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Tag: "rats" at biology news

Controversial drug shown to act on brain protein to cut alcohol use

...nowshown definitively in experiments with mice and rats that Ibogaine doesreduce alcohol consumption, and ...gaine reduced alcohol consumption. They inducedthe rats to consume alcohol in daily drinking sessions and thendemonstrated that their drinking declined prec...

Taking Aim With Nanoparticle PEBBLEs

...ent. In recent experiments with a small number of rats that had a type of brain cancer called 9L-gliosarc...ally live less than four months without treatment; rats die within about five days. When Kopelman's group treated rats with PEBBLEs that weren't even tailor...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

... cells and restore normal movements in monkeys and rats with a drug-induced form of Parkinson's disease. ...ry in their paws. Researchers say not only did the rats recover substantial degrees of function in their impaired forelimbs, continuous levels of L-dopa wer...

Alcohol's effects on gene expression in the central nervous system

...ventral tegmental area (VTA) of alcohol-preferring rats produced results suggesting that the reinforcing effects of alcohol are activating VTA dopamine neurons and producing changes in synaptic connections that resemble those that occur in memory and learning. "Learning and memory require enhanced synapt...

Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems

...und, IGF-1 (insulin-like growth factor 1) on adult rats and found paradoxical effects, according to Willia...span. The researchers developed a strain of dwarf rats that were naturally deficient in both growth hormone and in IGF-1. To mimic the rise in growth hormo...

NJIT Presidential Award winner takes stem cell research another step

...at aid stem cells. She performed animal studies on rats with bone defects; she also did cell-culture studies. Both showed that the biomaterials stimulated stem cells, producing new bone tissue and fully repairing the rats' bones. Arinzeh's second stem-cell discovery proved that adult stem cells taken fro...

UCSD team discovers specialized, rare heart stem cells in newborns

...he isl1+ progenitor cells in the tissue of newborn rats and mice, and then in heart tissue taken from five newborn human babies undergoing surgery for congenital heart defects. Study author Sylvia Evans, Ph.D., a member of the UCSD Institute of Molecular Medicine (IMM) and professor of pharmacology, and ...

Gene therapy for Parkinson's disease moves forward in animals

... cells and restore normal movements in monkeys and rats with a drug-induced form of Parkinson's disease. ...ry in their paws. Researchers say not only did the rats recover substantial degrees of function in their impaired forelimbs, continuous levels of L-dopa wer...

Rats infected as newborns grew up vulnerable to memory problems during an immune challenge

...iversity of Colorado at Boulder have reported that rats who experienced a one-time infection as newborns didn't learn as well as adult rats who were not infected as pups, after their immunity was challenged. The research is in February's Be...

Gene Therapy Cures Inherited Liver Disease In Rats

A single dose of gene-virus combination cured rats of a inherited liver disease in which lack of a gene causes the accumulation of bilirubin –which, untreated, results in jaundice and brain damage, said researchers at Baylor College of Medicine in a report in the Proceedings of the Natural Academy of...

Gene therapy promising for growing tooth-supporting bone

...genetic protein-7 (BMP-7) to large bone defects in rats in an attempt to turn on the body's own bone growth mechanisms. The study showed that animals that got the BMP-7 treatment produced nearly 50 percent more supporting bone around dental implants than those receiving the conventional treatment. "This ...

Harmful chemicals may reprogram gene response to estrogen

...lop the disease. The new research shows that when rats with a genetic predisposition to uterine tumors al... adult." The researchers used a special strain of rats with a defect in a gene called Tsc-2 (tuberous sclerosis complex 2) that made them more susceptible ...

Brain-injury rehabilitation depends on acetylcholine circuitry

...ir Group at UCSD have discovered. Their finding in rats could help enhance rehabilitation to recover from ...ehabilitation from brain injury, they first taught rats to reach for food pellets with their forepaws. In one group of animals, they then used a toxin to sp...

Scientists journey to southern Africa to unravel the secret world of elephant communication

...rate species, such as white-lipped frogs, kangaroo rats and golden moles. Seismic sensitivity also has been observed in elephant seals--huge marine mammals not related to elephants. But O'Connell-Rodwell was the first to suggest that a large land animal is capable of sending and receiving vibrational mes...

Compounds in plastic packaging act as environmental estrogens altering breast genes

...n in the mammary glands of young female laboratory rats exposed to the compounds through their mothers' mi...r of products. The studies of BPA and BBP in young rats were designed to see whether exposure to these hormonally active biological compounds could alter th...

After a time-shift, mixed signals from the circadian clock

...he researchers studied clock-resetting behavior in rats that were exposed to a six-hour delay of the light schedule, a shift that mimics a transition from the eastern U.S. to western Europe. By performing electrophysiological analysis of cells that constitute the central circadian clock, the researchers m...

Gene therapy cures inherited liver disease in rats

A single dose of gene-virus combination cured rats of a inherited liver disease in which lack of a gene causes the accumulation of bilirubin –which, untreated, results in jaundice and brain damage, said researchers at Baylor College of Medicine in a report in the Proceedings of the Natural Academy of...

Thai spice helps cut blood sugar swings

...ose levels, reducing insulin output In the study, rats were administered HCA prior to "mimicking a meal b...t be taken because the comparable dosage we use in rats is probably way too high for humans," he added. The 'South Beach' inference; speculation about HCA'...

Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes

...al to their earlier successes in treating diabetic rats with embryonic pig tissues. In those experiments,...dn't have to give anti-rejection drugs to diabetic rats treated with embryonic pig cell transplants. They had expected rats that received no immune suppress...

15 generations of untrained jocks, couch potatoes show big physiological adaptations

... what would happen if they took a single strain of rats ?meaning they all had the same basic genetic backg... on the basis of "continued selecting of untrained rats with either high- and low-running endurance." In this way, they could study the genetic role in endu...

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