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Tag: "parkinson" at biology news

Scientists detect probable genetic cause of some Parkinson's disease cases

Two new studies strongly suggest that a.mutation in a recently discovered gene is the most common genetic cause.of Parkinson's disease identified to date. The discovery by an.international research team provides fresh evidence that genetics may.contribute to the development of some cases of Parkinson's disease. The.findings could lead to the development of a genetic test to detect the.mutation in...

Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates

The replenishment of missing neurons in the.brain as a treatment for Parkinson disease reached the stage of human.trials over 15 years ago, however the field is still in its infancy..Researchers from Kyoto University have now shown that.dopamine-producing neurons (DA neurons) generated from monkey embryonic.stem cells and transplanted into areas of the brain where these neurons.have degenerated i...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

An international team of scientists has used gene therapy in two separate studies to renew brain cells and restore normal movements in monkeys and rats with a drug-induced form of Parkinson's disease. .. .. By inserting corrective genes into the brain, scientists studying small monkeys called ma...

Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimer's, Parkinson's Disease

To understand the formation of the brain-clogging deposits that cause such disorders as Alzheimer's and Parkinson's diseases, Duke University chemists have figured out how to capture and "micromanipulate" the single molecular building blocks of the deposits. . .. The researchers led by Boris Akhremitchev are using the infinitesimal tip of a customized atomic force microscope (AFM) to captur...

Gene therapy for Parkinson's disease moves forward in animals

An international team of scientists has used gene therapy in two separate studies to renew brain cells and restore normal movements in monkeys and rats with a drug-induced form of Parkinson's disease. .. .. By inserting corrective genes into the brain, scientists studying small monkeys called ma...

Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease

Investigators report safety findings and statistically significant improvements in clinical measures of movement, PET Scans at 19th Annual Symposia on the Etiology, Pathogenesis and Treatment of Parkinson's Disease and Other Movement DisordersNeurologix's Phase I trial showed positive interim results in patients with Parkinson's disease. One year following treatment, patients exhibited a statist...

First Whole Genome Map of Genetic Variability in Parkinson’s Disease

In findings with implications for pandemic influenza, a new study reports for the first time that a less-virulent strain of avian influenza virus can spread from poultry to humans. The research appears in the October 1 issue of The Journal of Infectious Diseases, now available online. . Crossing the species barrier is an important step in the development of a flu virus with pandemic potential. P...

Renewed hope for Parkinson's patients

Research led by biologists at the University of California, Berkeley, has found that damage to a cell's DNA sets off a chain reaction that leads to the increased expression of a marker recognized by the body's immune system. . .. "Our study is the first to show that there are mechanisms in place for the immune system to ide...

Amphetamines reverse Parkinson's disease symptoms in mice

Amphetamines, including the drug popularly known as Ecstasy, can reverse the symptoms of Parkinson's disease in mice with an acute form of the condition, according to new research at Duke University Medical Center. .. . The new study also sh...

UCLA scientists find male gene in brain area targeted by Parkinson's

UCLA scientists have discovered that a sex gene responsible for making embryos male and forming the testes is also produced by the brain region targeted by Parkinson's disease. Published in the Feb. 21 edition of Current Biology, the new research may explain why more men than women develop the degenerative disorder, which afflicts roughly 1 million Americans. . "Men are 1.5 times more likely to...

Gene therapy 'turns off' mutation linked to Parkinson's disease

A group of Northwestern University researchers is developing a novel gene therapy aimed at selectively turning off one of the genes involved in the development of Parkinson's disease. . .. Bohn is Medical Research Council Professor and director of the neurobiology program at Children's Memorial Research Center and professor of pediatrics and of molecular pharmacology and biological...

Key stress protein linked to toxicities responsible for Parkinson's, Alzheimer's

Researchers at the Burnham Institute for Medical Research have discovered a mechanistic link between cellular stress caused by free radicals and accumulation of misfolded proteins that lead to nerve cell injury and death in neurodegenerative disorders such as Alzheimer's and Parkinson's Disease. . That link is Protein Disulphide Isomerase (PDI), a chaperone protein that is necessary for proper...

Parkinson's disease mechanism discovered

Howard Hughes Medical Institute researchers have pinpointed defects in a critical cellular pathway that can lead to the death of dopamine-producing nerve cells and ultimately Parkinson's symptoms. Their studies have also identified a new way to rescue dying neurons in several animal models of Parkinson's disease. . .. The research team, which included Howard Hughes Medical Institute investigat...

Dopamine drug leads to new neurons and recovery of function in rat model of Parkinson's

In preliminary results, researchers have shown that a drug which mimics the effects of the nerve-signaling chemical dopamine causes new neurons to develop in the part of the brain where cells are lost in Parkinson's disease (PD). The drug also led to long-lasting recovery of function in an animal model of PD. The findings may lead to new ways of treating PD and other neurodegenerative diseases....

Parkinson's mutation stunts neurons

Mutations in a key brain protein known to underlie a form of Parkinson's disease (PD) wreaks its damage by stunting the normal growth and branching of neurons, researchers have found. They have pinpointed the malfunction of the protein made by mutant forms of the gene called LRRK2 and how it affects neurons, ultimately leading to their death. The loss of dopamine-producing neurons is central to t...

Transplanted brain cells hold promise for Parkinson's disease

Transplanted neural stem cells hold promise for reducing the destruction of dopaminergic cells that occurs in Parkinson’s disease and for replacing cells lost to the disease, scientists say. . .. "We are very cautious but to us, it’s an indication that stem cells have promise for Parkinson’s...

NIH announces phase III clinical trial of creatine for Parkinson's disease

The NIH National Institute of Neurological Disorders and Stroke (NINDS) today is launching a large-scale clinical trial to learn if the nutritional supplement creatine can slow the progression of Parkinson's disease (PD). While creatine is not an approved therapy for PD or any other condition, it is widely thought to improve exercise performance. The potential benefit of creatine for PD was ide...

Proteins important in Alzheimer's, Parkinson's disease travel in the slow lane

Using a novel video-imaging system, researchers at the University of Pennsylvania School of Medicine have been able to observe proteins important in Alzheimer’s and Parkinson’s disease moving along axons, extensions of nerve cells that carry proteins away from the cell body. Understanding this process of axonal transport is important for studying many neurodegenerative diseases. The study appeare...

Implanting dopamine generators in brain cells obtains improvement in Parkinson's in monkeys

Implanting dopamine generators (dopaminergics) in brain cells has produced improvement in the symptoms in Parkinson's, according to the results of tests carried out with monkeys by the Navarra University Hospital, led by Dr María Rosario Luquin Piudo, neurologist at the Hospital and at the other Navarra University-based medical centre, CIMA (the Research Centre for Applied Medicine). . , and have...

Gene therapy study shows safety and statistically significant improvement in Parkinson's disease

. The open label Phase 1 study, conducted in 12 patients with advanced Parkinson’s disease demonstrated both a lack of adverse events related to the gene therapy procedure and statistically significant improvements from baseline in both clinical symptoms and abnorm...

Researchers identify protein pathway involved in Parkinson disease development

. Parkinson disease is a degenerative disorder of the central nervous system resulting from the loss of neurons in the brain that produce dopamine. This lower...