Prostate cancer uses Wnt signaling proteins to promote growth of bone tumors
...ls of DKK-1." "Our results suggest that DKK-1 may act like a switch on prostate cancer cell activity," Keller says. "When we altered the cells to increase the amount of active DKK-1, it blocked Wnt's signal, changing prostate cancer cells from an osteoblastic to a highly osteolytic cell line." To test ...Plant gene related to cancer treatment may foster new oncology drugs
..., called ATP-binding cassette (ABC) proteins, that act as delivery trucks to detoxify cells, send messages from cell to cell to influence biochemical reactions, and to regulate those reactions. The ABC proteins are so named because they must bind with ATP, the main cell energy source, in order to fulfill...DNA self-assembly used to mass-produce patterned nanostructures
...an be used create biological structures that could act as tiny sensors. ...Researchers know what you were about to say; fMRI used to detect memory storage and retrieval
...inceton University have provided evidence that the act of recalling a memory is a bit like mental time travel. Their study, presented in the Dec. 23 edition of the journal Science, demonstrates that the same areas of the brain that are active during an event are activated when a person attempts to recal...Role of microRNA identified in thyroid cancer
...ys de la Chapelle. Some scientists believe miRNAs act like oncogenes, molecules that promote cell growth, and they also feel they may be tumor and tissue specific. For example, in many other forms of cancer, miRNA activity is suppressed, but in PTC, researchers found just the opposite: 17 of the 23 mi...Genetic defenders protect crops from fungal disease
...m to share a common purpose. However, they seem to act via different mechanisms, and PEN2 protects against a wider range of fungal pathogens. For example, Arabidopsis plants with a disabled PEN2 gene are also more susceptible to Phytopthora infestans, the fungus responsible for the notorious Irish Potato...Key brain regulatory gene shows evolution in humans
... said their finding demonstrates how evolution can act more efficiently to alter the regulatory segments, or "promoters," that determine genes' activity, rather than on the gene segment that determines the structure of the protein it produces. Such regulatory alteration, they said, can more readily gener...Novel enzyme offers new look at gene regulation
...domain. This suggests that many other proteins may act similarly to methyl groups from histones or other proteins. The implications of the new findings are as diverse as the proteins that contain a JmjC domain. For example, hair loss occurs in individuals with mutations in the JmjC domain of a protein c...'Sharp' older brains are not the same as younger brains
... nerve cells, where chemicals released by one cell act upon another.) Synaptic communication is the way brains register and preserve information to form memories. The team found that while the older rats with compromised cognition had brains that had lost the ability to adjust the force of those synap...Genetic analysis of Asian elephants in India reveals some surprises
...ough the Western Ghat mountain range, was found to act a biogeographical barrier between the two in that case. "It is interesting that the Brahmaputra seems to have been a biogeographical barrier for several species," the authors write in their most recent study. "Population genetic studies of other sp...Recreating 'Flowers for Algernon' with a happy ending
...ation and undermines the learning process. "The act of learning creates physical changes in the brain,...sults in learning deficits," said Silva. "Statins act on the root of the problem and reverse these deficits. This enables the process of learning to phys...Researchers make long DNA 'wires' for future medical and electronic devices
...ise patterns. Ultimately, these DNA strands could act as wires in biologically based electronics and medical devices, said L. James Lee, professor of chemical and biomolecular engineering at Ohio State University. In the early online edition of the Proceedings of the National Academy of Sciences, Lee a...New study pinpoints epicenters of Earth's imminent extinctions
...he species that will be tomorrow's dodos unless we act quickly," said Taylor Ricketts, lead author of the study. "The good news is we still have time to protect them." Among the 794 imperiled mammals, birds, amphibians, reptiles, and conifers are monkey-faced bats, cloud rats, golden moles, poison frogs...Pretreating rogue cancer cells with aspirin cripples their resistance to targeted therapy
...he species that will be tomorrow's dodos unless we act quickly," said Taylor Ricketts, lead author of the study. "The good news is we still have time to protect them." Among the 794 imperiled mammals, birds, amphibians, reptiles, and conifers are monkey-faced bats, cloud rats, golden moles, poison frogs...ASU researchers 'wire' DNA to identify mutations
...ental conditions, DNA has been previously shown to act as both a conductor and insulator. "We have developed a technology that allows us to wire single molecules into an electrical circuit," said Tao, professor of electrical engineering in the Ira A. Fulton School of Engineering and also a researcher i...Superconducting magnet attracts molecular research
...ing field, causing them to essentially line up and act in unison, like a battalion of marching soldiers, said Pochapsky. The electrons, neutrons and protons within the atom have an intrinsic property known as "spin" and within the electromagnetic field created by the magnet, the frequency of the spinni...Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates
...cer nanotechnology, aptamers have the potential to act as targeting molecules - directing the delivery of nanoparticles to tumour-antigens, present on the surface of cancer cells. In general terms, therapeutic nanoparticles (~50 ?~250 nanometer) are specially designed delivery vehicles that can encapsula...Researchers use 'trickery' to create immune response against melanoma
...cer nanotechnology, aptamers have the potential to act as targeting molecules - directing the delivery of nanoparticles to tumour-antigens, present on the surface of cancer cells. In general terms, therapeutic nanoparticles (~50 ?~250 nanometer) are specially designed delivery vehicles that can encapsula...New maps reveal true extent of human footprint on Earth
... 2005) of the American Geophysical Union. "In the act of making these maps we are asking: where is the human footprint on the Earth?" says Amato Evan, a SAGE researcher who merged available census and satellite data to create visuals reflecting the reach of pasture and croplands worldwide. Chad Monfreda...Scientists directly view immune cells interacting to avert autoimmunity
... 1 diabetes, and to further develop therapies that act at the level of T cell interactions. The research, published online this week in Nature Immunology, includes online videos of these immune cell interactions ?the first time this has been accomplished. The scientists used fluorescent dye to mark dif...