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UAB scientists discover the origin of a mysterious physical force

...ten proteins designed to prevent or strengthen the action of other substances. In these cases, accurately identifying the protein folding is essential, since the form these proteins take on when they fold influences how effectively they are able to act. Fully understanding the properties of this force that...

Drug That 'Tags' Decision-making Areas Of The Brain May Aid

...kherjee said.Scientists have known that nicotine’s action on these receptors elicitsdopamine in various brain regions implicated in nicotine addiction andother disorders. Nicotine acts by opening specific membrane proteins,called nicotinic receptors, and changing the electrical properties ofthe cell. The hu...

Sea skate experiment sheds light on human cell transport

...arned how cellular channels, or gates, spring into action when skate red blood cells become engorged with water. Vesicles, or tiny fluid-filled sacs, carry these gates up to the cell membrane. The vesicles are inserted into the membrane and a chemical process known as phosphorylation takes place. This activ...

Spider Venom Could Yield Eco-Friendly Insecticides

... of insects to understand the toxins' mechanism of action at the cellular level. Because these toxins do not... is to create chemical insecticides that mimic the action of spider toxins. Many insects have developed immunity to DDT and other chemical controls because mo...

Gene variations explain drug dose required to control seizures

...vidence linking variation in genes involved in the action or metabolism of the anti-epileptic drugs, carbamazepine and phenytoin, to the drugs' clinical use. The study is the first to emerge from a partnership, aimed at tailoring the treatment of epilepsy to patients' genetic makeup, between the Department ...

Alcohol's effects on gene expression in the central nervous system

... biological pathways are associated with alcohol's action in specific brain regions and certain mouse strains. "We were able to use gene expression profiling to determine that alcohol produces multiple effects on different biological processes," said McBride, "and that these changes are different in severa...

Nano-Probes Allow an Inside Look at Cell Nuclei

...dered if they could get even closer to the genetic action by transporting quantum dots inside cell nuclei. "We took the tool Paul developed and applied it to a problem faced by biologists every day ?getting inside the nucleus, a desirable target because the cell's genetic information resides there," says C...

Agilent Technologies releases automated literature search tool for biology researchers

...een shots of Agilent Literature Search Software in action are available at www.labs.agilent.com/research/mtl/projects/sysbio/sysinformatics/litsearch_screens.html. About Cytoscape Cytoscape is a bioinformatics software platform for visualizing molecular interaction networks and integrating these interacti...

Implanted Devices Detect High-Risk Heart Failure Patients

...ct to external stimuli by regulating their beating action -- are known to be at higher risk of suffering a heart attack. The new insight from CRT-D devices is possible because they record detailed data on heart function 24 hours a day. These new findings are important for two reasons, the researchers said....

Chemists identify immune system mechanism for methamphetamine binges

...revent some of the drug from reaching its place of action in the brain's pleasure center, users might requir...thamphetamine), might share a similar mechanism of action involving immune system recognition and a consequent rise in tolerance to the drug, Janda and his as...

Advances in the characterisation of the oyster mushroom genes

...ing down by live organisms takes place through the action of three types of enzymes: endogluconases, cellobiohydrolases y b-glucosidases. All these, necessary for the complete breaking down of cellulose, function by hydrolysing the glycoside links, but they vary in the specificity of substrate: the endoglu...

New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal

... that unless problems are detected early and swift action taken to find substitute drugs, previously treatable diseases could again emerge in more virulent forms. Public health officials cite antibiotic resistance as a growing problem for a host of diseases, from childhood ear infections to malaria. Last y...

Discovery may lead to better Candidiasis drug

...lows the cell to regulate its volume. The binding action of histatin acts like a "foot in the door," said Edgerton, UB research associate professor of oral biology in the UB School of Dental Medicine and senior author on the study. "Blocking the channel open allows a lethal unregulated flow of potassium an...

Leprosy microbes lead scientists to immune discovery

...for the two roles. The innate response swings into action when invading microbes are detected by molecules called Toll-like receptors (TLRs) that stick out of the cell's outer membrane, serving as a trip-wire to raise the alarm. The TLRs spur the monocytes to differentiate into the two rapid response cell t...

Used in a new way, RNA interference permanently silences key breast cancer gene

... targets a gene's product, its messenger RNA. This action then blocks translation and production of the protein that the gene encodes. In this study, the researchers used a lentivirus (a type of retrovirus) to deliver a specifically designed long-acting small interfering RNA (termed a short hairpin RNA, sh...

Scientists journey to southern Africa to unravel the secret world of elephant communication

...ter and freeze in unison, as if posing for a group action shot. O'Connell-Rodwell is particularly intrigued by one bull known as Billy Idol, easily recognizable by the extra holes in his large ears. "He's got a lot of ear piercings, hence his name," she explains. Unlike the other males, whose trunks are fro...

First technology to remove prions that cause vCJD from blood launched

...g vCJD and acting as blood donors. The most direct action to reduce the risk of transmission may come from new methods to provide prion protection." Prion Protection The Leukotrap Affinity Prion Reduction Filter removes all types of prions in addition to leukocytes (white blood cells) from red blood cells....

Grasping metaphors: UC San Diego research ties brain area to figures of speech

... supramarginal gyrus, was abysmal at understanding action metaphors such as "grasping an idea" or "putting your finger on the main argument." ...

Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

... can be exerted in living cells through microRNA's action in conjunction with several different proteins. "Most microRNA probably need the help of these other proteins and other molecules to target mRNA," says Han. "[This targeting] not only depends on their complementary sequence but on whether these prot...

Gladstone investigators discover how resting T cells avoid HIV infection

...4 T cells actively repel HIV infection through the action of the small, enzymatically active form of A3G, wh...n. When they detect its presence, they spring into action -- growing and dividing, releasing cytokines (proteins that the immune system uses to communicate be...

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