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Tag: "interfering" at biology news

BRCA1 causes ovarian cancer through indirect, biochemical route

...ed BRCA1 genes cause ovarian cancer indirectly, by interfering with the biochemical signals one ovarian cell sends to another, according to a team of researchers led by scientists at the USC/Norris Comprehensive Cancer Center and the Keck School of Medicine of the University of Southern California. Their work i...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

...e that inhibited this enzyme specifically, without interfering with the normal regulation of the cell," said Casey. "What we found was a series of 30 structurally related molecules, and we selected the one with the highest potency ?that is cysmethynil." Once the scientists had identified cysmethynil, they worke...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

...sion of these tumors. It has been established that interfering with the function of one gene, called Adenomatous Polyposis Coli (APC) has a profound effect on the cells lining the innermost layer of the colon (called the epithelium) and causes them to lose control over their proliferation leading to tumors. Now...

VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain

...of alcoholism." Other studies have suggested that interfering with Bdnf signaling can alter alcohol consumption. If researchers can identify drugs that may inhibit or activate the function of one of the genes identified in these studies, they may be able to generate new treatments for alcoholism or addiction, ...

Children's taste sensitivity and food choices influenced by taste gene

...at many children do not like bitter taste, thereby interfering with vegetable consumption and potentially limiting intake of important nutrients," comments lead author Julie Mennella, PhD, a developmental psychobiologist. "The recent Nobel Prize award demonstrates the importance of the identification of genes co...

Stopping smallpox in its tracks: A new anti-viral approach

...oach "may serve to turn the tables on the virus by interfering with the very pathways that are required for viral replication and extrusion." This study demonstrates, for the first time, that chemical inhibition of host cell signaling pathways exploited by infectious agents represents a new avenue for developme...

miRNA profiling

...lass of small RNAs, called repeat-associated small interfering RNAs. Because of the importance of zebrafish as a vertebrate model organism, this analysis provides an important starting point for dissecting of function and evolution of small RNAs and their targets. ...

Used in a new way, RNA interference permanently silences key breast cancer gene

... deliver a specifically designed long-acting small interfering RNA (termed a short hairpin RNA, shRNA) for mouse STAT3 into a mouse breast cancer cell line. They chose STAT3 because when activated, it is involved in the formation of multiple types of tumors, including breast cancer. When hijacked by a cancer cel...

Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma

...fied to also smuggle into tumor cells siRNA (short interfering RNA) encased in nano-sized sugar polymers. The siRNA was designed to target a specific growth-promoting gene called EWS-FLI1 that's active only in Ewing's sarcoma tumors. Once inside these cells, the genetic machinery of the tumor cells are effectiv...

Ancient immune defense mechanism is no match for HIV-1

... HIV-1 to elude the cell's natural RNAi defense by interfering with the ability of Dicer to process dsRNAs. "Our results suggest that the dynamic interplay between RNAi and SRS remains physiologically conserved from plants and invertebrates to higher vertebrate animals," explains Dr. Jeang. "Our finding that Ta...

Natural Killers Could Lead to New Hepatitis Treatments

...be possible to manipulate the NKT cell, perhaps by interfering with CXCR6 function, to ameliorate the inflammatory process,?he said. Still unknown, said Littman, is which antigens alert NKTs to infections, as well as the nature of the regulatory machinery of crawling and stopping. The chemical the researchers u...

Pair of cancer genes found to drive both cell migration and division

...s halves to separate, raising the possibility that interfering with them could be helpful in stopping the uncontrolled cell division found in cancers. Mutations in the genes, called PTEN and PI3K, already had been found in over half of all human cancers. "In cancer, you sometimes see cells failing to divide or ...

FDA Approves New Treatment for Chronic Hepatitis B

...de slows the progression of chronic hepatitis B by interfering with viral reproduction. FDA based its approval of Baraclude on the results of three studies in which Baraclude was compared to another anti-viral drug, lamivudine. In all three clinical studies, patients treated with Baraclude showed significant i...

Cancer related gene p53 not regulated as indicated by previous tissue culture research

...fic drugs that unleash the killing power of p53 by interfering with its negative regulators. Our cells are vulnerable to DNA breaks caused by UV light, ionizing radiation, toxic chemicals or other environmental damages. Unless promptly and properly repaired, these DNA breaks can let cell division spiral out of ...

Molecular steps involved in the creation of gene-silencing microRNAs identified

...h, miRNAs appear to work by binding to and somehow interfering with messenger RNA, itself responsible for translating genes into proteins. But how do miRNAs arise? And what can we learn about their biological function from their origins? In a study published last year in Nature, researchers at The Wistar Instit...

Engineered skin offers clues to melanoma development

...xt, Chudnovsky and colleagues investigated whether interfering with either the Rb or p53 pathways could trigger melanoma. They found that in combination with Ras and hTERT, the expression of cyclin-dependent kinase 4 (CDK4),which promotes cell growth and inhibits Rb function, induced invasive melanoma in human t...

Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

...xt, Chudnovsky and colleagues investigated whether interfering with either the Rb or p53 pathways could trigger melanoma. They found that in combination with Ras and hTERT, the expression of cyclin-dependent kinase 4 (CDK4),which promotes cell growth and inhibits Rb function, induced invasive melanoma in human t...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

...xt, Chudnovsky and colleagues investigated whether interfering with either the Rb or p53 pathways could trigger melanoma. They found that in combination with Ras and hTERT, the expression of cyclin-dependent kinase 4 (CDK4),which promotes cell growth and inhibits Rb function, induced invasive melanoma in human t...

Once given 'no respect,' cells' tiny RNAS take driver's seat

...es can be used to make proteins, by binding to and interfering with genes' protein building-instructions. The microRNAs play roles in cell division, cell specialization and cell death in worms and flies and are off-kilter in human cancers, but the Myc protein is the first factor identified that controls the prod...

Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

...sorted to small biological molecules, called short interfering RNA, or siRNA, which derail the process of translating genes into proteins. They work like a dimmer switch, reducing the amount of available gene product, in this case the enzyme BACE1. A modified lentivirus, which has been developed in Verma's lab,...

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