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Tag: "structure" at biology news

Man and mouse share genome structures

...heir study, the researchers analyzed the chromatin structure of the two shortest human chromosomes, numbers 21 ...apply the new technology to characterize chromatin structure in leukemic cells and gain insight into the molecular basis of disease. "The human genome still has...

University of Manchester makes made-to-measure skin and bones a reality using inkjet printers

... material repeatedly on top of each other untilthe structure is built. Each layer is just 10 microns thick (1,0...n fed into the printer and seeded directlyinto the structure as it is built. This avoids any 'sticking to thesurface' which is a major disadvantage of current me...

Protein discovery could unlock the secret to better TB treatment

.... Scientists believe that uncovering the molecular structure of this protein will lead the way to designing dru... Molecular Biology, a combined team discovered the structure of a protein known as resuscitation promoting factor (Rpf). Five versions of the Rpf protein exist i...

Priming embryonic stem cells to fulfill their promise

...xtracellular matrix proteins that form the support structure of almostall tissues. Bhatia, Chien, and Flaim focused on just one - theextracellular matrix."We kept the other factors constant and developed a miniaturizedtechnique to precisely vary extracellular matrix proteins as a way toidentify which combinati...

New, automated tool successfully classifies and relates proteins in unprecedented way

...ter could help scientistsidentify a common protein structure that enables those proteins togather in one part of the cell, according to Murphy. Getting thisinformation is critical to foil a disease like cancer, where you mightwant to identify and disable part of a tumor cell's machinery needed toprocess protei...

Elusive HIV shape change revealed; Key clue to how virus infects cells

... HIV to enter the cell and begin replicating. The structure of gp120 after it binds to the CD4 receptor and ch...roup. Harrison and Chen have now described gp120's structure before the shape change, yielding vital before-and-after information on how the molecule rearranges ...

Mouse brain cells rapidly recover after Alzheimer's plaques are cleared

...t the plaques often led to rapidrecovery of normal structure over a few days," says senior author DavidH. Holtz...s."The nerve cells' rapid ability to regain normal structure has Holtzmanand Brendza wondering if the nerve cells are constantly trying torestore their normal st...

Key molecule in plant photo-protection identified

...t the plaques often led to rapidrecovery of normal structure over a few days," says senior author DavidH. Holtz...s."The nerve cells' rapid ability to regain normal structure has Holtzmanand Brendza wondering if the nerve cells are constantly trying torestore their normal st...

Timing is everything: First step in protein building revealed

...line for a gene'sinstructions, it first alters its structure and then releases a factorknown as eIF1, a step necessary to let it continue reading the assemblyinstructions. Even though yeast are the most primitive relatives ofhumans, the protein-building machinery, or ribosomes, of each are quitesimilar. "Thei...

Researchers Uncover Key Step In Manufacture of Memory Protein

...the endoplasmic reticulum until it reaches another structure within the cell, the golgi apparatus. There, the proBDNF binds to CPE, which protrudes from special rafts of fatty, cholesterol-rich molecules known as lipids. If this binding process does not take place, proBDNF cannot be converted to its active for...

Plants respond similarly to signals from friends, enemies

... galls or knots on it. "We don't know the precise structure of Nematode factor, but it appears that the nematodes may have actually acquired genes from rhizobia to exploit this signal pathway," Bird says. ### The research was funded by the National Science Foundation and the North Carolina Research Station....

Research advances quest for HIV-1 vaccine

...performed a study examining the detailed molecular structure of the complex formed when 4E10 binds to gp41 and .... X-ray crystallography was used to determine the structure of the complex formed by association of 4E10 with a peptide fragment that is identical to the sectio...

Computers to be used to find blueprint for new influenza drug

... behave in highly complex interactions, the atomic structure of a suitable drug can be worked out. Using computer modelling in this way can be of great assistance in drug design. Normally drugs are produced by trial and error in a process that can take many years. Professor Williams and his colleague Dr Gus ...

Newly discovered virus linked to childhood lung disorders and Kawasaki disease

...re.Analysis of the New Haven coronavirus's genetic structure showed manysimilarities to that of a coronavirus r...ted when they found evidence ofthe virus's genetic structure in respiratory secretions from an infantwith classic signs of Kawasaki disease. In addition to heart...

Bound for destruction: Ubiquitination protects against improper Notch signaling

... cell’s nucleus. In addition to itseffects on wing structure in flies, Notch signaling is known to beimportant in a number of neural cell fate determination anddevelopmental processes, and is conserved in species from human toroundworm. In all processes in which it participates, Notch signalingshows the abilit...

Scientists find missing enzyme for tuberculosis iron scavenging pathway

...ivity in Rv1347c. By solving the three-dimensional structure of Rv1347c, Dr. Baker and his colleagues have disc...rely different role in M. tuberculosis. "What the structure showed, when combined with careful analysis of the sequence, its neighbors in the genome, and the fa...

Novel Enzyme Shows Potential As An Anti-HIV Target

...ought to influence transcription by regulating the structure and function of chromatin, which is an assembly of proteins (mostly histones) and DNA. Another, more widely accepted model proposes that histone acetylation controls transcription by recruiting cofactors required for transcription. Acetylation and d...

Gene therapy converts dead bone graft to new, living tissue

...a single brick at a time without tearing the whole structure apart. Schwarz's studies with mice showed their dead splints were quickly converted to new, healthy bone. He projects that the bone would be completely converted in just a year, and that a human bone might be completely converted in as little as fiv...

Molecular machine may lead to new drugs to combat human diseases

...le. When frozen, crystallized introns reveal their structure and the sites at which they bind with various mole...that attacks bacteria, to obtain an intron crystal structure trapped in the middle of the cutting and pasting cycle. As introns proceed through their work cycle,...

Automatic extraction of gene/protein biological functions from biomedical text

...(GO) from text using a shallow parser and sentence structure analysis techniques. When the gene/protein/family names and their functions are described in ACTOR (doer of action) and OBJECT (receiver of action) relationships, the corresponding GO-IDs are assigned to the genes/proteins/families. The gene/protein/...

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