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Tag: "active" at biology news

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

...In combination with other cancer genes, hTERT, the active protein in the enzyme telomerase, caused progressi...elopment of melanoma. They found the expression of active PI3K, together with CDK4, hTERT, and inhibition of p53, produced invasive melanoma growth indistingu...

The synapse is a shotgun

...neurotransmitter is released only from vesicles in active zones, where everybody thinks it is released, we g...w -- in which all the vesicles are released at the active zone -- that's taken for granted now." The function of shotgun neurotransmitter release is unknown,...

Nanowires can detect molecular signs of cancer, scientists find

...e inactive in most of the body's somatic cells but active in at least 80 percent of known human cancers. In testing of extracts from as few as 10 tumor cells, these receptors allowed real-time monitoring of telomerase binding and activity. Lieber says nanowire arrays could easily be scaled up to detect man...

Duke Experiments Boost Radiation's Cancer-Killing Effects

...the team could observe the effects while HIF-1 was active and when it was blocked. Drugs to block HIF-1 have been used in previous studies conducted at Duke and elsewhere, but such drugs inhibit other proteins as well, making it impossible to distinguish which effects are related to HIF-1 and which are not....

IBM Transforms the Art of Scientific Expeditions

...the team could observe the effects while HIF-1 was active and when it was blocked. Drugs to block HIF-1 have been used in previous studies conducted at Duke and elsewhere, but such drugs inhibit other proteins as well, making it impossible to distinguish which effects are related to HIF-1 and which are not....

Molecular miners find pain relief drugs from the sea

...e venom is a cocktail of thousands of biologically active compounds of which only a few hundred have been identified. Associate Professor Gayler says the team, by using genes as the starting point, are able to minimize the number of cone snails required to develop new tools and therapies for medical resear...

Can two killers make a cure?

... virus was very efficient: the gene it carried was active in 24 per cent of airway cells after two months, a...he lungs of monkeys. After two months the gene was active in 21 per cent of cells, Kobinger told New Scientist. He is preparing the results for publication. ...

Newfound roadblock to interferon effectiveness against malignant melanoma

...ey have found that when a gene called STAT5 is too active in melanoma cells, it can counteract the anti-cancer effect of interferon. Interferon normally impedes the growth of cancer cells, whereas STAT5 is thought to act to promote cellular growth. The new work, published by Professor Schartl and his colle...

Aloe vera coating may prolong freshness, safety of fruits and vegetables

... processing technique that maximized the amount of active compounds in the gel, Valero and associates say. The gel can also be applied as a spray, they add. The untreated grapes appeared to deteriorate rapidly within about 7 days, whereas the gel-coated grapes were well-preserved for up to 35 days under th...

Secret sex life of killer fungus?

...genes involved with detecting mating partners were active in the fungus. Taken as a whole, the study's results indicate that the fungus has a recent evolutionary history of sexual activity and might still be having sex, if thus far unseen by human eyes. These results are important because if the fungus doe...

Living with salt

...ures may enable the algal carbonic anhydrase to be active in the presence of salt, though not dependent on it. In a surprise twist, the researchers discovered that one other known carbonic anhydrase - found in mouse kidney - sported a similar, salt-tolerant construction. Pondering why a structure conferring...

Two designer drugs hit same lung cancer target, but only one is effective

...sion of the cancer by shutting down the abnormally active growth signal receptor, EGFR," says Janne. "If you want to choose a way of inhibiting the mutant EGFR receptor, you would pull Iressa and Tarceva off the shelf, not Erbitux." Iressa and Tarceva are known as small-molecule drugs that can be taken ora...

No small feat: First ever gene therapy success for muscular dystrophy achieved

...d legs; and they grew faster, were physically more active and lived four times as long as untreated animals. "While we have much farther to go until we can say gene therapy will work in children, we have shown here a glimmer of hope by presenting the first evidence of a successful gene therapy approach tha...

Gaining ground in the race against antibiotic resistance

... seven-fold. The mutations influenced the enzyme's active site, where the chopping of antibiotic molecules takes place. One of the mutations has already been found in nature, in a lactamase from Pseudomonas. In some cases, there is a tradeoff associated with antibiotic resistance: the bacteria's success in...

New technique could alter field of mouse genetics

...posons have been used in mice before. But one such active transposon, Sleeping Beauty, does not appear to travel widely among the chromosomes and cannot carry larger fragments of DNA. As a result, scientists have been searching for stable, versatile transposons that can insert randomly in many different mam...

Life's origins were easier than was thought

...ng it into proteins. These proteins have a direct active role in the chemical reactions of the cell. In the early stages of life, it seems that the first RNA chains would have had the dual role of self-replicating (as is today the case with DNA) and participating actively in the chemical reactions of the c...

Long-sought flower-inducing molecule found

...T" produces the "messenger molecule". This gene is active in leaves and its activity is controlled by the length of the day. When the gene is activated, a messenger molecule is produced that is transported to the shoot tips where it very efficiently induces the "gene programs" that control the formation of ...

New law for resolution allows unprecedented sharpness in fluorescence microscopy

...bstantially improve the analysis of pharmaceutical active ingredients and protein interactions in cells in future. Original work: [1]Hell, S. W. Strategy for far-field optical imaging and writing without diffraction limit. Phys. Lett. A 326(1-2): 140-145 (2004) [2] Westphal, V., and S. W. Hell Nanoscale ...

Water management in cells

...els to remove excess water and salt or osmotically active particles from the cell. Tomassen studied cells that are highly sensitive for osmotic disruption. He discovered that cells permeable for water can more easily respond to changes in salt concentrations and that volume changes are facilitated by the ...

Exercise aside, genes may ultimately dictate seniors' mobility

...everyone responds the same, even when they do lead active lives - for reasons that have not been entirely cl...ews is that regardless of genotype, the physically active people were at lower risk of losing mobility, suggesting that everyone should exercise to preserve m...

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