Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration
...cientists for hundreds of years: regeneration. In pinpointing the genes, the U School of Medicine researchers have established the planarian as a genetically sound model for human biology, to take its place alongside Drosophila (fruit flies), C.elegans (another worm), zebrafish, and mice. The study, to be publ...Snapin: A protein with therapy potential for autism
...s a protein that shapes the dendrites, but also in pinpointing a drug target where one can regulate the interaction of snapin with cypin," Firestein explained. Both of these proteins have many other functions in the nerve cell environment and elsewhere in the body. "We need to change cypin's function for branch...Gambling monkeys give insight into neural machinery of risk
...hat's involved in that process." However, he said, pinpointing a key region involved in risk assessment will enable further studies to map that circuitry. "It's going to be interesting to trace this circuitry to see which parts of the brain are signaling something about subjective utility and which parts of the...Customized gene chip provides rapid detection of genetic changes in children's cancer
... for neuroblastoma prognosis," said Dr. Maris. In pinpointing specific regions of chromosomes with loss in DNA, the technology may help confirm a clinical diagnosis, said Saul Surrey, Ph.D., professor of medicine and Associate Director of Research at the Cardeza Foundation for Hematologic Research and the Divis...Scientists directly view immune cells interacting to avert autoimmunity
...immune diseases and organ transplant rejection. By pinpointing where and how regulatory T cells work in vivo in mouse models, the researchers hope to better adapt the regulatory T cells for therapeutic use in the future. For example, Tang said, one can imagine that at the early stage of an autoimmune attack, it ...Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
...the new, real-time tracking method is very good at pinpointing exactly when and where rejection is taking place. The researchers used a heterotropic heart model to study organ rejection. In this model, a rat receives a second functional heart, which is grafted into its abdomen. The rat's native heart functions ...New light microscope sharpens scientists' focus
... As Betzig's work in the early nineties had shown, pinpointing the center of these fuzzy balls can identify the location of the labeled protein to the nanometer scale. But if the molecules are too close together ?and usually they are ?the fuzzy edges appear to overlap and the microscope cannot discriminate betwe...International team analyzes human genetic variation in key immune region
..., multiple sclerosis and Crohn's disease. However, pinpointing the specific changes that are causative in these diseases has been complicated by two factors: the extremely high degree of genetic diversity that exists in the MHC among different individuals and the tendency for multiple genetic differences in this......ding the processes by which they form will require pinpointing the forks in the road where things go wrong." ...