Researchers seek to discover what really happens when a virus enters the body
...nal and image processing. As Duca, a biophysicist, introduces viruses into cells in a laboratory dish, she infects only the cell's center. Then, she and Bell, who is also currently associated with VBI as one of its faculty fellows, study the response as the virus moves outward. Their method differs from convent...Gene therapy to lower blood pressure just enough
A newly developed virus that introduces a blood pressure-lowering gene into cells and enables that gene to maintain blood pressure at healthy levels for four months promises to take gene therapy for the disorder a step closer to reality, said researchers at Baylor College of Medicine in a ...Stressed cells spark DNA repair missteps and speed evolution
...r, when the process goes wrong, the repair process introduces errors into the DNA. When graduate student Rebecca G. Ponder set up a system so that she could control where the break in DNA occurred, she found that errors occurred right next to the break in the stressed cells, and that the rate of errors was 6,...Grand Challenges in Global Health initiative funds Yale project
...loped at the Institute for Research in Biomedicine introduces cells from human umbilical cord blood into mice to establish a human immune system. "Using this technology and the genetic modification of the mouse, we will end up with a reasonably faithful replica of the human immune system," said Flavell. The pr...Geoscientists follow arsenic from chicken feed to streambeds
...c arsenic in to the subsurface during storm events introduces organic arsenic to the subsurface; thus, understanding its adsorption is important. Schreiber emphasized, "All of the arsenic concentrations we are finding at our field site are below the drinking water standards, even below the new standards of 10...New class of antibiotics effective against drug-resistant bacteria discovered in fungi
...c arsenic in to the subsurface during storm events introduces organic arsenic to the subsurface; thus, understanding its adsorption is important. Schreiber emphasized, "All of the arsenic concentrations we are finding at our field site are below the drinking water standards, even below the new standards of 10...Novel protein complex enables survival in hostile environment
...combined activity. "Fsr-N resembles a protein that introduces electrons into the membrane-based energy transduction systems of certain archaea. Such an energy transduction system is also found in E. coli and humans," Mukhopadhyay said. "Fsr-C is similar to the sulfite reductases that are found in certain bacter......premature baby with liquid and then the respirator introduces and extracts the required quantity of liquid at a ...cts part of the perfluorocarbon from the lungs and introduces the next oxygenated dose. The same machine carries out the removal of CO2 from the perfluorocarbon a...Powerful technique for multiplying adult stem cells may aid therapies
... isolates hematopoietic stem cells from a patient, introduces a harmless virus into them that expresses a correct version of the mutated gene, and then re-administers the stem cells back into the patients. While many clinical trials have succeeded, some ended tragically when the virus ended up activating a canc...Nano machine switches between biological and silicon worlds
...d at the specific sequence of bases. Then the team introduces ATP, the phosphate molecule that provides energy within living cells, into the microfluidics channel. This is the fuel for the motor. The motor then pulls the upright DNA strand through it until it reaches the magnetic bead, like a winch lowering a w...Nanopore method could revolutionize genome sequencing
...he DNA and use multiple sequencing machines, which introduces additional sources of error." The study was funded by the National Science Foundation and by the National Human Genome Research Institute at the National Institutes of Health. The NIH funds are from a program launched in 2004 to encourage researc...Gatekeeping: Penn researchers find new way to open ion channels in cell membranes
...without changing the membrane voltage. The finding introduces a new paradigm for understanding the gating of ion channels and lays the conceptual groundwork for designing new drugs to control ion-channel activity in medical intervention. Voltage-gated ion channels are embedded in the cell membranes of most t...Small molecule interactions were central to the origin of life
...cations, and changes in locale. Instead, Shapiro introduces the idea of a "driver" reaction, linked to a free energy source, that helps convert an unorganized mixture into a organized, self-regulated metabolic network. "If we wish a more plausible origin of life, then we must work with the assumption that l...Stormy days ahead for coral reefs
...islodged during extreme weather. The research introduces a new concept ?colony shape factor (CSF) ?to translate the myriad shapes and sizes of coral colonies onto a simple scale that measures their vulnerability to dislodgment. Any severe event, like a cyclone, imposes a threshold that can be scored on th...Coral reefs are increasingly vulnerable to angry oceans
... be dislodged during extreme weather. The study introduces a new concept, "colony shape factor," to translate the myriad shapes and sizes of coral colonies onto a simple scale that measures their vulnerability to being dislodged. Any severe event, like a hurricane, imposes a threshold that can be scored on ...Stanford discovery may help predict when toxoplasma can be deadly
...o genes that produce two proteins that Toxoplasma introduces into the cells of the host it infects. What's more, the researchers showed for the first time that certain changes in either of the proteins - called kinases - ramped up 10,000-fold the damage that Toxoplasma inflicted on the lab mice. "This w...Einstein researchers demonstrate a novel approach to treating AIDS
...r issue of PLoS Medicine. "More broadly, this work introduces a new approach for treating the many viral infections, from hepatitis C to Ebola, in which viral proteins are expressed on the surface of infected cells." The Einstein researchers used a technique called radioimmunotherapy, in which radioisotopes a...Turning green gunk to gold, anti-cancer gold
...ization of an enzyme, cytochrome P450, that always introduces the epoxide in the desired beta configuration. Sherman, who is also the John G. Searle Professor of Medicinal Chemistry in the College of Pharmacy, believes that this approach will allow effective new cryptophycin analogs with low levels of side e...Brown cancer biologists identify major player in cell growth
...The work, published online in Nature Cell Biology, introduces a new pathway that can be manipulated to control cell growth. Since cell growth is a fundamental biological process, the research may shed light on everything from miscarriages to muscular dystrophy. The main application, however, is cancer. Since a ...