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Tag: "inhibitor" at biology news

In mice, drug protects against diabetes and atherosclerosis

...Research Institute in Princeton, NJ, to develop an inhibitor of the aP2 protein. "There was no traditional m...e as a "rationally designed, potent, and selective inhibitor of aP2" that blocks the protein's ability to bind with fatty acids -- the function that leads to inf...

U-M researchers discover gene switched off in cancer can be turned on

...me cancer cells. By exposing the BRM protein to an inhibitor drug, the researchers were able to turn the gene back on, allowing BRM to be expressed. The researchers found this gene is turned off in about 15 percent of tumors studied, including cells from lung, esophageal, ovarian, bladder, colon and breast can...

Researchers shed light on mechanism of action used by anti-cancer drug

...ancer in adults. It was originally developed as an inhibitor of the oncogene, Raf, which is frequently mutated in numerous cancers, including leukemia. Oncogenes are typically responsible for promoting tumor growth. Previous findings by Grant’s team, reported in the Journal of Biologic Chemistry, showed tha...

Hearts of male and female rainbow trout are different

...sought to determine if sodium cyanide (NaCN) -- an inhibitor of oxidative metabolism ¡V decreases activity of the glycolytic pathway and cardiac performance in both sexes, and if males possess a larger outermost (epicardial) layer of the ventricle vs. the inner endocardium layer. The trout heart is a composite...

Scientists discover rare 'gene-for-gene' interaction that helps bacteria kill their host

...that Photorhabdus produces a special phenoloxidase inhibitor to protect itself against this particular defence. They identified the inhibitor as a small molecule called 1,3-dihydroxy-2-(isopropyl)-5-(2-phenylethenyl)benzene, known as ST for s...

8 plants from South Africa may hold potential for treating high blood pressure

...the researchers examined 16 plants to identify ACE inhibitor activity. The plants were: Amaranthus dubius, a flowering plant also known as spleen amaranth Amaranthus hybridus, commonly known as smooth pigweed or slim amaranth Amaranthus spinosus, also known as spiny amaranth Asystasia gange...

New Brandeis research sheds light on memory by erasing it

...ermine whether the kinase leaves the synapse after inhibitor is applied. This provides a way to directly visualize the forgetting process and complements previous work done in Lisman's laboratory showing that when LTP is induced (as during learning), CaMKII moves into the synapse. ...

Fat screen delivers plant-derived chemical with antidiabetic effects

...hibits fat cells' production. "Harmine inhibits an inhibitor for a net positive effect on fat" that ultimately appears to restore insulin response without some of the side effects attributed to TZDs, Tontonoz said. The findings provide "a second example of a small molecule that both promotes fat cell differ...

Gut research yields new anti-cancer approach

...enter found that medium-to-high doses of PPARgamma inhibitor killed colorectal cancer cell lines. Despite the compound's class name, the anti-cancer effect has nothing to do with the ability of the compounds to inhibit PPARgamma function. Researchers believe that PPARgamma inhibitors instead attack the "skelet...

Glucose triggers brain cell death in rats after hypoglycemic coma

...n death were prevented when the rats were given an inhibitor of NADPH oxidase, indicating a key role for this enzyme. "It is well-established that mitochondria can be a source of oxidative stress," says Swanson. "But in this setting, oxidative stress comes from an entirely different source." He adds that ...

A genetic 'gang of 4' drives spread of breast cancer

... treat advanced colorectal cancer. Celecoxib is an inhibitor of COX2 that is used as an anti-inflammatory, and is being tested in clinical trials against many types of cancer. The researchers also tested whether cetuximab and celecoxib would work effectively in concert to reduce metastasis in mice. "We found...

New protein inhibitor impedes growth of cancerous cells

Researchers have developed a small-molecule inhibitor of a protein that plays key roles in the control of cell division, and they show that the inhibitor can halt the growth of tumors in mice and cancer-derived cells growing in culture. The findings are ...

Finnish scientists discovered a new approach to treat virus-induced lymphomas

... is based on a potent and selective small-molecule inhibitor of the p53–MDM2 interaction, the Nutlin-3a, origin...tigen LANA to both p53 and MDM2, and that the MDM2 inhibitor Nutlin-3a disrupts the p53-MDM2-LANA complex and selectively induces massive apoptosis in PEL cells....

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...ponses of the cell line panel to lapatinib, a duel inhibitor of EGFR and ErbB2 and CI-1040, a MEK enzyme inhibi...ptides to determine whether or not tyrosine kinase inhibitor therapy, combined with radiation therapy, is indeed effective against lung or brain cancer. "It...

Researchers find hepatitis A and hepatitis C attack same protein to block immune defenses

...ng with the production of interferon beta?a potent inhibitor of virus replication. Recent research has shown that hepatitis C generates a protein called NS3/4A that chops up MAVS, interfering with immune signaling and possibly providing the cover the virus needs to survive so long in the liver. Now, Lemon and ...

Inflammation may play role in metastasis of prostate cancer

...ast, cancer metastasis. "Maspin is a very potent inhibitor of metastasis; in a patient with metastasis, cells have found a way to turn off Maspin, which may depend on invasion of the tumor with RANK ligand-producing cells that activate IKKa," said Karin. Malignancies progress through stages. In early, non...

Discovery of an HIV inhibitor in human blood points to new drug class

...NHIBITORY PEPTIDE, or VIRIP, acts as a broad-based inhibitor of HIV-1. Moreover, they showed that a few amino a...ells. That unique underlying mechanism allowed the inhibitor to remain effective against viral strains that are resistant to other antiretroviral drugs, they fou...

Protein therapy may reduce infarct size in heart attack patients

... Phase 1 study evaluating a novel protein kinase C inhibitor that had shown benefit in animal models, but had n.... Animal studies have suggested that KAI-9803, an inhibitor of PKC, may reduce injury in damaged heart muscle cells, but this class of therapies had not previou...

Cholera pathogen reveals how bacteria generate energy to live

...f them might be targeted by novel antibiotics. "An inhibitor or drug would be specific," she said. "You could kill the bacteria without doing anything to the human host." But Barquera believes that the most important benefits of her research could develop in ways that cannot be foreseen: "From the basic sc...

Scientists show drug can counteract muscular dystrophy in mice

.... The scientists tested trichostatin A (TSA), an inhibitor of the enzyme deacetylase, in two mouse models of ...strength of the mice with MD given the deacetylase inhibitor and healthy mice. "This is the first example of using a drug to counteract muscular dystrophy in ...

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