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Tag: "vivo" at medical news

Hybrid Nanoparticles for Multimodal Medical Imaging

...e nanoparticles as contrast agents for improved in vivo imaging. The Oishei grant, "Developing New Advances in Medical Imaging through Nanotechnology," will be used in part to recruit and support a research professor to provide expertise in ultrasound imaging, as well as postdoctoral fellows and graduat...

Turmeric prevents rheumatoid arthritis: US study

...arthritis. This study also provides the first in vivo documentation of a mechanism of action - how curcumin-containing extracts protect against arthritis. The researchers found that the curcuminoid extract inhibits a transcription factor called NF-KB from being activated in the joint. A transcription ...

Blame Myelin for Many Neuropsychiatric Disorders

...is, his hypotheses can easily be tested through in vivo imaging of the brain to study the breakdown and growth of myelin. That will make it possible to directly test in humans the practical utility of the myelin-centered model of the human brain. Ultimately, it could foster the development of novel trea...

A New Research Demonstrates HIV-1 In Resident Immune Cells Of Human Testis

... which retained the same tissue architecture as in vivo tissue and continued to secrete testosterone, was able to support infection by HIV-1. Virus produced from the testis culture was fully active as collected virus was able to infect permissive cells in culture. The finding that HIV-1 can replicate w...

Echinacea: Cold-Season Cure or Risk?

...een no published information about their effect in vivo – in the human gastrointestinal tract. Research conducted by Jerald C. Foote, assistant professor of food and human nutrition, and graduate student Laura Hill yielded some surprising results and pointed to the need for further research. The researc...

First Potential Treatment for Dengue

...ic metalloproteinases inhibitors. A series of in vivo experiments following the same principle confirmed these hypotheses. A mouse model with blood circulatory system colored blue was injected with supernatant containing these enzymes, on their own or in the presence of their inhibitor. This procedure n...

Glucose Sensor That Controls Glucose Metabolism Identified

...dicating that LXR functions as a glucose sensor in vivo that responds to increasing liver glucose uptake. The ability of the LXRs to respond to glucose and its derivatives was very specific: no effect was seen in other nuclear receptors tested. The current study focused primarily on the role of glucose ...

Researchers Investigate Molecular Basis of Memory

... Sevilla, Spain, who performed the behavior and in vivo recordings. "To assess if the molecular mechanisms that generate LTP also underpin memory formation you need to study a living animal while it is learning." Minichiello and her team combined molecular, electrophysiological and behavioural methods ...

Europeans Developing First-Ever Dengue Fever Vaccine

... metalloproteinase were again supported through in vivo testing in mice. The results uncovered by the European-led international team shed new light on Dengue’s pathological strategy. Researchers now suspect that they have not only come across a defence strategy for Dengue, but for a whole range of haem...

New Hope for Regenerative Medicine

... had some capacity to form tissues in vitro and in vivo but it was questionable if these embryonic stem cells could generate transplantable material that would proliferate and replace tissues in an adult." The researchers took a two-step approach: First they injected uniparental ES cells into wild-type...

New Imaging Technique Tracks Traffic Patterns of White Blood Cells

...r intravital observations of leukocyte behavior in vivo by allowing the near-simultaneous observation of c...es will greatly aid investigations to elucidate in vivo imflammatory cell behavior, and provide a powerful tool for the development of therapeutics for thes...

Common Ingredient in Big Macs and Sodas Can Stabilize Gold Nanoparticles for Medical Use

... biocompatible properties, they can be used for in vivo (inside the bod)) molecular imaging and therapeuti...r therapy. Gold nanoparticles could function as in vivo sensors, photoactive agents for optical imaging, drug carriers, contrast enhancers in computer tomog...

Philadelphia Researchers Found A Novel Way To Fight Several Kind of Cancers

... The technique is the first in the new field of in vivo molecular-genetic imaging that doesn't require transfecting tumors with a "reporter" gene, the scientists say. "The beauty of this is that you don't have to introduce any reporter genes into the tumor because they are already there," says radiolog...

Science Builds Behind Pomegranate Extracts for Health

...kinetic parameters, absorption, metabolism, and ex vivo biological activities of a whole-fruit extract of pomegranate standardized to punicalagins in healthy human volunteers." Writing in the Journal of Agricultural and Food Chemistry, the researchers report that blood levels of the metabolites of punic...

No Carrier Necessary: This Drug Delivers Itself

...rystals that they continue to pursue. Further in vivo studies with HPPH nanocrystals are being conducted by scientists at UB and RPCI, including Pandey and Allan R. Oseroff, M.D., Ph.D., chair of the department of dermatology at RPCI and in UB's School of Medicine and Biomedical Sciences. The UB/RPCI ...

United States Department of Defense Selects Ichor Medical Systems to Develop Biodefense Vaccine

...ch company, is developing products based on the in vivo application of electroporation to enhance intracellular delivery of DNA drugs encoding therapeutic proteins or antigens for vaccines. Ichor's proprietary TriGrid(TM) Delivery System (TDS) is the first and only integrated and fully automated system fo...

A Novel Treatment for KSHV-infected Lymphomas

...that Nutlin-3a has striking anti-tumor activity in vivo in a mouse xenograft model for the PEL. Nutlin-3a treatment resulted in a marked regression of all tumors in the treated animals in two weeks. These results demonstrate that p53 reactivation via Nutlin-3a is an efficient treatment for KSHV-lymphomas ...

Micro-jets for Painless Needle-free Injections

...gher doses. Using insulin as a model drug for in vivo experiments with rats, the research team was able to demonstrate systemic delivery of macromolecules using their novel micro-jet injector. Although it takes a little longer for the drug treatment to reach the bloodstream using this delivery system ...

Deficiency in Vitamin D Increases the Risk of Cancer

... high-dose calcitriol treatment in in vitro and in vivo models. In the laboratory, there appears to be no tumor type that is uniquely sensitive to vitamin D treatment – leukemia, lymphoma, myeloma and solid tumor models are all sensitive, which speaks to the value of vitamin D as a potential therapeutic a...

Myelin Associated With Early Evolution of Huntington's Disease

...led in the very early stages using non-invasive in vivo neuroimaging markers of both myelin breakdown and levels of iron....

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