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Tag: "controlling" at biology news

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...egulatory proteins called transcription factors in controlling the expression of genes. Spiegelman and Jiandie Lin, PhD, the paper's lead author and a researcher at Dana-Farber, have previously discovered the PGC-1 co-activator family and several of its biochemical activities. The Dana-Farber researchers made t...

Computers to be used to find blueprint for new influenza drug

... from leaving them should they gain entry, thereby controlling the spread of the infection. Because of similarities between the enzymes used by different viruses and bacteria, a similar approach may also be useful in fighting other diseases such as the South American sleeping sickness, Chagas Disease. ...

Combination therapy boosts effectiveness of telomere-directed cancer cell death

... at the ends of chromosomes that play a key rolein controlling the life span of cells. With every cell division,telomeres get a bit shorter until eventually they become so short thatthe enzymes that copy DNA for cell division no longer work properly andthe cell stops dividing. In a sense, telomeres function as a...

GATA: a graphic alignment tool for comparative sequence analysis

... at the ends of chromosomes that play a key rolein controlling the life span of cells. With every cell division,telomeres get a bit shorter until eventually they become so short thatthe enzymes that copy DNA for cell division no longer work properly andthe cell stops dividing. In a sense, telomeres function as a...

A bacterial genome reveals new targets to combat infectious disease

... relationship may help identify new strategies for controlling diseases caused by filarial nematodes. In a new study published in the freely-available online journal PLoS Biology, Barton Slatko and colleagues present the complete DNA sequence of the Wolbachia pipientis strain within Brugia malayi, a parasitic ne...

Purdue proves concept of using nano-materials for drug discovery

...future drugs to treat diseases will likely work by controlling proteins in cell membranes." Researchers tested the devices with an enzyme that produces a blue color when combined with a liquid that contains molecules small enough to easily pass through the pores. The enzyme, which is a protein, was placed insid...

Scientists identify genetic pathways essential to RNA interference

...n to the technique's potential for gene silencing, controlling levels of RNAi that may underlie some cancers or be used in viral replication may offer further clinical potential. Along with Kim, the study's co-first authors are Harrison Gabel and Ravi Kamath, MD, PhD, of the MGH Department of Molecular Biology....

Researchers trace evolution to relatively simple genetic changes

...e've been able to identify the actual gene that is controlling this trait," the armor-plating on the stickleback, Kingsley said The gene they identified is called Eda, originally named after a human genetic disorder associated with the ectodysplasin pathway, an important part of the embryonic development proces...

Scientists reveal molecular secrets of the malaria parasite

...siteinteract, and perhaps will lead to new ways of controlling the parasitein the vector. * Hall and scientists in Leiden identified evidence ofan unusual method of gene regulation (called post transcriptionalregulation) at the transition between the vertebrate host and themosquito. That motif regulates proteins...

Octopuses occasionally stroll around on two arms, UC Berkeley biologists report

...e've been able to identify the actual gene that is controlling this trait," the armor-plating on the stickleback, Kingsley said The gene they identified is called Eda, originally named after a human genetic disorder associated with the ectodysplasin pathway, an important part of the embryonic development proces...

UCLA scientists transform HIV into cancer-seeking missile

...is approach offers many potential applications for controlling cancer and other diseases." "We may be able to boost immune-system surveillance at tumor sites, identify cancer cells' exact location and kill them before they cause damage," he added. "Beyond cancer, it may be possible to correct acquired and genet...

RNA project to create language for scientists worldwide

... Leontis describes RNA molecules as "the software controlling how the genes are expressed to make proteins." They are unique in being able to store and transmit information as well as process that information. The continuous discovery of new RNA molecules with novel biological functions is beginning to show th...

Unexpressed But Indispensable -- The DNA Sequences That Control Development

...o influence the local topology of the DNA, thereby controlling access to their associated gene. Several clusters also appear in regions without any known genes—the identification of these clusters might lead to the discovery of new developmentally significant genes. While “in silico?discoveries such as this can...

Opposing fat metabolism pathways triggered by a single gene

...tabolism, which interact to form a feedback system controlling the consumption and composition of fats in the nematode. Using RNAi to suppress gene expression, the researchers discovered that when nhr-49 was absent, the lifespan of the nematode was reduced by more than 50%, and the animal displayed numerous gro...

Antibiotic might fight HIV-induced neurological problems

...eople, antiretroviral treatments do a great job of controlling HIV in blood, but most of the drugs don't cross the blood-brain barrier very well," says Christine Zink, D.V.M., Ph.D., professor of comparative medicine at the Johns Hopkins University School of Medicine. "As a result, even though the infection seem...

Wisconsin researchers identify sleep gene

...ystem, Tononi notes. "The key molecular mechanisms controlling the circadian timing of sleep are well understood, but details about the homeostatic mechanism that regulates the amount of sleep have been unclear," he says. In a four-year, round-the-clock search, researchers screened 9,000 mutated fruit flies, ma...

Anti cancer virotherapy well tolerated in first human administration, research finds

...f CVA21 may be of potential therapeutic benefit in controlling the spread of melanoma," Professor Shafren said. CVA21 is one of a small group of naturally occurring rather than genetically modified viruses the Shafren team has been investigating as potential therapies for different hard to treat malignancies in...

Silence the gene, save the cell: RNA interference as promising therapy for ALS

...eurological disease that attacks the motor neurons controlling muscles. Although its victims retain all their mental faculties, they experience gradual paralysis and eventually lose all motor function, becoming unable to speak, swallow or breathe. Known also as Lou Gehrig's disease, from the baseball player who ...

Scientists identify genetic pathways essential to RNA interference

...n to the technique's potential for gene silencing, controlling levels of RNAi that may underlie some cancers or be used in viral replication may offer further clinical potential. Along with Kim, the study's co-first authors are Harrison Gabel and Ravi Kamath, MD, PhD, of the MGH Department of Molecular Biology....

Brain-mapping technique aids understanding of sleep, wakefulness

...le knowledge about the actual biological mechanism controlling sleep," said Dr. Masashi Yanagisawa, professor of molecular genetics at UT Southwestern and senior author of the study. "Eventually my dream is to elucidate all the pathways regulating sleep." Dr. Yanagisawa and his colleagues focused on neurons in ...

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