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Tag: "makes" at biology news

Chemists create 'Superbowl' molecule; May lead to better health

...the hole at the top of the molecule smaller, which makes it more difficult for things to pass in and out. This is ideal if you're trying to capture certain molecules and hold them until they're ready for release, the researcher says. Superbowl molecules are similar in function to buckyballs, the experimen...

Bioartificial kidney under study at MCG

...en and energy to perform their endless task, which makes them easy targets in the ICU, Dr. Szerlip explains. As examples, kidneys can become ischemic and begin to fail if blood pressure drops because of a long surgery with significant blood loss. Infection can further reduce blood flow to the kidneys. Iron...

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...t offers the opportunity to try to understand what makes these fatty acids so deleterious, and what we need...rans fats caused greater activity of the gene that makes PGC-1beta co-activator than did unsaturated fats. The research also showed that when the fats trigg...

Yellowstone microbes fueled by hydrogen, according to U. of Colorado study

...ar."Salmonella metabolizes hydrogen in the gut. It makes me wonder howmany different kinds of microbes out there are metabolizing hydrogen inextreme environments."Instead of relying on traditional techniques of microbiology thatutilize cultures grown in the lab, the CU-Boulder team used methodologydevelope...

New binding target for oncogenic viral protein

...Fbw7 is itself an important tumor suppressor which makes it an attractive choice for inactivation by Large T," explained Dr. Markus Welcker, the study's first author. The research appears as the "Paper of the Week" in the March 4 issue of the Journal of Biological Chemistry, an American Society for Bioche...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

... need to understand that prenatal undernourishment makes a person permanently at higher risk for developing diabetes, so prenatal care is important," Dr. Patti said. "Moreover, if someone was born with low weight, they need to pay special attention to prevention tactics, including exercise and weight contr...

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

... when muscles do not receive enough blood, thebody makes growth factors that stimulate the bone marrow to releasestem cells that "home" to the muscle that is not getting enough blood.These stem cells include endothelial progenitor cells (EPCs), which isthe type of cell needed to make new blood vessels and ...

Neuronal 'traffic jam' marks early Alzheimer's disease

...berrant form of amyloid beta (A-beta) peptide that makes up the plaques that surround the neurons of people...tion and plaque deposition," said Goldstein. "This makes it clear there is some mechanistic connection between the transport deficit and plaque deposition. ...

UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims

...ns the drug ads for validity, but the sheer volume makes it difficult to adequately check many of the ads. For example, in 2002, the FDA screened more than 34,000 ads. Journals included in the study: American Journal of Psychiatry, Annals of Emergency Medicine, Annals of Internal Medicine, Annals of Surge...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

...me data will help researchers find more about what makes some people innately resistant to infection by E. histolytica, and what acquired immune responses can protect people from re-infection. Says Petri: "The genome project has spawned rapid discovery of the parasite's mechanisms for replication, gene exp...

“Nano-scissors?laser shows precise surgical capability

...on’tdamage anything. The pulse’s very short length makes the photons in thelaser concentrate in one area, delivering a lot of power to a tiny,specific volume without damaging surrounding tissue.?Once cut, the axons vaporized, and no other tissue was harmed.To assure the axons were actually cut, and their d...

Study finds more than one-third of human genome regulated by RNA

...their targets.To produce a protein, the cell first makes a template for that proteinby constructing a molecule called messenger RNA. MicroRNAs inhibitprotein production by associating themselves with particular messengerRNAs, thereby reducing the amount of protein that's ultimatelyproduced. In this study, ...

NYU researchers simulate molecular biological clock

...their targets.To produce a protein, the cell first makes a template for that proteinby constructing a molecule called messenger RNA. MicroRNAs inhibitprotein production by associating themselves with particular messengerRNAs, thereby reducing the amount of protein that's ultimatelyproduced. In this study, ...

Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey

...howsome bacteria know when to produce a toxin that makes infection moresevere. It may lead to the design of new toxin inhibitors. “Blocking orinterfering with a bacterium’s “detection?mechanism, should preventtoxin production and limit the severity of infection,?says MichaelGilmore, PhD, lead author of the...

Molecular machine may lead to new drugs to combat human diseases

..., an infection of tissues in the oral cavity. This makes introns a potential target for therapeutics against these diseases by using a strategy called targeted trans-splicing in which introns are manipulated to cut out malfunctioning genes. Introns' unique capability of cutting and pasting apparently has ...

Sea skate experiment sheds light on human cell transport

...cells and other animals ?including humans ?is what makes the findings exciting." In type 1 diabetes, cells lose their ability to transport glucose. Goldstein and Musch say their findings could explain the problem. People with type 1 diabetes don't produce insulin. Without that hormone, vesicles aren't ins...

An HIV Protein Plays a Surprising Role in Gene Activation

...longation. And it may be this resourcefulness that makes Tat such a potent activator—and HIV so hard to control. (For more on Tat's role in HIV transcription, see “Novel Enzyme Shows Potential as an Anti-HIV Target?[DOI: 10.1371/journal.pbio.0030074] and “A New Paradigm in Eukaryotic Biology: HIV Tat and t...

Gene variations explain drug dose required to control seizures

...use and in what dose," Goldstein said. "This study makes clear that such an approach is not sufficient. People with epilepsy are genetically different from one another, and some of those differences affect their responses to drugs in a predictable manner. "We are beginning to understand how genetics can b...

BRCA1 causes ovarian cancer through indirect, biochemical route

...hat may be correctable or preventable. That's what makes this finding so exciting." Dubeau points out that women with BRCA1 mutations are also predisposed to cancers of the fallopian tubes, and that the mice with mutated BRCA1 genes in their granulosa cells developed tumors there as well. "This not only u...

Poplar trees redirect resources in response to simulated attack

...sure to jasmonic acid, a potent plant hormone that makes the plant 'think' it's under attack, it partitions more of its carbohydrates to the roots for storage. ...

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