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Tag: "protease" at biology news

Bound for destruction: Ubiquitination protects against improper Notch signaling

...in cell fatedetermination. Notch is activated bya protease that is present ubiquitously in the cell membrane. What haslong remained a mystery, however, is the question of how Notchreceptors that have not been activated by a ligand are protected fromdigestion by that protease. Now, in a report published in th...

HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs

... about a class of prescription drugs known as "HIV protease inhibitors." Drugs in this class go by the generic..."In no way does it mean patients shouldn't receive protease inhibitors," says Andrew Badley, M.D., associate director of Mayo Clinic's Program in Translational ...

Studies reveal methods viruses use to sidestep immune system

...attack against RIG-I, producing a protein called a protease to disrupt the cell's immune response that is othe...th drugs to try to limit infection." Drugs called protease inhibitors currently are used to treat patients infected with HIV and have also shown promise in tre...

Supercomputers to focus brains on AIDS dilemma

...e activity of the viral enzyme HIV protease, these protease inhibitors brought greatly extended life-spans to ... and other drugs, and protease, the target for the protease inhibitors that had proven so effective until the recent emergence of drug-resistant mutants. The n...

Asymptomatic HIV babies could use earlier treatment

... of a special type of antiretroviral drug called a protease inhibitor. They followed the children for the first three years of life, tracking at what age they developed AIDS and the rate of survival through their third birthday. As might be expected, infants born later in the study period were more likely to...

Enzyme's newly discovered role may make it target for arthritis treatment

...Shapiro SD, Simmons PM, Cheng AM, Pham CTN. Serine protease Cathepsin G regulates adhesion-dependent neutrophil effector functions by modulation integrin clustering. Immunity, June 7, 2005, 679-691. Funding from the Arthritis Foundation and the National Institutes of Health supported this research. ...

Study finds adult stem cells can replicate

...Shapiro SD, Simmons PM, Cheng AM, Pham CTN. Serine protease Cathepsin G regulates adhesion-dependent neutrophil effector functions by modulation integrin clustering. Immunity, June 7, 2005, 679-691. Funding from the Arthritis Foundation and the National Institutes of Health supported this research. ...

UIC developing drug for SARS

...tute of Allergy and Infectious Diseases to develop protease inhibitors that would block key enzymes in the SAR... study's principal investigator. "By administering protease inhibitors early, when feverish symptoms have started, the drugs could reduce the viral load and ame...

Protease inhibitors reach beyond HIV

...e programmed cell death of immune CD4 T cells. HIV protease inhibitors (PI) can block programmed cell death in virus-infected T cells in vitro, but have also been shown to induce programmed cell death at higher concentrations. The mechanisms for these paradoxical data are unclear, as is whether PI therapy wou...

Metal-containing compounds show promise as HIV weapon

...very low concentrations, the new molecules inhibit protease in infected cultured human cells with no obvious t...lacarboranes appeared to occupy the portion of the protease used to hold key proteins in place as part of the infective cycle of HIV, preventing the proteases f...

Protein behind autumn color splendor identified

...ociation with a Polish scientist, has identified a protease that degrades LHCII. The researchers assumed that the protease belonged to a certain family of proteases, the so-called FtsH proteases, and they used genetically m...

'Smart' nanoprobes light up disease

..., including the growing class of drugs that act as protease inhibitors. What is particularly powerful about the protease imaging probes described in this study is the combination of the contrast enhancement achievable thr...

Enzyme inhibitors block replication of SARS virus

...f inhibitors represents the most potent SARS virus protease inhibitors known today." The path to today's res...eplicate. Since then researchers have been testing protease inhibitors to lock up this site, known as SARS 3CLpro, and effectively stop the virus from infecting...

Gene-specific Ebola therapies protect non-human primates from lethal disease

...ences, may be more potent than anti-virals such as protease inhibitors, which seek to inhibit a protein needed for viral replication. Ebola virus causes hemorrhagic fever with case fatality rates as high as 80 percent in humans. The virus, which is infectious by aerosol (although more commonly spread throug...

Scientists develop a way to make the deadliest toxin known even more toxic

...ecific sites on the neurotoxin protein, increasing protease activity and enhancing the toxin's effect. In some...ase; before this study, a two-fold activation of a protease was referred to as a state of "superactivation." Proteases are enzymes that act as cellular catalyst...

Viral 'fitness' explains different resistance patterns to aids drugs

...V virus can develop. Yet patients taking unboosted protease inhibitors (PI) do not experience the peak risk of... author on the study. Both NNRTIs and non-boosted protease inhibitors are potent antiretroviral drugs (ARVs) with demonstrated effectiveness in suppressing the...

Computer simulation hints at new HIV drug target

... watched patiently as a few computer-simulated HIV protease molecules squirmed into more than 15,000 slightly ...hat are often seen after failure of treatment with protease inhibitors, drugs that block the action of the enzyme protease and prevent the virus from making mat...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

... watched patiently as a few computer-simulated HIV protease molecules squirmed into more than 15,000 slightly ...hat are often seen after failure of treatment with protease inhibitors, drugs that block the action of the enzyme protease and prevent the virus from making mat...

Novel therapy combinations gain ground in treating hepatitis

...etter patient outcomes. A new oral peptidomimetic protease inhibitor, VX-950, has previously shown substantial anti-viral effects in combination with the frequently used hepatitis therapy pegylated interferon (pegIFN). In this study, researchers evaluated the safety and antiviral response of VX-950 in combi...

Study details hepatitis C ability to block immune system response

...ks the production of type1 interferon by using its protease activity to destroy MAVS. By preventing infected cells from producing interferon, the virus inhibits the body's immune response against HCV, enabling it to persist. "Our new work shows that HCV does not induce interferon-? or antiviral interferon ...

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