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Tag: "preclinical" at biology news

UQ research heralds vaccine technology breakthrough

...of the children who succumb to it and die." With preclinical modelling in mice having been encouraging, Professor Tindle said clinical trials were forthcoming, leading the way to the vaccine becoming available in the clinic. He hoped it would become one of the vaccines given to all infants in their first three...

Dealing deadly cancers a knockout punch

...ultured cells and live animals. The results of the preclinical study showed that the combination of reovirus and ...ing synergistic action in further detail in future preclinical work. Another presentation at the Arizona conference reported on the use of Reolysin plus the can...

3 proteins may play important role in nerve-cell repair

...find out whether the approach can be translated in preclinical animal models of stroke or spinal cord injury." ...

Massey researchers induce cell death in leukemia

...th University Massey Cancer Center today presented preclinical research at the American Association of Cancer Res...two established CLL cell lines provided additional preclinical evidence that bortezomib interacts synergistically with both agents to induce cell death in human CL...

Prion disease treatable if caught early

... still possible. "Eventually it may also enable preclinical testing of therapeutic strategies through cognitive endpoints. These data now lead to the hope that early intervention in human prion disease will not only halt clinical progression but allow reversal of early behavioral and cognitive abnormalities,"...

New drug blocks influenza, including bird flu virus

...nfection. The team hopes to move the research into preclinical phase as quickly as possible. Currently, there are a few effective antiviral medications on the market for influenza, but they are beginning to show signs that they are losing their effectiveness, and scientists and health professionals worry that...

Muscle and bone from an ink-jet printer

...ineered regenerative therapies. In preparation for preclinical studies, the Pittsburgh researchers are following up this work by combining the versatile ink-jet system with advanced live cell imaging developed at Carnegie Mellon’s Robotics Institute and Molecular Biosensor and Imaging Center to further understan...

'Trojan Horse' agent halts bone metastasis in mice

... bone tumors in 50 percent of the mice tested in a preclinical study, providing early evidence that it could treat, or thwart, growth of tumors in bone, a common destination for a number of cancers when they start to spread. Researchers at The University of Texas M. D. Anderson Cancer Center reported in the jou...

Report calls for improved monoclonal antibodies against solid tumors

...ructs in clinical practice, clinical research, and preclinical research.?...

Spelling out cancer on the nanoscale

... needle aspirates from hematopoetic tumor cells in preclinical transgenic mouse models. The nano-fluidic system physically separates the proteins in very small capillary tubes and then uses antibodies for protein detection. It was also tested on human lymphoma samples. In previous work, the Felsher group ...

New mechanism underlying pain found

...he root-cause of chronic neuropathic pain, and the preclinical validation of new targets for pharmaceutical thera...'s heart rate. "What we have shown in our early preclinical research is that we can inhibit the inappropriate neuronal activity and resulting sensitivity that f...

Proteins anchor memories in our brain

...one, PhD, director of the UCSF Diabetes Center, in preclinical studies to see if T cell autoimmune attacks on IRBP can be modulated to prevent the autoimmune eye disease. ...

Autoimmune disease triggered if T cells miss a single protein early on

...one, PhD, director of the UCSF Diabetes Center, in preclinical studies to see if T cell autoimmune attacks on IRBP can be modulated to prevent the autoimmune eye disease. ...

Restoring tamoxifen sensitivity in resistant breast cancer cells

...xifen. If successful, this could set the stage for preclinical studies. ...

Bacterial protein shows promise in treating intestinal parasites

...e the spectrum of activity of Cry5B as part of its preclinical development as a human therapeutic."...

Jefferson scientists identify gene mutation potentially involved in breast cancer initiation

...estrogen treatment. "In essence, we have created a preclinical model in which to study the role of estrogen and caveolin deficiency in breast cancer development," he says. "It's a new signaling pathway for understanding the pathogenesis of human breast cancer with caveolin gene inactivation as the initiating ste...

Stem cell expansion

...refore turned to nonhuman primates, an established preclinical model for HSC transplantation and gene therapy. The team showed that HOXB4 over-expression in populations of cells enriched for stem cells (i.e. those that are used for transplantation) for 6-9 days prior to transplantation greatly improved their ...

Speeding discovery of the 'human cancer genome'

... mouse model now offers an "excellent setting" for preclinical tests of the potential of cIAP1 and Yap as targets for new cancer therapies, they added. Taken together, the papers demonstrate a general principle with real importance for cancer patients, Chin said. "Robust, stringent and biologically relevan...

Tramiprosate (Alzhemed? preclinical results published in Neurobiology of Aging

...ublished an online version of a publication on the preclinical development of tramiprosate (3-amino-1-propanesulf...Strategic Planning and Scientific Affairs. "These preclinical results indicate that Alzhemed TM binds preferentially to soluble amyloid β peptide, interferes wit...

Trial success for diabetic nerve therapy

... caused by diabetes has shown promising results in preclinical and early patient trials. The University of Manch...nds and feet ?caused by the disease. The positive preclinical results ?reported in the journal Diabetes ?are further evidence that the research could lead to a ne...

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