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Tag: "vivo" at medical news

Gel Offers A More Targeted Approach

...y. However they say the next step is to conduct in vivo studies of the hydrogel system so it can be modified to produce oral pills....

Detecting DNA Damage With In-Vivo Alkaline Comet Assay

...which has resulted in increasing demand for the in vivo Comet assay. In response to this demand, RCC Cytot... assay experiments were run in parallel with an in vivo UDS test on the same hepatocyte suspensions. The results have shown that the in vivo Comet assay is ...

Gene-Nanoparticle Gene Transfer Is Better Than Viral Vector Transfer System

...at a non-viral vector has demonstrated efficacy in vivo at levels comparable to a viral vector," Bharali said. Using a new optical fiber in vivo imaging technique (CellviZio developed by Mauna Kea Technologies of Paris), the UB researchers were ...

New Discovery May Help Treat Infertility

...e combination of the two different methods, the in vivo and in vitro studies, complement each other nicely and provide more precise answers to the role that the estrogen receptor beta plays in ovulation say researchers. Thus by making couples understand the reasons for their infertility, researchers say...

Its Possible To Grow Bone To Replace The Damaged Bone

...mpts to stimulate bone growth within the body ? in vivo ? have had limited success but have proven to be extremely complex, expensive and unreliable. Shastri and his colleagues took a new approach that has proven to be surprisingly simple. They decided to take advantage of the body?s natural wound-heal...

Historic trial for tuberculosis launched together by leading drug companies

...B infection faster than the existing treatment. In vivo preclinical studies have already shown that the drug significantly reduces treatment time by two months. If the trials are successful, the partnership aims to register moxifloxacin for a TB indication and is committed to making it affordable and acce...

Novel Technique For Targeting Small-Cell Lung Cancer

...ne of the more promising conjugates were tested in vivo by fiber-optic spectrofluorimetry and quantitative spectral imaging, on an H69 human SCLC tumor mouse xenograft model. The lead compound showed exceptional tumor/normal tissue ratios, ranging from 9 to 90, and had potential for targeting SCLC overe...

Passive Cigarette Smoking Increases Isoprostane Formation

...ar damage. Isoprostanes, a reliable marker of in vivo oxidation injury, have been shown to increase in a...5) document a significant temporary increase in in vivo oxidation injury due to passive smoke favouring development and/or progression of vascular disease. ...

Exercise Can Strenghten Knee Cartilage

... in moderate, supervised exercise. This in vivo cartilage monitoring study in patients at risk of knee OA who begin exercising indicates that adult human articular cartilage has a potential to adapt to loading change. Moderate exercise may thus be a good treatment not only to improve joint...

Breakthrough In New Vaccine For Malaria

...ility and complexity. The scientists also did in vivo experiments in mice, infecting them with the parasite and then injecting a small amount of the vaccine-produced antibodies. The antibodies significantly cut the number of parasites in the blood of these animals and in some cases wiped them out entir...

New Procedure Reveals the Secrets of the Brain

...ng the utility of their technique in uncovering in vivo functional connectivity maps. Use of the microstimulation/MRI technique in conscious, alert primates holds great promise for determining the causal relationships between activation patterns across distributed neuronal circuits and specific behaviors...

Breast Tumor Metastasis Stimulated by Post Pregnancy Circumstances

... virgin matrix. The group thereafter conducted in vivo studies to confirm the hypothesis that post-lactation involution matrix promotes tumor cell migration, called metastasis.. The alterations in the extra cellular matrix that take place post-pregnancy involution may actually bring about metastasis o...

Discovery Of New Molecule Could Solve Cancer Spread Mystery

...ogression of lethal malignant glioma cells both in vivo as well as in vitro. This study reinforces the concept that successful small molecule kinase inhibitors must display a broad reactivity to effectively attenuate the complex signaling pathways involved in malignant transformation and to thwart to th...

Advance in Program for Development of Non-Intravenous Therapy for Hemophilia

...eatment of hemophilia. Extensive in vitro and in vivo analysis has identified several synthetic lead molecules with promising pharmacological properties. "Using our proprietary technology platform, we continue to make important progress in our collaboration with Baxter, the leader in hemophilia therap...

Broad Spectrum Antibiotic Available for Antibiotic Resistant Bacteria

...by comprehensive global in vitro studies and an in vivo clinical trials programme. The most common adverse events reported in clinical trials with tigecycline were nausea and vomiting. These occurred early in the treatment and were generally mild or moderate in severity. Source : Eurekaert...

Experiments In Outer Space To Determine single Cell Survival

... latency period. TB bacteria can remain dormant in vivo for 30-50 years and then re-activate to cause disease. Presently the state of the dormant bacterium is not understood. Timmins and Brinker are discussing further experiments to validate the model. vvFinally, building the cells into a coating with a...

Muscular Dystrophy Reversed In Lab Mice

...scle function. "The results represent the first in vivo proof of principle for a therapeutic strategy for treatment of myotonic dystrophy by ablating or silencing expression of the toxic RNA molecules,' the authors said. In MD there is a faulty DNA, which is responsible for almost all of the abnormaliti...

Nanotechnology – to detect and treat ovarian cance

...nder development to follow the tissue stiffness in vivo to diagnose cancer. A second area of research involving nanotechnology uses viral particles as templates to fabricate uniform, nanometer imaging probes and drug carriers. The research team is extracting the DNA from viral particles and replacing it...

First Study to Show How Immune Cells 'Speak' to Each Other in Vivo

...l significance of mature immunological synapses in vivo during antiviral immune responses. The findings wi...ow immunological synapses 'speak' to each other in vivo has not been observed prior to this research. Although formal proof of this awaits the development o...

Molecule responsible for age associated macular degeneration identified

...f CEPs found in the eye. The researchers did in vivo animal studies with membranes from chicken eggs and rat eyes and found that CEPs attached to proteins induce angiogenesis. They also found that the protein part of CEP-protein adducts is not important for producing the growth of the blood vessels. Ra...

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