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Tag: "regulates" at biology news

A gene's first 'kiss' sets off that affair known as puberty

...rly good understanding of how the endocrine system regulates the hormones involved, just how and when the brain activates this process has been a great mystery. An appreciation of puberty's deep-seated neurobiological mechanisms could, for instance, help prevent precocious or delayed puberty from occurring in ...

New binding target for oncogenic viral protein

... viruses interact with the cellular machinery that regulates cell division may lead to new insights into the pathways that cause cancer. This is an important step to designing new cancer treatment strategies that target these pathways," concluded Dr. Clurman. ...

Controversial drug shown to act on brain protein to cut alcohol use

...ce."By identifying the brain protein that Ibogaine regulates to reducealcohol consumption in rats, we have established a link between GDNFand reversal of addiction -- knowledge of a molecular mechanism thatshould allow development of a new class of drugs to treat addictionwithout Ibogaine's side effects," said...

Timing is everything: First step in protein building revealed

...mystery, the newdiscovery reveals exactly how eIF1 regulates the ribosome's activity.The research team has demonstrated that eIF1's mere presence on theyeast ribosome prevents the machinery from getting started. Only afterits release from the complex can the ribosome start making proteins."No one had any idea ...

Plants, animals share molecular growth mechanisms

...o know if this section is important and whether it regulates DIS3 or the whole WAVE complex." For growth and development biochemical processes to proceed normally, activators such as ARP 2/3 are needed to trigger actin filaments' formation and growth, Szymanski said. However, scientists don't know the specifi...

New Technique for Tracking Gene Regulators

...tified about 100 places whereCREB binds to DNA and regulates genes in humans, so scientists know itis important...enes. Trying toascertain which of these genes CREB regulates by more traditionalmethods, evaluating one gene at a time, would be too labor-intensive,expensive, a...

Combination therapy boosts effectiveness of telomere-directed cancer cell death

...meres function as a kind ofcounting mechanism that regulates how many times a cell can divide.In contrast to normal cells, cancer cells divide continuously anduncontrollably. Scientists know that cancer cells produce an enzyme,called telomerase, which prevents telomeres from getting too short socells can keep ...

GATA: a graphic alignment tool for comparative sequence analysis

...meres function as a kind ofcounting mechanism that regulates how many times a cell can divide.In contrast to normal cells, cancer cells divide continuously anduncontrollably. Scientists know that cancer cells produce an enzyme,called telomerase, which prevents telomeres from getting too short socells can keep ...

Research on Worms Yields Clues on Aging

...sulin signaling inside the body,which then in turn regulates longevity in the worms," Kornfeld says.Testing the anticonvulsants on longer-lived mutant worms, theresearchers found the drugs further extended their lives, although notto the same degree they extended the lives of worms with no mutations.That indic...

Novel Enzyme Shows Potential As An Anti-HIV Target

...Melanie Ott and colleagues identify an enzyme that regulates viral transcription by modifying Tat. The regulation of HIV genes depends on a complex interplay between proviral DNA, cellular proteins and transcription factors, and Tat. Unlike most transcription factors, Tat activates transcription by binding to...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

...ing cell type and cell death. "The let-7 microRNA regulates Ras by binding to the message for Ras and likely inhibits translation of the Ras protein," said Slack. "The microRNA does not revert a mutated Ras to normal; instead it acts like a brake on an accelerated Ras." Lung cancer currently has a poor progn...

Scientists discover the cellular roots of graying hair

...?The team also made mice lacking a gene, MITF that regulates Bcl2. Thesemice also went gray, but more gradually than did the mice that had noBcl2. The loss of MITF activity, the investigators say, appears to beimplicated in the mistaken differentiation of melanocyte stem cellsthat accompanies the stem cells?de...

Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery

...?The team also made mice lacking a gene, MITF that regulates Bcl2. Thesemice also went gray, but more gradually than did the mice that had noBcl2. The loss of MITF activity, the investigators say, appears to beimplicated in the mistaken differentiation of melanocyte stem cellsthat accompanies the stem cells?de...

Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.

...?The team also made mice lacking a gene, MITF that regulates Bcl2. Thesemice also went gray, but more gradually than did the mice that had noBcl2. The loss of MITF activity, the investigators say, appears to beimplicated in the mistaken differentiation of melanocyte stem cellsthat accompanies the stem cells?de...

Weill Cornell Research Reveals Secrets Of Trafficking Within Cells

...of results, he added. "It turns out that clathrin regulates endocytosis in a manner we never suspected before. It's not a linear relationship, where simply doubling the amount of clathrin doubles the speed at which vesicles are shuttled back and forth," Dr. Ryan explained. "Instead, it's what biochemists call...

Scientists reveal molecular secrets of the malaria parasite

...en the vertebrate host and themosquito. That motif regulates proteins that are switched on as theparasite enters the mosquito.Hall's group identified the gene regulation by comparing the genesexpressed in the sexual stage transcriptome with the proteomes of boththe sexual stage and a developmental stage in the...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

...processing pathway --the prenylation pathway ?that regulates Ras. Several years ago, Casey's laboratory was one of a handful to unravel how the prenylation pathway works. This accomplishment led pharmaceutical companies to test compounds that block another key player in the pathway, a protein called farnesylt...

Sequencing of marine bacterium will help study of cell communication

...irginia Tech, studies how cell-to-cell interaction regulates bacterial processes that include antibiotic or toxin production, biofilm formation, and bioluminescence. One of the longest studied models of quorum sensing is the bioluminescent marine bacterium V. fischeri. "It was selected by Drs. Ruby and Greenb...

Surprising findings reported about iron overload

...gene, called the HFE gene, which evidence suggests regulates iron absorption. "Hemochromatosis and iron overload are easily treatable if diagnosed early, but the simple blood test that could detect these conditions is not performed as part of routine medical exams," said Acton. Delaying treatment ?the weekly ...

Wisconsin researchers identify sleep gene

..., but details about the homeostatic mechanism that regulates the amount of sleep have been unclear," he says. In a four-year, round-the-clock search, researchers screened 9,000 mutated fruit flies, many of them supplied by Ganetsky's lab, and found one line of them that slept one-third the amount of normal fl...

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