Technique offers new view of dynamic biological landscape
... a strategy would help to prevent these genes from acting together to compensate for an attack on just one p... that, we could identify groups of genes that were acting in a coherent way, to produce protein complexes. And then on a more global level, we could see how t...Researchers develop new method to help find deadly malaria parasite's Achilles heel
...argets for fighting malaria," said John Whitmarsh, acting director of the Center for Bioinformatics and Computational Biology at the National Institute of General Medical Sciences, which partially funded the work. "Ideker and his team have demonstrated the effectiveness of a computational approach based on ...Environmental tobacco smoke linked to behavior problems in children and pre-teens
...ationship between cotinine levels and increases in acting out; increases in holding things in, often manifested by anxiety and depression; increases in behavior problems as rated by parents, and behavior and school problems as rated by teachers; and, decreases in the ability to adapt to behavior problems. ...Rice bioengineers pioneer techniques for knee repair
... as scaffolds, foster the tissue growth process by acting as a template for new growth, but they always present a risk of toxicity due to the fact that they are made of materials that aren't naturally found in the body. In the newly reported findings, Athanasiou and postdoctoral researcher Jerry Hu, using ...Marine mammals are on the frontline of failing ocean health
..., such as nutrient overloading and global warming, acting together. These blooms are on the rise, and many are associated with toxins and bacteria that are harmful to humans. "We need to figure out what is causing this increase," says Bossart. "It's in our own best interest." Mammals Are What They Eat ...Sea coral's trick helps scientists tag proteins
...uorescent tail is produced along with the protein, acting like a beacon to researchers who want to learn what the main protein does and where it goes. To test how well the new tag labeled and tracked target proteins, the team fused Dendra to proteins that form the cytoskeleton of the cell, including actin ...Brain differences could explain why males and females experience pain relief differently
...ion of pain. Both narcotics and analgesics work by acting on these brain regions. Interestingly, while thousands of studies have been conducted examining the role of the PAG and the RVM in pain and analgesia, these studies were conducted exclusively in males. The study by Murphy is the very first to examin...MiRNA fingerprint identified in platelet formation
...ury. They also say some of these same miRNAs, when acting abnormally, may contribute to certain forms of leukemia. "Basically, we found that a specific set of miRNA genes are turned off in normal platelet development, but turned on in certain platelet-related leukemia cells," says lead author Dr. Ramiro Ga...Deep-rooted plants have much greater impact on climate than experts thought
...n by chemical potential gradients, with tree roots acting like pipes to allow water to shift around much faster than it could otherwise percolate through the soil. In many plants that exhibit hydraulic redistribution, the tap roots are like the part of an iceberg below water. In some cases these roots can r...New brain hormone puts brakes on reproduction
...and factors produced along the "reproductive axis" acting via feedback loops to keep the body's hormones within the optimal range for fertility and successful mating. The head of the axis is the brain's GnRH-producing hypothalamus, which communicates via a blood portal with the anterior pituitary and stimul...U of MN researchers develop way to visualize synchronized interactions of nerve cells in the brain
... assess the dynamic interactions of brain networks acting in synchrony, as reported in a recent issue of the Proceedings of the National Academy of Sciences. "This discovery will allow researchers to better evaluate the brain function of people with various diseases, such as Alzheimer's disease, and to ...Research could lead to better drugs and whiter whites
...works could one day lead to more effective, faster acting agents." ...Scientists identify molecular structure of key viral protein
...ion of the cell -- and it does this by essentially acting as a harpoon that shoots into the cell's membrane to bring about the fusion," said Jardetzky. "The metastable protein is a one-time-use machine," said Lamb. "It does its work and then it's finished, spent. And you want the protein to be triggered at...Loosen leash on cancer protein 'watchdog,' researchers say
...alled Mdm2, keeps p53 inactive until it is needed, acting like a leash on a watchdog. "p53 seems to be an important stress response gene that fights cancer when it works," Mendrysa said. "So we decided to see what we could do to increase p53's activity without completely cutting its Mdm2 leash." The scien...... livers. "Snakes produce a more stable and faster acting form of Factor X in their venom which is the only source of Factor X other than mammalian livers," he said. "They have developed the ability to deliver massive fatal doses of Factor X to specifically target the systems ofmammals." Dr St Pierre stud...VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum
...y our objective is to design and develop complexes acting by new mechanisms of action," said Nicholas Farrell, Ph.D., professor and chair in the Department of Chemistry at VCU, and lead author of the study. "Resistance to current drugs is due to poor cellular absorption and an increased ability of the cell ...Convergent evolution of molecules in electric fish
...an health, adds Zakon. "When natural selection is acting to cause changes in a part of a molecule, you know it's functionally important," he says. "Natural selection can start showing you the important parts of molecules. We took the evolutionary approach, which is very compatible with the clinical approac...Plants used to detect gas leaks, from outer space!
...initely in underground reservoirs then it can't be acting to absorb heat in the earth's atmosphere. "Our own research attempts to address some of the issues related to public acceptability and safety: Will there be leaks? What environmental effects will any leaks have? Can we detect leaks?" says Steven. ...Hepatitis C therapy: Inhibiting newly discovered microDNA molecule
...ession for as much as a third of the human genome, acting as key regulators of processes as diverse as early development, cell proliferation and cell death, and cell differentiation. Some miRNAs are located throughout the body, while others are found only in specific tissue. The miRNA whose surprising new ...Anti-inflammatory drug's potentially deadly side effect found to be rare
...in Queen's Square, London; and Eugene Major, M.D., acting director of research at the National Institute of Neurological Disorders and Stroke. It could convene meetings with or without a representative from the drug's makers.With Biogen and Elan Pharmaceuticals' assistance, researchers were able to conduc...