Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
...levels rise or drop in response to glucose levels, keeping everything in balance. But diabetes is a complex metabolic disorder with numerous players such as high levels of blood glucose, cholesterol and other lipids. "The challenge is to figure out which factors are a primary cause of diabetes and which are ...Vital step in cellular migration described by UCSD medical researchers
...d extend protrusions in all directions, in essence keeping the cell in one place. Until now, researchers have had limited understanding of the molecular mechanism that inhibits Rac activity in the back of the cell, to maintain directional movement. In laboratory experiments with human and animal cells, the ...Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
...achman suggests the vaccine might prove helpful in keeping humanHER2/neu tumors from metastasizing, or spreading, but adds that thisnotion must be tested in human clinical trials.Lachman believes that the vaccine will address two additional safetyconsiderations “because it is built of RNA that cannot insert ...A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
...achman suggests the vaccine might prove helpful in keeping humanHER2/neu tumors from metastasizing, or spreading, but adds that thisnotion must be tested in human clinical trials.Lachman believes that the vaccine will address two additional safetyconsiderations “because it is built of RNA that cannot insert ...Development of portable infectious disease detector
...eir home fertility tester, Pria kept costs down by keeping theirsystem as simple as possible. Instead of trying to squeeze everythingonto a single chip, Pria designers started with a desktop diagnosticsystem and shrank it down into a device about the size of a coffee cup.One of the cost-saving aspects of the...Why do insects stop 'breathing'? To avoid damage from too much oxygen, say researchers
...a long time. "In other words, insects are actively keeping oxygen out and doing it in a way that shows they know how to measure oxygen," Bradley said. "Their behavior indicates they are regulating oxygen." Bradley and Hetz will next work on developing a comprehensive model of insect breathing. "We'd like to...New SARS Protein Linked To Important Cell Doorway
...re proteins for transport to the cell surface--and keeping it there. Plans for follow-up include studies of a recently produced version of the SARS virus where orf7a has been genetically knocked out. Scientists hope to use it to learn what orf7a does for the virus and how important it is to the virus' abili...MSI releases 'moleculizer' - a new approach to simulation of intracellular biochemical networks
...on of the future behaviors of biologicalsystems.In keeping with the MSI's support for an open source biology,Moleculizer will be made freely available under the GNU Lesser GeneralPublic License.Nature Biotechnology is "a monthly journal covering the science andbusiness of biotechnology. It publishes new conc...Newly Discovered Compound Blocks Known Cancer-Causing Protein
...n that has been shown to be an important player in keeping a cancer-causing gene called 'Ras' turned on inside cells," said Casey. Ras is a normal genetic component of the cell, but mutations in the gene can cause it to become stuck in an "on" position, promoting uncontrolled cell growth. Mutations in Ras t...New RNA polymerase discovered in plants
...ntegrity of the Arabidopsis genome, principally in keeping the silent DNA silent," Pikaard said. "Plants can get by without Pol IV, whereas they can't do without the other three. We don't see anything obviously like Pol IV in any other genome, but it's possible it might have been overlooked." While Pikaard ...Unexpressed But Indispensable -- The DNA Sequences That Control Development
...used different regional patterns of expression, in keeping with their presumed roles in distinct developmental processes. The discovery of these developmentally important sequences opens several avenues of new research. For example, analyzing the sequence and location of these CNEs may help point the way to...McGill researchers shed light on formation of carcinogen in food
...layan, "food companies and government agencies are keeping a close eye on the situation. It's important to know exactly what chemicals are present in food, and to understand how they form during processing." ...Brain-mapping technique aids understanding of sleep, wakefulness
...estern found that a type of neuron responsible for keeping animals awake receives inhibitory signals from neu... specific region of the brain are doing just that, keeping the animals asleep." The researchers also found that during wakefulness, orexin neurons activate ce...Some Brain Cells 'Change Channels' To Fine-tune The Message
...channel swap might be accomplishing more than just keeping the cell alive. "Calcium turns some processes on, ...t be doing more than just protecting themselves by keeping calcium out." In some cases, protection might be enough of a goal. In people with Lou Gehrig's dise...Red delicious, Northern Spy apples have most antioxidants, chemists find
Some apples might do a better job of keeping the doctor away than others, according to Canadian researchers who analyzed eight popular varieties of the fruit. Red Delicious, Northern Spy and Ida Red, they say, pack a greater wallop of disease-fighting antioxidants than other apples studied. Th...Two chemicals boost immune cells' ability to fight HIV without gene therapy
...at work by switching telomerase on permanently and keeping the immune cells young and strong in their fight against infection," said Effros. "These therapies are also easier to develop than gene-therapy drugs." The research was supported by a grant from the National Institute of Allergy and Infectious Disea...Some Brain Cells Change Channels
...channel swap might be accomplishing more than just keeping the cell alive. "Calcium turns some processes on,...t be doing more than just protecting themselves by keeping calcium out." In some cases, protection might be enough of a goal. In people with Lou Gehrig's dise...Research Reveals Functions Of Harmful Shellfish Pathogens
...Del., are studying these bacteria with the goal of keeping them out of shellfish. Gary P. Richards, a microbiologist and the center's lead scientist, wants to identify Vibrio enzymes that may help the organism enter shellfish--and, eventually, a human host. Richards, who leads a group of scientists from Del...Researchers reveal secret of key protein in brain and heart function
...ns inside the cell critical to nerve signaling and keeping them close to N-methyl-D-asparate (NMDA) receptors at the cell surface. NMDA receptors help usher in a neurotransmitter called glutamate that is essential for learning and memory and also plays a role in drug addiction. A similar scaffolding mechanis......y promoted the use of chilli peppers as a means of keeping elephants, buffalo, and other species away from important sources of human food, but has also introduced a viable cash crop to the economy of African nations. "Chilli peppers are unpalatable to crop-raiding mammals, so they give farmers an economica...