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Genesis of SUPAC

Scale-UP and Post Approval Changes (SUPAC) is an integral part of pharmaceutical product development but till a few years ago, no guidance was available, to assure a smooth scale-up operation. US FDA was the first regulatory body to address this issue. // ..Any pharmaceutical product developed by R&D team has to undergo various stages of scale-up from ‘laboratory-scale’ to ‘pilot-scale’ to ‘pr...

Occupational Exposure To Radiation Causes Chromosome Aberrations

Professor Manoor Prakash Hande and his colleagues from National University of Singapore studied the effect of plutonium exposure and risk of developing Chromosomal aberrations leading to cancer// in Plutonium plant workers. The study is mainly aimed at identifying biomarkers for easy detection and identification of chromosome aberrations. The study is also aimed at finding a link between complex...

Occupational exposurer aises respiratory symptoms

According to a Norwegian study of 1656 subjects over an eleven year period reveals how exposure to dust and fumes in the workplace is linked to a significant increase in respiratory symptoms.// Initially, 2500 subjects from the city of Bergen and its surroundings were enrolled in 1985 and asked about lung symptoms, workplace dust and fume exposure, smoking habits and asthma. ....Then, after 5 ye...

Your Occupation May Protect You From Dementia

Publishing in the September issue of the, researchers from University of South Florida had reported in the latest edition of the Journal of Gerontology: Psychological Sciences that the more nature of mental exercise performed during working may have a role to play in reducing the risk of dementia in later life.// ....Scientists had examined the relationship between complexity of main lifetime occ...

Immune response in Occupational metal fume inhaling workers

Professor Keith Palmer and his team from Southampton General Hospital, studied the inflammatory response in occupational metal fume inhaling workers.// The research work is aimed at studying the environmental risk of developing infections and diseases due to occupational exposure to metal fume. ....Researchers found that the inflammatory response in Metal fume workers to be low compared to the n...

The Hazard of Occupational Asthma

United Kingdom: Many of Britain’s workers frequently report sick due to respiratory problems, and it is estimated that nearly 1500 to 3000 people develop// occupational asthma every year. Prolonged exposure to dust or substances called "respiratory sensitizers" can trigger occupational asthma. ....Alveolitus or 'occupational asthma’ is triggered by constant exposure to dust, which leads to an all...

AIIMS Doctors yet to Get Pay; Pro-Quota Activists Attack UPA Govt

The anti-quota agitators at AIIMS were still awaiting their salaries for the strike period, a day after the Supreme Court directed the Health Ministry to pay them for strike period. // .... ..AIIMS Registrar V P Gupta said the Institute authorities were "awaiting directions" on release of salaries to the anti-quota agitators... .."We are waiting for directions," he said adding that the apex Cou...

Occupational Hazards increase Breast Cancer risk

A recent study revealed that women at different work places were at higher risk for breast cancer. According to it, women who worked or have grown up// on a farm have a risk of breast cancer that is 3 times higher than non-farm workers. ..The study also found out that women working in healthcare and car making were at 4 times higher risk for breast cancer than the national average...This study,...

Transmission of Antibiotic-Resistant Bacteria Linked to Previous ICU Room Occupants

Staying in a room in the intensive care unit previously occupied by a patient with treatment-resistant bacteria may increase the odds of acquiring such bacteria.// ....Two particular microorganisms cause significant illness and death in hospitals: methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), according to background information in the article. Rese...

Occupational Therapy Improves Independence in Stroke Survivors

Occupational therapy significantly reduces the risk of deterioration after stroke, according to a new systematic review. // ....Patients who participated in after-stroke rehabilitative therapy proved better able to perform self-care tasks and were more likely to maintain these abilities, compared to patients who did not undergo occupational therapy, the researchers found. ...."The most important...

Stroke Patients Benefited by Occupational Therapy

Stroke patients are benefited by occupational therapy which helps them recover their ability to take care of themselves and keeping them independent// longer, according to a new scientific review of the best available data. ..Lead author of the study Dr. Lynn Legg of the Glasgow Royal Infirmary in Scotland, said, "The most important finding is that occupational therapy works. Very few interventio...
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