Of mice and men's (and women's) contraceptives
...ll inhibitory molecule, it can't be a protein also active in such somatic tissues as brain, heart, liver, and so forth, only in the reproductive cells we want to target." Investigating germ cell molecules for contraception is also desirable because it frequently allows reversibility. Hecht and colleagues h...Master gene controls healing of skin in fruit flies and mammals
...mal embryos. The group also showed that the genes active in the mutant flies' lesions were activated in normal flies in cells surrounding a wound created with a sterile needle. The researchers then worked backward, using bioinformatics--computational analysis of DNA sequences--to identify grainyhead as the...Two chemicals boost immune cells' ability to fight HIV without gene therapy
...and allows the immune cells to remain youthful and active as they replicate under HIV's attack. Drugs that activate telomerase also offer therapeutic potential for a wide spectrum of degenerative diseases and chronic conditions in which cellular aging plays a role. "I'm really excited by our findings. This...Prescription Drug Patches Gaining Ground, Tackling New Therapies
...that are capable of delivering sustained dosing of active compounds for several days in a smaller package. “The number of drug therapies being developed in patch form is expanding,?explains George Perros, Greystone Managing Director. “At the same time, improvements in patch esthetics and the success of exis...Gov't Creates Gene Database of Normal Human Tissues
...n. "Genes identified by the database as abnormally active in a particular disease could become potential tar...." Each organ revealed a very distinct profile of active genes, different from all others. However, the gene profiles from different organs that share simila...Remote control flies? Fly behavior controlled by laser light
...in moving neuroscience from passive observation…to active and predictive manipulation of behavior," the Cell authors write. Miesenböck also says "one could use this method to restore neural signals that have been lost" due to injury or disease, such as in spinal cord trauma, although he notes that the poss...Young Blood Revives Aging Muscles, Stanford Researchers Find
...e cells that help liver tissue regenerate are less active in older animals, but again the cells responded more robustly when the livers in older mice were bathed in the younger blood. Clearly, something in the youthful blood revived the regenerative cells in muscle and liver. "We need to consider the possi...Disabling gene defuses rheumatoid arthritis in mice
.... Scientists once thought the cells that were most active in these attacks were adaptive immune cells including T cells. Most of these cells are like guided missiles: they get a fix on a specific target, pursue it and attack it. "Classically, everyone thought that the T cells somehow recognized something s...Active Vaccine Prevents Mice From Developing Prion Disease
...hool of Medicine scientists have created the first active vaccine that can significantly delay and possibly ...because it breaks new ground in demonstrating that active immunization can protect a significant percentage of animals from developing symptoms of prion disea...Researchers Identify Cause of Early Bird Sleep Disorder
...led a kinase that is made by the gene - to be less active than normal. The lead author of the paper in Nature is Ying Xu, a member of the team in San Francisco. Other team members are at the University of Vermont and the University of Utah. ...Asymptomatic HIV babies could use earlier treatment
...with a combination of three drugs, known as highly active antiretroviral therapy, or HAART, was not available when the study began in 1988.) Current guidelines for treating HIV-infected infants leave the decision of when to begin treatment to the child’s physician—in part because the long-term effects of o...Second messenger NAADP shows fast, dose-related impact on satiety cycle
...d adenine dinucleotide phosphate (NAADP), which is active in cells from plants to humans. NAADP is thought to be a so-called "second messenger," because it works from inside cells, rather than externally. However its mode operation remains unknown ?and controversial in several aspects. Results of a new stu...Unlike other mammals, newborn dolphins and orcas stay active 24/7 during first months of development
...ue from other mammals, with calves of both species active 24 hours a day during their first month. The moth...a vital function in adults. The ability to remain active and responsive after birth has several apparent advantages for newborn cetaceans: Movement and wakef...Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines
...velopment (CMLD). Although drug development is an active field of research, there have been few ways to predict optimal drug design. The molecular targets of many drug candidates are unknown and are often difficult to tease out from among the thousands of gene products found in a typical organism. This “bl...Whole genome promoter mapping - Human Genome Project v2.0?
...binding to each gene's promoter to identify 10,567 active promoters, 6 091 of which were previously unknown. LICR's Dr. Bing Ren, the senior author of the study and a faculty member at the UCSD School of Medicine, says that although scientists have found most of the protein-coding genes in the human genome...Climatologists discover deep-sea secret
...ing that waters in the southern hemisphere play an active role in sudden climate changes. Today's climate in Europe and North America is greatly influenced by the gulf stream. This ocean current carries warm water from the Gulf of Mexico northwards along the Florida coast, eastwards across the Atlantic and...Major new UNC-based drinking water study suggests pregnancy fears may be overstated
...ould not have done this useful study without their active cooperation," Savitz said. A number of earlier investigations have suggested that long-term exposure to water purification byproducts might be related to bladder cancer, an issue not addressed in the present study. ...Survey reveals women and doctors aren't talking about HPV
...mon, affecting an estimated 80 percent of sexually active adults in their lifetime, in some cases staying dormant until years after the initial infection. Yet few are talking about the relationship between HPV and cervical cancer despite the fact that advanced screening is available, which can detect the vi...Hopkins AIDS experts issue warning about global efforts to provide drug therapies
... transmitted diseases. Eager to return soldiers to active duty, wartime needs outweighed civilian concerns, but this did not sway public opinion that the military was wasting its share of medication. "While the lack of a plan is the worst-case scenario, even a plan with no public input can backfire if it f...