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Tag: "activation" at biology news

Viral DNA sequence a possible trigger for breast cancer

...sually found in immune cells and helps trigger the activation and proliferation of the cells. These sequences have also been found in proteins from some other cancer-causing viruses such as Epstein Barr virus and Kaposi's sarcoma virus, but what role this sequence plays in cancer development has remained unexpl...

Man and mouse share genome structures

... for specific developmental programs. This global activation may have implications for understanding mechanisms behind certain cancers, Bernstein believes. For example, proteins that place methyl groups on histones can, when mutated, cause leukemia. Bernstein hopes to apply the new technology to characterize c...

Researchers discover way to make cells in the eye sensitive to light

...authors, comments: "It is quiteremarkable that the activation of a single gene can create a functionalphotoreceptor. It is an important proof of principle that melanopsincan make non-light sensitive cells receptive to light, and although nota cure, could have applications in treating some forms of blindness."Dr...

Bound for destruction: Ubiquitination protects against improper Notch signaling

...n,loosing it into the cytoplasm and triggering the activation oftranscription factors within the cell’s nucleus. In addition to itseffects on wing structure in flies, Notch signaling is known to beimportant in a number of neural cell fate determination anddevelopmental processes, and is conserved in species fro...

An HIV Protein Plays a Surprising Role in Gene Activation

...ncoded in the HIV genome, is required for HIV gene activation and viral replication. It affects these processes, the current model holds, by stimulating transcript elongation and increasing RNA polymerase's processing efficiency. In a new study, Tamal Raha, Grace Cheng, and Michael Green work with human cell li...

Enzyme shown to help protect genomic stability

...s. Enzymatic modifications to histones control DNA activation or silencing through the addition or removal of ac...n histones where ubiquitin is associated with gene activation and to maintain low levels of the ubiquitin molecule at those sites. Interestingly, Ubp10 appears t...

In the sea slug's defense against lobsters, confusion is key

...viors stimulated by the slug's secretions resemble activation of a feeding pathway, the researchers named this novel chemical defense "phagomimicry." The stickiness of the slug's secretions appears to contribute to long-lasting effects on the target despite the aqueous environment, enhancing the effectiveness o...

Researchers identify target for cancer drugs

...ion of cell division and survival. Abnormally high activation of Akt has long been implicated in a variety of ca...t on discovering an important missing piece of the activation process. This missing component, a molecule called mTOR, is a protein that influences a cell's abil...

Nanogen Issued Patent for Electronic Microarray With Memory

...s data management efficiency by tracking test site activation and array usage directly on the electronic microarray cartridge. "This addition to our growing intellectual property portfolio illustrates our ability to develop differentiated advanced diagnostic products that add value to the company and to resear...

Scientists identify genetic pathways essential to RNA interference

...ebsite at http://www.sciencexpress.org. "The gene activation produced by RNAi is exquisitely specific, which gives it enormous potential for therapeutic application," says Gary Ruvkun, PhD, of the MGH Department of Molecular Biology, the study's senior author. "Imagine short, double-stranded RNA molecules that...

New insight into people who 'see' colors in letters and numbers

...ging (fMRI) of their brains reveals that they show activation of color-perception areas. The researchers said t...earchers found that the synesthetes showed greater activation in a color-perception region of the cortex when viewing graphemes, compared to normal control subjec...

How an AIDS-Related Cancer Unleashes Inflammation

... machinery is able to synthesize, said Ganem. The activation of MK2 also increases production of blood-vessel-f...ngiogenic factors, including the protein VEGF. The activation of angiogenesis pathways by kaposin B fits with observations made in patients with KS, Ganem noted. ...

Effective Cancer Treatments Follow The Clock

...ffect might be due to differences in the metabolic activation of the anti-cancer drug, but found essentially none. “This was a real surprise, because some of the enzymes involved in activating CY in the liver show circadian rhythms,?said Takahashi. “We thought that the liver might be activating the drug more st...

Scientists identify molecule that regulates well-known tumor suppressor

...ased PKB/Akt activity, while increased DJ-1 led to activation of PKB/Akt and enhanced cell survival. In cancer cells from breast cancer patients, elevated PKB/Akt activity and reduced PTEN expression were associated with elevated DJ-1levels. DJ-1 levels were increased in cells from lung cancer patients, and DJ-...

Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive

...nts looked at a photo of his/her beloved, specific activation occurred in the right ventral tegmental area (VTA)...covery, Brown said, was that "to our surprise, the activation regions associated with intense romantic love were mostly on the right side of the brain, while the ...

Scientists identify genetic pathways essential to RNA interference

...ebsite at http://www.sciencexpress.org. "The gene activation produced by RNAi is exquisitely specific, which gives it enormous potential for therapeutic application," says Gary Ruvkun, PhD, of the MGH Department of Molecular Biology, the study's senior author. "Imagine short, double-stranded RNA molecules that...

Decoding the logic of olfaction

...mical structures showed highly similar patterns of activation in the cortex. "This finding gives a hint that there is some logic to the way that information is being mapped onto the cortex," said Buck. "We don't know what that logic is, but it seems as if it has something to do with the molecular features of th...

Genpathway and Baylor College of Medicine Identify New Genes in Breast Cancer

...mical structures showed highly similar patterns of activation in the cortex. "This finding gives a hint that there is some logic to the way that information is being mapped onto the cortex," said Buck. "We don't know what that logic is, but it seems as if it has something to do with the molecular features of th...

Mouse gene shows new mechanism behind cardiac infarction in man

...r a protein called OX40L, which is involved in the activation of immunological T cells. These cells, in turn, play an important role in the pathogenesis of atherosclerosis and of a number of chronic inflammatory diseases. The new finding will spur further research into the relationship between the protein and c...

Biochemists report discovery of structure of major piece of telomerase; implications for cancer

...itely. Although it is not known whether telomerase activation is just a marker for cancer cells or involved in causing it, telomerase is an attractive target for development of anti-cancer drugs by pharmaceutical companies. The research, which was federally funded by the National Science Foundation and the Nat...

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