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Tag: "transplanting" at biology news

Adult stem cells from human cord umbilical cord blood successfully engineered to make insulin

...ysicians might avoid the usual pitfall involved in transplanting cells or organs from other people — organ rejection, which requires organ recipients to take immune-suppressing drugs for the rest of their lives. Huge numbers of stem cells are thought to be required to create new organs. Researchers might remove...

Machine preservation may promote more organ sharing

... an important role in the Medical Center’s success transplanting kidneys at the outer limits of the ECD acceptance criteria, such as organs donated after cardiac death, preserved for more than 30 hours, or from donors over age 70. In previous studies with up to four years of follow-up data, Stratta has shown that ...

Study shows isolation of stem cells may lead to a treatment for hearing loss

...f developing strategies for cell replacement, i.e. transplanting these cochlear stem cells into the adult cochlea to affect hair cell replacement in the mouse, by extension, in humans?remarked Dr. Alagramam. In this paper, Drs. Miller and Alagramam offer further evidence for the existence of cochlear stem cells...

Penn researchers replace organ in adult mice using 'single-parent' stem cells

...nic stem cells entirely in the culture dish before transplanting them. The Penn researchers believe that using uniparental embryonic stem cells as a tissue source could provide a major advance in the alleviation of human disease, provided these results can be translated into human studies. ...

Targeting tumors the natural way

...hydrate, called anti-Gal. When scientists tried transplanting pig organs into primates, the anti-Gal antibodies bound to the alpha-Gal on the organ's cells, unleashing a potent immune response that caused immediate organ rejection. But true to natural cell recognition, the immune response occurs only when clust...

Transplanted photoreceptor precursor cells restore visual function in mice with retinal degeneration

...ase of the research. The goal was to learn whether transplanting cells isolated at a specific time period would sig...ill soon be able to investigate how the concept of transplanting photoreceptor precursors can be adapted to the human retina. "Perhaps within the next five years we ...

Human stem cells delay start of Lou Gehrig's disease in rats

Researchers at Johns Hopkins have shown that transplanting human stem cells into spinal cords of rats bred to duplicate Lou Gehrig's disease delays the start of nerve cell damage typical of the disease and slightly prolongs life. The grafted stem cells develop into nerve cells that make substantial connectio...

A transplant in time

... induced to begin producing these proteins, say by transplanting healthy tissue with the abilities that are lacking... Previous attempts to treat genetic disease by transplanting (mother to daughter) a spleen, an organ that can manufacture a number of the missing proteins in som...

Bone marrow may restore cells lost in vision diseases

...to be naturally replenished in the test animals by transplanting bone marrow cells from normal male mice into albino females with two different types of acute RPE injury. Bone marrow contains stem cells, which have the extraordinary abilities to home in on injuries and possibly regenerate other cell types in the ...

Adult stem cell research at UB targets damaged hearts

...es will use the swine model to investigate whether transplanting the model's own bone marrow mesenchymal stem cells (MSC) -- cells that have the capacity to develop into blood vessels, as well as other types of tissues -- into the down-regulated tissue can change the myocardial adaptive responses and improve the f...

Successful transplantation from pig embryos to mice

...ls as foreign, causing the body to reject them. By transplanting tissues from pig embryos into mice lacking proper immune systems, they determined that the best time frame for pancreatic tissue was about a third of the way through gestation (from 42 to 56 days). In the new study, Reisner's team wanted to see if s...

Cloned stem cells prove identical to fertilized stem cells

...est the integrity of these surviving stem cells by transplanting them into fertilized blastocysts and then observing the overall health of the resulting animal. Although these animals generated entirely from cloned stem cells appear to be fine, many scientists don't accept this result as definitive. Tobias Bramb...

Diabetes researchers pioneer islet cell xenotransplantation in primate studies

...at within the next three to five years, we will be transplanting patients with pig islets once we prove that it is safe." Using a relatively simple and reproducible method of obtaining large numbers of islets from neonatal pig pancreata developed at the U of A, the researchers then transplanted islets comprised o...

USC researchers track down the stem cells that create feathers

...ported stem cells from quail-feather follicles and transplanting them into a chicken host. (Quail cells can be differentiated from chicken cells by cellular markers.) This demonstrated that only the labeled cells were pluripotent. These stem cells, the researchers found, are well protected in the follicular base ...

Scientists discover the molecular switch for nerve cells' insulating jelly rolls

...have lost their myelin due to injury or disease by transplanting into, or turning on, a functioning neuregulin gene in nerve cells. "Is it possible that this same switch can reprogram a nerve cell that has lost myelin due to injury or disease to repair itself? That is a key question that our laboratory and others ...

Sickle cell disease corrected in human models using stem cell-based gene therapy

...isease. "Sickle cell disease can only be cured by transplanting healthy blood-forming stem cells from another individual, but this option is not available to most patients due to the difficulty in finding a compatible donor," explained Michel Sadelain, MD, PhD, of the Immunology Program at MSKCC and the study's s...

Stem cells' electric abilities might help their safe clinical use

...ved from human ESCs, suggesting the possibility of transplanting unlimited supplies of healthy, specialized cells into damaged organs. "We do not want to be taking any chances of tumor formation. Based on our previous research, we therefore decided to explore the existence of ion channels in pluripotent, or versa...

Bone marrow stem cells may heal hearts even years after heart attacks

...ear cells from the patient's own bone marrow, then transplanting these cells through the coronary artery feeding the damaged section of the heart muscle," Dr. El Oakley said. "The success of this approach will grow with time, yet more research is required to identify the ideal route of implantation, and the type o...

Research casts doubt on circulating stem cells

...entially treatable ?indeed, by the simple means of transplanting healthy bone marrow. For boys, DMD is the second most common hereditary disease. Due to a genetic defect, the muscles fail to produce properly functioning dystrophin, an important muscle protein. Those affected develop progressive muscle wasting. The...

Firefly protein lets researchers monitor molecule linked to cancer

...Piwnica-Worms tested the technique in live mice by transplanting genetically altered tumor cells and by using a technique that inserted the fused IKB/luciferase protein into liver cells only. They are currently working to develop a line of mice with the IKB/luciferase fusion built into its genetic code. In additi...

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