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Tag: "abnormal" at biology news

Genetic testing still smart choice, despite uncertainties

...than 3 percent of healthy embryos are discarded as abnormal and only 1.5 percent are implanted with undetected...l embryo, if we choose (the one) normal cell in an abnormal embryo, we may think that embryo is normal and transfer it. "This occurs about 1 percent of the ti...

New view of cancer: 'Epigenetic' changes come before mutations

...enitor cells within an organ or tissue, altered by abnormal regulation of tumor-progenitor genes. This leads to a population of cells ready to cause new growth. The second step involves an initiating mutation within the population of epigenetically disrupted progenitor cells at the earliest stages of new cel...

Sickle cell disease corrected in human models using stem cell-based gene therapy

...ence technology. To prevent the production of the abnormal hemoglobin that causes sickle cell disease, a vira...all interfering RNA precursor designed to suppress abnormal hemoglobin formation. Tested in adult stem cells from SCD patients, researchers found that the newl...

Prostate cancer uses Wnt signaling proteins to promote growth of bone tumors

... first time Wnts have been shown to be involved in abnormal bone production in adult animals with prostate cancer." Hall is first author of a paper to be published in the Sept. 1 issue of Cancer Research, which presents results from U-M studies of Wnt proteins in human prostate cancer cell lines and in labo...

Building a better mouse model of lung cancer: FHIT counts

...au disease, an inherited disorder characterized by abnormal blood vessel growth in the eyes, brain, spinal cord, adrenal gland and other parts of the body. The scientists exposed mice deficient in both genes to a second carcinogen, DMN, which is also found in smoke but also in beer, fish meal and some preser...

Past illegal blood donation in China linked to hepatitis C virus infection

...us, concern about health effects of blood drawing, abnormal liver function tests or hepatitis, and shut-down of the illegal blood center. The investigators concluded that unhygienic plasma donation and receipt of blood transfusion are strong risk factors for HCV infection in rural central China, and that imp...

Newly recognized gene mutation may reduce seeds, resurrect plants

...in amount of wax overlaying leaves and stems. The abnormal plant, a mutant of RST1, had short, rounded leaves that turned purple during development, and then before flowering, the plant quickly browned and looked dead. It also had a large proportion of small, wrinkled, non-viable seeds with aborted embryos. ...

Neurotransmitters signal aggressive cancer, offer potential for early diagnosis

...bout what type of metabolism was going on in these abnormal cells compared to their normal non-cancerous count...This set of techniques demonstrated the linkage of abnormal GABA production to aggressive tumors. "We are able to examine not just genes, not just proteins, bu...

Yale scientists identify structure for RNA quality control

...However, little was known about what cells do with abnormal or misfolded RNAs that are not translated into pro...on between binding of normal RNA and "disposal" of abnormal and misfolded RNAs by Ro protein. Collaboration between the laboratories of Assistant Professor Kar...

Molecular trigger for Huntington's disease found

...ey regulatory molecule whose overactivation by the abnormal protein produced in Huntington's disease (HD) causes the central pathologies of the disease. The abnormal HD protein activates the regulatory protein called p53, which in turn switches on a host of other ge...

Variant prion protein causes infection but no symptoms

... Now, new research suggests that a variant form of abnormal prion protein--one lacking an "anchor" into the ce..., confirmed that they produced amyloid fibrils, an abnormal form of prion protein, and that they even had brain lesions. More remarkably, according to Dr. Chese...

Scientists uncover new clues about brain function in human behavior

... For several years, scientists have suspected that abnormal processing in the amygdala, an almond-shaped struc...al disturbances in a brain pathway associated with abnormal social behavior caused by a genetic disorder," said NIMH Director Thomas R. Insel, M.D. In this stu...

Two designer drugs hit same lung cancer target, but only one is effective

...he non-small-cell type, and colorectal cancer, the abnormal signals are generated by a normal EGFR molecule. In a small percentage of patients with non-small-cell lung cancer (NSCLC), the overactivity stems from a mutant EGFR protein: those patients tend to have a better outlook, and Iressa and Tarceva are pa...

Huntington's cure in flies lays groundwork for broader treatment approaches

...t can be attributed to dozens and even hundreds of abnormal gene functions. Yet in some cases, it might turn out that gene pathways stemming from different genes converge at some point, into one common "superhighway," says Yin. "If you know that, you can do something in the superhighway part," he says. Rese...

Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease

... exhibited a statistically significant decrease in abnormal metabolism, results considered similar to those ac... exhibited a statistically significant decrease in abnormal metabolism, while the untreated side showed a further increase in abnormal metabolism. The imaging ...

Malfunctioning bone marrow cells sabotage nerve cells in diabetes

...that have fused with bone marrow cells display the abnormal function and premature death found in neuropathy. Nerve cells that have not merged with the insulin-producing bone marrow cells remain intact and function normally. "Based on these findings, we speculate that a similar process contributes to some, i...

Reversal of role for a viral protein associated with the development of lymphoma

...sion of a functional protein or, worse, produce an abnormal protein that interferes with normal cell behavior. But just how a cell's molecular machinery eliminates long introns without making errors has puzzled scientists for years. Now, investigators at Carnegie Mellon University have discovered that a nov...

Carnegie Mellon University research reveals how cells process large genes

...sion of a functional protein or, worse, produce an abnormal protein that interferes with normal cell behavior. But just how a cell's molecular machinery eliminates long introns without making errors has puzzled scientists for years. Now, investigators at Carnegie Mellon University have discovered that a nov...

New lead reported in tumor angiogenesis

...ls induce new blood vessels to form and fuel their abnormal growth, a well-known process called angiogenesis. As published in this month's issue of the journal Cancer Cell, the scientists found that in addition to the well-known strategy of secreting proteins to trigger angiogenesis, tumor cells also physica...

Fruit fly studies open new window on cancer research

...ensitivity of a cell to a hormone that can trigger abnormal growth and cancer. Their discovery could lead to a completely new approach to tackling some cancers and the development of new drugs to stop uncontrolled growth in a wide variety of tumour cells. The researchers at the University of Oxford, funded i...

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