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Tag: "abnormal" at biology news

Common cancer gene sends death order to tiny killer

...rated that these tiny RNA molecules are frequently abnormal in cancer cells. "P53 is one of the most commonly mutated genes in human cancers," says Mendell. "And there is now a great deal of evidence that microRNAs themselves can act to either promote cancer or to stop cancer spread." To test their idea...

Researchers discover inherited mutation for leukemia

...ls use this process to silence unneeded genes. But abnormal DNA methylation can turn off genes that control cell growth, and that lead to tumor growth. "Our findings identify for the first time a gene that appears to be associated with hereditary CLL," says coauthor John C. Byrd, professor of internal med...

Cells re-energize to come back from the brink of death

The discovery of how some abnormal cells can avoid a biochemical program of self-dest... thrive. The finding offers an explanation of how abnormal cells that have cheated death once by disabling the main suicide pathway called apoptosis can also f...

Gene responsible for common hearing loss identified for first time

...th factor, and the disease manifests itself by the abnormal growth of bone in the middle ear, it may have a large potential for therapy”, she said. Improved understanding may also lead to prevention strategies. Ms Thys and her team decided to study a gene called TGBF1 which they already knew had non-geneti...

Clot-dissolving agent may be beneficial in treatment of severe frostbite

...ffected limb. From 2001 to 2006, six patients with abnormal blood flow on angiography received tPA within 24 h...kness tissue involvement, hemorrhagic blisters and abnormal perfusion on either angiogram or pyrophosphate scanning. Initiation of therapy within 24 hours of re...

Gene therapy study shows safety and statistically significant improvement in Parkinson's disease

...ements from baseline in both clinical symptoms and abnormal brain metabolism (as measured by positron emission tomography, or PET scanning). Although all patients had symptoms on both sides of the body, the procedure was performed on only one side of the brain, enabling the untreated side to serve as a study ...

Common treatment for methamphetamine overdose may damage brain cells

...we hope to examine if the loss of cells results in abnormal involuntary movements resembling Tourette's syndrome and Huntington's disease." ...

Vaccine prevents prion disease in mice

...nated with prions. The disease causes dementia and abnormal limb movements. Prion is a protein that is also an infectious agent. The proteins are so similar to proteins found normally that the immune system does not fight them off. To develop a vaccine that would stimulate the mice's immune system, resear...

Risk of lymphoma increases with hepatitis C virus infection

...e risk for cryoglobulinemia, a condition marked by abnormal levels of certain antibodies in the blood, was also elevated for those with HCV infections. The researchers looked at patient records collected from Veterans Affairs (VA) hospitals across the United States between 1996 and 2004. Researchers selecte...

Cornell lab confirms deadly fish virus spreading to new species

...hould avoid eating any fish (or game) that appears abnormal or behaves abnormally. Not all infected fish, however, exhibit symptoms. Some may be carriers, and visible signs of the disease may vary from species to species. Containing the spread of the virus in New York will require restrictions on the movem...

Proteasome activator enhances survival of Huntington's disease neuronal model cells

...PS function would improve catalytic degradation of abnormal proteins in HD. We first genetically engineered pr...ipate in the specific degradation of misfolded and abnormal proteins. ...

UCLA study uncovers clues for why Graves' disease attacks the eyes

...red that T-cells taken from GD patients contain an abnormal surplus of the receptor targeted by this antibody. An antibody must latch to a specific receptor ?like a key into a lock -- in order to elicit a cellular response. The receptors mobbed the patients?immune systems, even on T-cells that normally woul...

Heart failure: Intervention possibilities from imaging programmed cell loss

...he body's normal way of getting rid of unneeded or abnormal cells—may help in early identification of those individuals who are at risk of developing heart failure, say researchers in the April Journal of Nuclear Medicine. "Our study indicates that it is feasible to noninvasively identify cell loss—or apopto...

Gene found for rare disorder may reveal new pathway in mental retardation

...mechanisms in broader populations of patients with abnormal brain development, in mental retardation and possibly autism as well." ...

MIT model helps researchers 'see' brain development

...oks like. The next step is to see if we can detect abnormal development in diseases like autism by looking at folding differences,?said Fischl. This tool may also be used to shed light on other neurological diseases such as schizophrenia and Alzheimer's disease. ...

Loss of a universal tRNA feature reported

...e P enzyme that is no longer capable of catalyzing abnormal cleavage at the -1 position in the tRNAHis precursor. It will also be revealing to see how different aminoacyl-tRNA synthetases have adapted to discriminate between their cognate or related substrates and the now less distinctive tRNAHis." ...

A genetic 'gang of 4' drives spread of breast cancer

... tumor cells implanted in mice have shown that the abnormal activation of four genes drives the spread of brea...é and his colleagues had identified 18 genes whose abnormal activity is associated with breast cancer’s ability to spread to the lungs. In the new study publish...

New recommendations against a major opportunistic infection -- cryptococcosis

...y, the patients having neurological defects and/or abnormal consciousness, or abnormal neuroimaging at the time of diagnosis, have a worsened prognosis for survival. Along with these d...

Tumor-suppressor gene is critical for placenta development

...give rise to most of the placenta, resulting in an abnormal placenta and death of the embryos. The findings provide new insights into development of the placenta and into how the Rb gene blocks tumor growth. They also raise the possibility that this important tumor-suppressor gene might play a role in m...

Surgeons develop simpler way to cure atrial fibrillation

...tting a scar form. The ablation lines redirect the abnormal electrical currents responsible for atrial fibrill...th. For some patients, medications can control the abnormal heart rhythms and the risk of clotting associated with atrial fibrillation, but unlike the Cox-maze ...

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