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Tag: "activated" at biology news

Man and mouse share genome structures

...the genome, we see short stretches associated with activated histones," Bernstein said. "However, in the HOX regions, we see huge stretches of genome, many thousands of base pairs in length, that are completely covered by tags." The researchers speculate that these unique chromatin structures could be activati...

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

... saturated fats. The researchers report that when activated by harmful fats, PGC-1beta alters liver metabolism through a cascade of biochemical signals. The result is an upsurge in the liver's production of very low-density lipoprotein (VLDL) cholesterol, the precursor of low-density lipoprotein (LDL) cholest...

Plants, animals share molecular growth mechanisms

...arned that a large protein complex, known as WAVE, activated ARP2/3, but they didn't know specifically which WAVE protein was the actual switch. Their latest research showed that a WAVE protein they've dubbed DISTORTED3 (DIS3) turns on APR 2/3, which in turn triggers formation of new, growing actin filaments. ...

Bound for destruction: Ubiquitination protects against improper Notch signaling

...ent mechanism in cell fatedetermination. Notch is activated bya protease that is present ubiquitously in the c... question of how Notchreceptors that have not been activated by a ligand are protected fromdigestion by that protease. Now, in a report published in the December...

U of M researcher examines newly emerging deadly disease

...ients should also be given early administration of activated protein C (i.e., drotrecogin) in an attempt to minimize purpuric skin injury and to slow the inflammatory cascade before irreparable tissue injury occurs. In addition, because toxic shock syndrome is mediated by superantigens, it is possible that int...

Jefferson Virologists Coax HIV Out of Hiding

...t the virus wasstimulated to higher levels and was activated in more patients thanwith other compounds. Dr. Pomerantz’s group also discovered that IL-7appears to stimulate a group of sub-strains of HIV that are differentthan those brought out of latency by other agents, such as IL-2,another immune cytokine, or...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

...0 percent of cancers where it is over-expressed or activated by mutation. According to Slack, a member of the Yale Cancer Center, it is one of the most identifiable causes in some forms of lung cancer. His team has identified let-7, a natural and separately transcribed RNA that maps to a chromosomal region ass...

Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease

...ising exception in the way some critical genes are activated by the protein packaging. These proteins act like ...ntrol how we develop in the womb. Instead of being activated individually like most genes, the HOX genes appear to be turned on in groups by massive numbers of t...

U-M scientists find genes that control growth of common skin cancer

...followed by theemergence of malignancies that have activated alternativecancer-causing pathways. According to Hutchin, the fact that this doesnot happen in regressed mouse BCCs suggests that any residual human BCCcells, if present, should also remain in check as long as the Hhpathway is effectively inhibited.F...

Researchers trace evolution to relatively simple genetic changes

...ow the Eda gene is used; how, when and where it is activated during embryonic growth. Also, to be sure they're working with the correct gene, the research team used genetic engineering techniques to insert the armor-controlling gene into fish "that are normally missing their armor plates. And that puts the pl...

Octopuses occasionally stroll around on two arms, UC Berkeley biologists report

...ow the Eda gene is used; how, when and where it is activated during embryonic growth. Also, to be sure they're working with the correct gene, the research team used genetic engineering techniques to insert the armor-controlling gene into fish "that are normally missing their armor plates. And that puts the pl...

Beyond lithium for bipolar disorder

...so the researchers set out to find genes that were activated by this inhibition. They treated slices of rat bra...ne chips"--to detect genes that were unequivocally activated when inositol was depleted in the brain slices. They discovered several genes that they concluded "...

How an AIDS-Related Cancer Unleashes Inflammation

...nts, they discovered that the binding of kaposin B activated MK2, leading to higher levels of cytokines in the cell. Activated MK2 does this by prolonging the stability of cytokine messenger RNA ?the genetic blueprint for cytokine proteins. The longer these messenger RNAs remain in the cell, the more cytokine ...

Asthma gene clusters identified

...sters of known genes have been identified as being activated in acute forms of childhood asthma. Dr. Hershey said the findings open the door to the possibility of developing treatments based on the unique genetic profile of patients. For example, specific therapies for acute asthma could be targeted to genes ...

Controlling protein diversity

...mone binds to receptors inside the cells, they are activated to seek out target genes. They then recruit the coactivators ?in this case CAPERá and CAPERâ. These coactivators not only cause the gene to begin the process that results in protein production, they also determine what kind of RNA (a kind of genetic ...

Multi-purpose protein regulates new protein synthesis and immune cell development

...e discovered that the unfolded protein response is activated in many diseases from viral infections to stroke to Alzheimer's disease," says Kezhong Zhang, Ph.D., a senior research associate in biological chemistry and first author of the paper. "All these things disrupt protein folding and put stress on the ce...

Computational Method Speeds Mapping of Cell Signaling Networks

...ting it for a quick response. These signals prompt activated T-cells to multiply rapidly and send out molecular "distress signals" that attract other immune system molecules to battle the infection. Components in the pathway are chemically altered during the signaling. Such alterations occur only at points of...

Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive

...with the emotions or sex drive. Brain systems were activated that humans share with other mammals. So the resea..." He said, "Our findings show that the brain areas activated when someone looks at a photo of their beloved only partially overlap with the brain regions associa...

Used in a new way, RNA interference permanently silences key breast cancer gene

...er development. The technique permanently silences activated STAT3, a crucial gene found in some human breast t...breast cancer. When hijacked by a cancer cell, the activated gene is believed to interfere with the ability of key immune cells to attack a growing tumor. Inves...

New understanding of DNA repair may pave way to cancer treatments

...tein ATF2 ("Activating Transcription Factor-2") is activated by a protein kinase called ATM ("Ataxia-Telangiectasia Mutated), which stimulates DNA repair. ATF2's role in regulating expression of proteins that control cell cycle and programmed cell death is well established. The current study is the first to de...

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