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Tag: "zebrafish" at medical news

Cocaine Exposure can Alter Neuronal Development in Zebrafish

...BUSM) have shown that prenatal cocaine exposure in zebrafish (which share the majority of the same genes with h...human embryos, altered the neuronal development in zebrafish and acutely changed embryonic expression of genes regulating growth, neurotransmission and circadian...

Fishing for a Speedy Recovery After Chemotherapy or Marrow Transplant

...), suppress blood stem cell formation. Finally, in zebrafish whose marrow was depleted by irradiation, those gi...ity to enhance regrowth of cells, Zon says. The zebrafish is ideal for investigating blood formation, says North. It reproduces quickly and in large number an...

Pediatric Cancer Stem Cell Identified

... genetically engineered zebrafish. Some transgenic zebrafish developed visible tumors by 10 days of age. Thr...netic signature that underlies ERMS progression in zebrafish and human patients. Cancer stem cells make up only a small fraction of the overall number of cells i...

Biologists Trace Cause Of Early Blindness To Tissue Defect

... blindness by middle age. Using a line of mutant zebrafish developed by Rockefeller University’s Jim Hudspeth... and suitable for large-scale genetic experiments, zebrafish make ideal research specimens in Perkins’ eyes because they are model systems, both for treating hum...

The Story Behind the Shape of the Heart

...h Yelon, and colleagues found, by using transgenic zebrafish in which they can watch individual cardiac cells, ...ther cardiac function influences cell shape. Using zebrafish mutants with functional defects, they found that both blood flow and cardiac contractility influence...

Regrowth of Zebrafish's Tail Fin may Offer Clues for Treating Human Injuries

If a zebrafish loses a chunk of its tail fin, it’ll grow back within a week. //Like lizards, newts, and frogs, a zebrafish can replace surprisingly complex body parts. A tail fin, for example, has many different types of ce...

Limb Regeneration Exists Innately In All Vertebrates – Says Researc

...of limbs and included three groups of vertebrates: zebrafish and salamanders, which can regenerate limbs throug... a limb from the experimental embryos. In adult zebrafish and salamanders, they found that blocking Wnt signaling with the inhibitory factors, prevented norma...

Chronic Kidney Disease Related To Mutant Gene

...rching for the causes of nephrotic syndrome. Using zebrafish that lack working copies of plce1, they hope to id...fy its activity,' Hildebrandt explains. 'Using the zebrafish model, we can do high-throughput screening of many possible drug candidates for this form of nephrot...

A New Way to Treat Colon Cancer?

...ing Protein (CTBP) researchers were able to rescue zebrafish from the effects of a mutation in the adenomatous ...PB promotes normal development of the intestine in zebrafish carrying an APC mutation,” says David A. Jones, a University of Utah associate professor of oncologi...

Brain protein expression can be damaged with prolonged alcohol exposure

...l for four weeks. Rabin said the researchers chose zebrafish because they are easy to breed and maintain, their DNA sequences are similar to that of humans and they are sensitive to alcohol concentrations. The concentration of alcohol used is similar to alcohol levels observed in humans, Rabin noted, and is ...

New Studies On Zebrafish Could Aid in Treating Birth Defects

... have described the discovery of a mutation in the zebrafish that are remarkably similar to those observed// in...ibuted to structural birth defects and research on zebrafish gene could help find therapies capable of preventing these structural birth defects. Zebrafish are...

Unmasking Nutrition's Role in Genes and Birth Defects

...esses copper, the researchers identified a gene in zebrafish responsible for copper metabolism, called atp7a. T...shellfish, nuts, chocolate and liver. "Whether a zebrafish embryo has enough copper to develop normally depends not only on the total amount of copper, but on ...

Protein Involved In Embryo Formation Found In Malignant Cells

...y injecting malignant melanoma cells in developing zebrafish embryos. The scientists were able to induce abnor...tage of these similarities by using the developing zebrafish to "detect" tumor-derived chemical signals. In addition, one of the hallmarks of aggressive cancer...

The Little Known Facts of Junk DNA

...nline at Science Express. The researchers used the zebrafish to test mammalian DNA and identify DNA sequences, ... standpoint, the last common ancestor of human and zebrafish lived more than 300 million years ago. But the Hopkins researchers developed the new system, by whic...

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