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Tag: "leukemia" at biology news

Researchers discover inherited mutation for leukemia

... increases a person's risk for chronic lymphocytic leukemia (CLL), one of the most common forms of the disease...sease expected this year in the United States. The leukemia is slightly more common in men than women, and typically strikes people who are in their 50s, 60s an...

Studies to find better ways to preserve human eggs, ovarian tissue under way

...oductive Laboratories of Augusta. Treatment for leukemia and cervical, ovarian, breast or other cancers often leaves women infertile because systemic chemotherapy and more focused radiation therapy, designed to kill rapidly spreading cancer cells, also can destroy dynamic reproductive tissue. “I don’t ...

Research shows cord blood comparable to matched bone marrow

..., the investigators compared outcomes of pediatric leukemia patients who received unrelated bone marrow transp...e with little notice is a great advantage. Today, leukemia patients can wait months for an appropriately matched bone marrow donor, during which time their dis...

Researchers shed light on mechanism of action used by anti-cancer drug

...ournal of Biologic Chemistry, showed that in human leukemia cells, sorafenib lethality was less a consequence ...esent work, Grant and his team found that in human leukemia cells, sorafenib induces a process known as endoplasmic reticulum (ER) stress, which results from ac...

Cancer patients monitor fatigue in real time

... example, an adult diagnosed with acute myelocytic leukemia may seek medical care because of the extreme fatigue," Hacker said. "Cancer can cause fatigue directly or indirectly by spreading to the bone marrow, causing anemia and by forming toxic substances in the body that interfere with normal cell functions...

Leukemia drug turns mini-molecules up, cancer genes down

...orm of vitamin A used to treat acute promyelocytic leukemia induces changes in an unusual class of small molec...RA raises the levels of three particular miRNAs in leukemia cells and that this rise coincides with a fall in activity of two important cancer-causing genes. Th...

Major gene study uncovers secrets of leukemia

... to the formation of pediatric acute lymphoblastic leukemia (ALL), the most common cancer in children. The dis.... The St. Jude group used this approach to analyze leukemia samples from 242 pediatric patients with ALL. This identified an unexpectedly high frequency of muta...

Brown cancer biologists identify major player in cell growth

...te blood cells. If those cells develop abnormally, leukemia results. But the exact function of GABP in the cell cycle wasn't known. Rosmarin wanted to find out. So he and members of his laboratory created mice that carried a mutation -- tiny DNA sequences were inserted into their GABP-making gene. These DN...

Synthetic peptide targets latent papilloma virus infections

...ononucleosis and an aggressive form of lymphocytic leukemia called Burkitt's leukemia, and the Kaposi's sarcoma virus, which can develop to cancer in those with AIDS. ...

Massey researchers induce cell death in leukemia

... new combination treatment for chronic lymphocytic leukemia (CLL). In this study, led by Steven Grant, M.D., Massey's associate director of translational research, interactions between bortezomib and romidepsin (Gloucester Pharmaceuticals) and bortezomib with belinostat (aka PXD101 from CuraGen Corporation...

Researchers first to map gene that regulates adult stem cell growth

...healthy stem cells into cancerous ones, such as in leukemia and lymphomas. If the gene does in fact play such a role, it is possible that it also could provide the keys to new therapies. Van Zant describes his discovery as an elation. He worked on the project for six years with Ying Liang, a former graduate...

Knocking out survival protein could aid leukemia treatment

An effective way to fight leukemia might be to knock out a specific protein that prot...gainst drug-resistant forms of chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL). The two forms of cancer kill about 20,500 Americans ye...

Leukemic cells find safe haven in bone marrow

...o help cure some children with acute lymphoblastic leukemia (ALL) because molecules released by certain cells ... niche of the bone marrow might be the reason that leukemia recurs in some children who have been treated with this drug," said Dario Campana, M.D., Ph.D., a me...

Cancer scientists create 'human' leukemia process to map how disease begins, progresses

... to convert normal human blood cells into "human" leukemia stem cells. The converted cells, when transplanted...Genetics, University of Toronto, said: "Most human leukemia research involves studying a patient's diseased cells or a cell line grown from those cells. However...

Drug treatment improves learning in mice with Down syndrome symptoms, Stanford/Packard study shows

...t is also associated with childhood heart disease, leukemia and early onset Alzheimer’s disease. The researchers used a mouse model of Down syndrome for their study in which about 150 genes are triplicated. The mice exhibit many of the cognitive problems that afflict human Down syndrome patients. Fernandez...

Lost in the labyrinth

...n the development of stem cells frequently lead to leukemia and other diseases, the work should give researchers a new handle on processes within cells that lead to cancer. The work is published in this week's online issue of Nature Immunology. Over the past decades, molecular biologists have identified seve...

Study uncovers mutation responsible for Noonan Syndrome

...onan syndrome are also mutated in several types of leukemia and solid tumors, our findings may also expand our knowledge of cancer pathways." ...

Plant-derived molecules, genetic manipulation point to future chemoprevention methods

...terpenoid CDDO-MA, currently undergoing trails for leukemia and solid tumors (sponsored by Reata Pharmaceutica...variant CDDO-ME are undergoing clinical trials for leukemia and solid tumors. Beginning at 10 weeks of age, mice that were genetically altered to become sus...

'Tribbles' protein implicated in common and aggressive form of leukemia

...ed a new protein associated with acute myelogenous leukemia (AML). Several lines of evidence point to a protei...cells in the blood. AML is the most common type of leukemia in adults, with an estimated 10,100 new cases reported each year. Pear, also a researcher in the...

Pair of microRNA molecules controls major oncogene in most common leukemia

...for a dangerous form of B-cell chronic lymphocytic leukemia (B-CLL), the most common human leukemia in the world. Their findings, published in the December 15 issue of Cancer Research, demonstrate t...

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