recover naturally, say scientists
...ld not be a good use of scarce resources and could actually harm surviving reefs. We need to find a long-term, sustainable solution for restoration. "We're advocating a cleaning up of the debris in the majority of cases, so as to allow natural recovery processes to take place. Coral reefs have been subject to...Mice brains shrink during winter, impairing some learning and memory
The brains of one species of mouse actually shrink during the winter, causing the mice to have more difficulty with some types of learning, a new study found. The results showed that, during the short days of winter, white-footed mice had impaired spatial memory ?the mental map that helps the...