Decoding the logic of olfaction
... receive input from a single type of receptor were activated by concentrations of odorants normally found in the environment. "One intriguing possible explanation for this discrepancy is that the cortical neurons might be acting as 'coincidence detectors,'" said Buck. "They might respond only when they get inp...Genpathway and Baylor College of Medicine Identify New Genes in Breast Cancer
... receive input from a single type of receptor were activated by concentrations of odorants normally found in the environment. "One intriguing possible explanation for this discrepancy is that the cortical neurons might be acting as 'coincidence detectors,'" said Buck. "They might respond only when they get inp...A little stress gives beneficial oomph! to immune system
...ut most remain dormant until an immune response is activated by wounding or infection or until the brain identifies a stressful situation. When that happens, the brain releases hormones that set troops of these immune cells into motion. The cells travel to potential battle stations ?primarily the skin along wi...Protein prevents detrimental immune effects of bacterial sepsis
...xpression of annexin 1 and found that the gene was activated as early as 1.5 and 6 hours after LPS administrati...e protective effects of the annexin 1 pathway were activated in the first few hours following toxin administration. In fact, when annexin 1 knockout mice were gi...Activation of thermoreceptors mediates raw garlic's burning pungency
...ng to a remarkable family of receptors that can be activated by temperature and chemicals. Some TRP channels, i...ngent component of chili peppers, whereas TRPA1 is activated by noxious cold and by pungent compounds found in cinnamon oil, mustard oil, and wintergreen oil. Th...Gladstone investigators discover how resting T cells avoid HIV infection
...here HIV fails to grow, and only the large form in activated CD4 T cells, where the virus efficiently grows and...rge form of A3G into the protective, small form in activated CD4 T-cells. In this case, the goal would be to identify small molecules that promote the disassembl...UCSD medical/bioengineering reseachers show titanium debris satobtage artificial joints
... of the protein RANKL by osteoblasts recruited and activated osteoclasts at the insertion sites, further weakening the bone. Larger titanium particles also activated metalloproteinases, which chop up the extracellular matrix that holds cells together. ### Currentl...Master gene controls healing of skin in fruit flies and mammals
...the genes active in the mutant flies' lesions were activated in normal flies in cells surrounding a wound creat...o heal. "The genes involved in cuticle repair are activated very quickly, within 30 minutes after injury," said Joseph Pearson, a graduate student working under...Science study holds implications for gene therapy and stem cell biology
...ia in mice, because several "signaling" genes were activated that worked in concert to cause disease. The ques...n left: What happens if only one of these genes is activated in a stem cell? This question is addressed in the newly published Science study. Researchers found ...Molecular thermometers on skin cells detect heat and camphor
...The most obvious evidence is that TRP channels are activated by thermal heat within a particular temperature ra...to the extremely hot. TRPV3, for instance, becomes activated at warm and hot temperatures of 33° C (91.5° F) and above. Similarly, other TRP channels are specifi...Structure-building cell signals also may influence learning and memory
...leagues found that when the ephrin subtype EphrinB activated its EphB receptor, a cascading chemical pathway wa...own that animals injected with addictive drugs had activated EphB receptors, and that there is a connection between synaptojanin-1 and bipolar disorders and schi...Newly Discovered 'Branding' Process Helps Immune System Cells Pick Their Fights
...s also knew that when antigen-presenting cells are activated by inflammatory factors or microbial products, they start putting out chemically unstable compounds such as nitric oxide and superoxide. Together, these compounds generate peroynitrate, a highly potent chemical that modifies many proteins. Unanue's ...Future diabetes drugs may target new protein interaction
...entists reported that a compound found in red wine activated yeast's sirtuin1-equivalent and extended the organism's lifespan. Moving up the food chain, decades of reports have shown that drinking moderate amounts of red wine is associated with a longer life for people. But at this point, knowing for sure whe......entists reported that a compound found in red wine activated yeast's sirtuin1-equivalent and extended the organism's lifespan. Moving up the food chain, decades of reports have shown that drinking moderate amounts of red wine is associated with a longer life for people. But at this point, knowing for sure whe...Computational verification of protein-protein interactions by orthologous co-expression
...entists reported that a compound found in red wine activated yeast's sirtuin1-equivalent and extended the organism's lifespan. Moving up the food chain, decades of reports have shown that drinking moderate amounts of red wine is associated with a longer life for people. But at this point, knowing for sure whe...Eliminate Data Analysis Bottlenecks in Drug Discovery
...entists reported that a compound found in red wine activated yeast's sirtuin1-equivalent and extended the organism's lifespan. Moving up the food chain, decades of reports have shown that drinking moderate amounts of red wine is associated with a longer life for people. But at this point, knowing for sure whe...Gov't Creates Gene Database of Normal Human Tissues
...s can be tested by manipulating them so that genes activated in the cell will match up with the known gene samples, like two pieces of Velcro attaching to each other. The cellular genes are treated with fluorescence and literally light up the gene dots on the chip. The light pattern is then measured with a spe...Remote control flies? Fly behavior controlled by laser light
...r minutes, depending on whether the neural circuit activated by the remote control has feedback loops that keep the circuit. "In the case of the flight circuits," he says, "it is like pushing a swing. One initial kick and it keeps swinging back and forth for a while." ### The study was supported by grants fr...Natural Killers Could Lead to New Hepatitis Treatments
...ough vessels with the blood flow and when they are activated coming to a stop and then crossing through vessel walls in response to a signal.?/p> The researchers observed that the roving NKT cells stopped their movement when alerted by a foreign protein, called an antigen, “We think this is a reflection of...Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show It's Snot
...am found that in chronic sinus infection patients, activated white blood cells (eosinophils) cluster in the nasal and sinus mucus and scatter a toxic protein (major basic protein) onto the nasal and sinus membrane. While major basic protein was not distributed in the nasal and sinus tissue, the level of this p...