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Tag: "abnormal" at biology news

Alzheimer's study first to explain death of brain cells

...eviously discovered that Alzheimer's patients have abnormal amounts of heme in their brains. In new research results, Atamna's team showed that amyloid-beta readily binds with heme to form a compound that can be flushed from cells. When there is insufficient heme or too much amyloid-beta, however, the amyloid...

Single microRNA causes cancer in transgenic mouse

...ften act just like oncogenes, in that they promote abnormal cell growth that leads to cancer. Others, however,...or suppressors, because they block genes that keep abnormal cell division in check or induce prolonged survival. Our transgenic mouse model clearly shows that m...

MiRNA fingerprint identified in platelet formation

...nking certain patterns of miRNA to both normal and abnormal blood cell development, especially in diseases like chronic lymphocytic leukemia and lymphoma. Relatively little was known, however, about miRNA functionality in platelet formation. Platelets are created from stem cells in the bone marrow. They evol...

Absence of critical protein linked to infertility

...rrays to identify gene expression under normal and abnormal conditions during implantation. After messenger RNA profiling zeroed in on C/EBPb's activity, the researchers collaborated with Peter F. Johnson of the National Cancer Institute's Laboratory of Protein Dynamics and Signaling, who created mice that la...

Engineered mouse mimics cognitive aspects of schizophrenia

...archers have developed a mouse strain in which the abnormal activity of the dopamine machinery in a specific p...e receptor activity in the striatum contributed to abnormal prefrontal cortical function. Importantly, found the researchers, they could not reverse these cogn...

Attention shoppers: Researchers find neurons that encode the value of different goods

...such as eating disorders, compulsive gambling, and abnormal social behavior. Moreover, the OFC is part of brain circuitry implicated in drug abuse, which can also be thought of as a choice deficit. Padoa-Schioppa and Assad's results establish a more direct link between the activity of OFC and the mental valua...

U of MN researchers identify ataxia gene

...of Minnesota. Understanding the effects of this abnormal protein, which provides internal structure to cells, will clarify how nerve cells die and may provide insight into other diseases, including amyotrophic lateral sclerosis (Lou Gehrig's disease) and Duchenne muscular dystrophy.The research will be pub...

Fruit fly's beating heart helps identify human heart disease genes

...ed. "With this new model, we can rapidly correlate abnormal heart functioning with a specific gene mutation." ...

Master genetic switch found for chronic pain

...mals' response to "neuropathic pain." Such pain is abnormal pain that outlasts the injury and is associated with nerve and/or central nervous system changes. The animals rendered deficient in the gene, called Runx1, also showed lack of response to discomfort caused by heat and cold and inflammation. The resea...

Liver cancer linked to cellular repair pathway

...may lead to overactivation of Hedgehog and trigger abnormal cell growth, promoting cancer development. In test tube and cell culture experiments, blocking the Hedgehog pathway reduced growth of cancer cells by over 90 percent. Liver cancer, or hepatocellular carcinoma, often develops in people with cirrhotic...

New evidence questions the simple link between prion proteins and madcow disease

... scientists have struggled to make sense of how an abnormal variation of a normal protein can trigger an infec...he disease. When they injected material containing abnormal prion protein (PrP) into the sheep's gut, it was equally absorbed by all sheep. "This clearly shows...

Whole-genome study at Johns Hopkins reveals a new gene associated with abnormal heart rhythm

...entified a gene that may predispose some people to abnormal heart rhythms that lead to sudden cardiac death, a condition affecting more than 300 thousand Americans each year. The gene called NOS1AP, not previously flagged by or suspected from more traditional gene-hunting approaches, appears to influence si...

DNA gene vaccine protects against harmful protein of Alzheimer's disease

...n adjuvant, which increased the immune response to abnormal excessive levels, causing the dangerous brain inflammation. In addition, the immune response in humans may have involved antibodies called Th1, which were probably partly responsible for the inflammation. The gene injection in the mouse study produce...

Rare Tibetan antelope listed as endangered

...trial fibrillation, a disorder characterized by an abnormal heart rhythm. In order to demonstrate this possible use, the researchers produced real-time 3D images of a dog's right pulmonary veins -?sites that are targeted in treating atrial fibrillation. Similar 3D ultrasound devices also hold promise for mi...

3D ultrasound device poised to advance minimally invasive surgery

...trial fibrillation, a disorder characterized by an abnormal heart rhythm. In order to demonstrate this possible use, the researchers produced real-time 3D images of a dog's right pulmonary veins -?sites that are targeted in treating atrial fibrillation. Similar 3D ultrasound devices also hold promise for mi...

Scientists show how thinking can harm brain cells

...found that damage to the dendrites may not require abnormal glutamate exposure." The lab studies showed that elevated levels of PAF promoted beading on dendrites and injury to synapses following bursts of synaptic activity similar to those thought to be involved in learning and memory. "This mechanism does ...

How the neuron sprouts its branches

...isorders of brain development in children manifest abnormal dendritic structures," said Ehlers. "Also, it turns out that most neurodegenerative diseases, such as Parkinson's and Alzheimer's, are disorders of protein processing. But we know very little about how and where integral membrane proteins are synthes...

New technique helps researchers determine amino-acid charge

...have been linked to such problems as hypertension, abnormal insulin secretion, abnormal heart conditions and brain seizures. As a result, these membrane proteins are often targeted by drug...

Common viruses may cause cancer

...--arise in two principal ways: as a consequence of abnormal cell division, or as a result of cell fusion. By either mechanism, the resulting aneuploid cells no longer have the proper genetic makeup and frequently die. But researchers now know that tumor cells are often aneuploid--and very much alive. Whether ...

How Fruitflies Know It's Time for Lunch

...als express the gene hugin (hug), a gene linked to abnormal eating activity and expressed in only the subesoph...cher and Pankratz analyzed the DNA from flies with abnormal eating behavior. One group of these flies shared a mutant klumpfuss (klu) gene, normally responsible...

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