A gene's first 'kiss' sets off that affair known as puberty
... Dr. Plant said. "However, it's unlikely that they act alone. Other signaling systems, some of which have probably yet to be identified in humans, help control GnRH release in primates." Besides learning that GPR54 and KiSS-1 are expressed inside the hypothalamus of primates at the time of puberty, the ...Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
...ology tounderstand how and where specific proteins act on a pollen tube is onemore step towards a better understanding of the fundamental processesinvolved, namely the network of the signaling process in plantreproduction,?said Ozkan. "A better understanding of the interactionof SCA with pollen tubes cou...New, automated tool successfully classifies and relates proteins in unprecedented way
...roundfeatures. Like fingerprints, a protein's SLFs act as a unique set ofidentifiers. Using a set of established SLFs, Murphy then developed acomputational strategy for automatically clustering, or grouping,proteins based on SLF similarities and differences. For his study,Murphy used images of randomly c...Scientists Replicate Hepatitis C Virus in Laboratory
...generate the correct ends of the HCV genome and to act as start and stop buttons to gene activity. The construct was “naked,?meaning that it contained only nucleic acids, the genetic material of the virus, and did not have the HCV viral envelope, a protective shell of lipids and proteins that surrounds t...Male circumcision reduces risk of HIV transmission from women to men
...udy to examine the probability ofHIV infection per act of heterosexual sex among a population withmultipl...robably of becoming HIV-infectedfollowing a single act of intercourse was calculated to be .0063, orone in 160. Uncircumcised men had a more than two-fold ...Computers to be used to find blueprint for new influenza drug
...e chemically similar to the sialic acid, but would act to inhibit the sialidase. This would hinder the virus from entering the cells, and from leaving them should they gain entry, thereby controlling the spread of the infection. Because of similarities between the enzymes used by different viruses and b...New Technique for Tracking Gene Regulators
...index the code, to find the placeswhere regulators act ?where the on/off switches are that determinewhich genes are at work in different types of cells under differentconditions,?he said.Previous, individual experiments have identified about 100 places whereCREB binds to DNA and regulates genes in humans...HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs
...need to be aware of this new risk we've found, and act accordingly. Worldwide, tens of thousands of people are taking protease inhibitors, and the numbers who experience these unexpected side effects are very low -- much less than 1 percent." Co-investigator Michael Ackerman, M.D., Ph.D. agrees that the...Learning to fight an adversary that won't stay down
...that are new, and some of them are very potent and act against most resistant strains," he says. "But the clinicians rightly try to keep these things in reserve for when they are really needed." ......vels of pollutants in different ocean. “The oceans act as a conveyer belt carrying contaminants across the globe and depositing them in the fats of seafood,?says Payne. Now in the final year of a five-year global voyage, Payne’s institute has found and collected skin samples from over 1100 sperm whales f...Clam embryo study shows pollutant mixture adversely affects nerve cell development
...loroethylene--a chemical cocktailknown as BCE--can act synergistically to alter a key regulator in nervecell development. While scientists have previously studied the effectsof these pollutants individually, this is the first time anyone hasdemonstrated that BCE's components can work together to adversel...Study identifies predictors of HIV drug resistance in patients beginning triple therapy
...loroethylene--a chemical cocktailknown as BCE--can act synergistically to alter a key regulator in nervecell development. While scientists have previously studied the effectsof these pollutants individually, this is the first time anyone hasdemonstrated that BCE's components can work together to adversel...Spider Venom Could Yield Eco-Friendly Insecticides
...ols because most insecticides are neurotoxins that act against only a small number of nervous system targ...ies within a genus. The toxin-enhanced virus would act like a magic insecticide bullet, targeting only cotton bollworms, for example, and leaving bees and ...Gene variations explain drug dose required to control seizures
...rchers, noting that many other anti-epilepsy drugs act on related brain proteins. "The range of doses ta... most drugs we know a lot about how and where they act in the body," Goldstein said. "The current results support the idea that known drug targets, transpo...Purdue proves concept of using nano-materials for drug discovery
...sist anti-tumor chemotherapy drugs. These proteins act as tiny pumps that quickly remove chemotherapy drugs from tumor cells, making the treatment less effective. Cancer cells exposed to chemotherapy drugs produce a disproportionately large number of the pumps, causing the cells to become progressively m...Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
...activated by the protein packaging. These proteins act like spools for the long strings of DNA that contain our genes and form chromosomes. The researchers studied chemical tags that are attached to the spools and switch on the genes they wrap. In most cases, they found these tags turn genes on and off i...ASU researchers finds novel chemistry at work to provide parrot's vibrant red colors
...on the parrot pigments that suggests that they can act as anti-oxidants to quench free radicals and potentially protect cells and tissues in the body from oxidative damage. Now, McGraw says, he's interested in learning more about the connection between the red colors and anti-oxidants within and among p...Transport System Smuggles Medicines Into Brain
...on the parrot pigments that suggests that they can act as anti-oxidants to quench free radicals and potentially protect cells and tissues in the body from oxidative damage. Now, McGraw says, he's interested in learning more about the connection between the red colors and anti-oxidants within and among p...Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation
...e likely it is that the patient's thymus gland can act as an efficient factory where stem cells become T cells. The thymus is an immune system organ behind the breastbone that processes immature "precursor" immune cells into specialized T cells. T lymphocytes are specialized immune cells carrying protei...... cell resistant to chemotherapy," said Chen. "They act like soccer goalies and punt therapeutic drugs out of the cancer cell. This prevents the drug from taking effect and allows the tumor to continue growing unchecked." In order to track the carrier's journey, the scientists added luciferase ?the prote...