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Tag: "biomarkers" at biology news

Brain holds clues to bipolar disorder

...the bipolar brain. Such abnormalities are valuable biomarkers for the illness and have the potential to help cli...a illustrating how imaging can be used to identify biomarkers and how these markers can help clinicians determine which patients will respond best to certain trea...

Breakthrough developments in rheumatoid arthritis reported

...n Institute, will be presenting related studies on biomarkers and genetic influences on drug response at the same meeting. Identifying Immune System Mediators About one percent of the US population will develop rheumatoid arthritis, an autoimmune disease that leads to painful joint swelling. Scienti...

Extra-aggressive form of idiopathic pulmonary fibrosis identified

... these results may allow investigators to identify biomarkers of disease progression," said Dr King, who is the Chief of Medicine at San Francisco General Hospital and an internationally renowned expert in research and management of pulmonary fibrosis. The senior author on this paper, Dr Naftali Kaminski, ...

Gene expression patterns predict rapid decline in idiopathic pulmonary fibrosis patients

... these results may allow investigators to identify biomarkers of disease progression and, more importantly, better evaluate the effectiveness of potential therapies," added Talmadge E. King Jr., M.D., chief of medicine at San Francisco General Hospital and an internationally renowned expert in research and mana...

Red flag for repetitive stress injuries identified for first time in humans

...al Science, found that the immune system pumps out biomarkers (different kinds of chemicals) as the body begins to become injured by repetitive motions. These biomarkers warn of an underlying problem. "While not a diagnostic test, because the biomarkers could also in...

RNA splicing factor implicated in ovarian tumor cell growth

...e patient survival, it is critical to identify new biomarkers for early detection." Polypyrimidine tract-binding protein is a key regulator of splicing, Beck said. Defects in pre-messenger RNA splicing have been shown to cause a variety of human diseases. Evidence suggests that altered splicing is associated...

Genetic pathways to curable and incurable forms of pancreatic cancer identified

...pes of finding clues to developing early detection biomarkers and possible treatments to halt the progression of the disease. The work involved activating the pancreatic cancer oncogene called Kras and then selectively mutating tumor-suppressor genes such as p53, p16 and Dpc4 in different combinations. In t...

Indicators for risk of heart disease are higher in passive smokers

...rs, the apparent effects of passive smoking on the biomarkers were about one-third to one-half those for active smoking." The associations with fibrinogen and homocysteine observed in the study translate into an increase in a disease risk of five per cent, although the combined effect due to other processes ...

Mailman School of Public Health researchers report blood DNA can be early predictor of liver cancer

...the first study to prospectively examine potential biomarkers for early detection of liver cancer in high-risk populations, including those with chronic hepatitis B and C virus infections. Since most hepatocellular or liver carcinomas (HCC) are diagnosed at an advanced and usually fatal stage, the developmen...

New study may show how to forestall a fatal, virus-caused immune-system meltdown

...st resemble the flu,?Herzog said. “But if you have biomarkers to go along with viral diagnostic techniques you can tell which virus it is and where you are on the continuum of infection. And if you understand the signaling pathways well enough, you can stimulate or suppress the immune response in the right way ...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...ation for Cancer Research, researchers present new biomarkers ?and techniques for determining biomarkers ?that could determine how an individual might respond to drug or radiation therapy. Molecular pre...

Scientists create dual-modality microbeads to improve identification of disease biomarkers

... liquid such as urine. Viruses, proteins or other biomarkers are captured on the bead surface. After the beads ... Georgia Institute of Technology. "Some of the biomarkers for Alzheimer’s disease have very low concentrations in the blood so you need highly sensitive techn...

'Ancestral eve' was mother of all tooth decay

...acterium, Caufield used DNA fingerprints and other biomarkers that scientists have also employed to trace human evolution back to a single common African ancestor, known as "ancestral Eve." "As humans migrated around the world and evolved into the different races and ethnicities we know today," Caufield sa...

Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese

...er disease. In the HC fed mice, researchers found biomarkers that might predict diabetes, including increased levels of insulin, glucose and insulin-like growth factor-1 (IGF-1). Conversely, the HCR fed group had significantly lower levels of these markers, paralleling the SD group. For example, a standard d...

Proteins may predict lung transplant rejection

...to head it off, she said. The study, "Proteomic biomarkers of chronic lung allograft rejection," was carried ...ely) "Preliminary evidence suggests these biomarkers will be an early sign of lung transplant rejection," the authors wrote. The research is continuing t...

Newly identified biomarker detects and regulates spread of brain tumors

...s. This newfound ability to reliably identify biomarkers for malignant astrocytomas means that physicians will have a new minimally invasive method to track the success of treatments. These biomarkers, singly or in combination, will provide a fingerprint of the disease and be able in the future to better ...

First biomarker for human sleepiness identified in fruit flies

...chers hope to make amylase the first of a panel of biomarkers that will aid diagnosis and treatment of sleep dis...testing," Duntley says. "Simple, easily accessible biomarkers for sleep debt in humans would revolutionize our ability to conduct research on the causes and conse...

Protein 'fingerprint' in spinal fluid could spot Alzheimer's disease

...ew York City have identified a panel of 23 protein biomarkers in cerebrospinal fluid that acts as a neurochemica...thods to hone in on a group of cerebrospinal fluid biomarkers that are specific to autopsy-proven Alzheimer's disease. Those postmortem tests confirmed that the ...

Plague proteome reveals proteins linked to infection

...and Kim Hixson, identified the proteins as “unique biomarkers related specifically to growth condition,?accordin...the same approach is being applied to a search for biomarkers across a wide range of biological systems, from other infectious agents such as Salmonella to soil m...

Major cancer study aims to identify protein markers for early-stage disease

...e and standardize the technologies for identifying biomarkers in the blood -- specific proteins, and the pattern...decorated proteins so that we can identify them as biomarkers in blood samples." Analyzing the complex data produced by mass spectrometry using advanced computin...

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