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Tag: "transgenic" at medical news

A new century of Alzheimer's disease research

...e people, AB42 decreases,” he says. Turning to the transgenic mice, the researchers found that as soon as plaque...ys. So the researchers turned again to their tau transgenic mouse, which features a unique on-off “switch”¬ to control the expression of the mutant gene so that...

First Genetically Engineered Maize Resistant to Maize Streak Virus Produced in S. Africa

... maize plants. When the virus infects one of these transgenic maize plants, the mutated protein, which is expres...rus from replicating and killing the plant. The transgenic maize variety has proven consistently resistant to MSV and the trait can be reliably passed on to th...

Insights into Acute Promyelocytic Leukemia

...solutely essential for APL development in PML/RARA transgenic mice. Pharmacological activation of RXR relieved PML/RARA-induced transcriptional repression and triggered APL differentiation only when RXR was in a complex with PML/RARA. In addition, PML/RARA promoted posttranslational modifications of RXR, inc...

New Transgenic Mushrooms Raise Hope for Mass Production of Human Drugs

...r, Inc. have patented the technology of making new transgenic mushrooms, which have increased hope of using mush...stance gene was a marker gene to help sort out the transgenic mushroom cells from the non-transgenic cells. Scientists then cut small pieces off the mushroom's ...

DBT And IAVI Forge Partnership To Develop Next Generation Vaccine Candidates

...its credit. Initiatives have been taken to promote transgenic research in plants with emphasis on pest and disea...and for different States. Necessary guidelines for transgenic plants, recombinant vaccines and drugs have also been evolved. A strong base of indigenous capabilit...

Biotechnology Will Dominate The 21st Century

...mated as 40 per cent. Referring to the approval of transgenic crop Bt cotton and 20 recombinant therapeutic prod...will monitor and control Bio-Safety assessments of transgenic crops. Welcoming the higher production of Bt cotton, Members suggested to improve the quality of lon...

Antibody-based Therapies Effective at Controlling Malaria

...s can be determined using rodent malaria parasites transgenic for P. falciparum antigens in mice and humans. An in vivo mouse model has significant advantage over the use of new world primates, the only other model for human malaria, which are labor-intensive and difficult to reproduce. These novel human reag...

Scientists Develop Method to Track Immune System Enzyme in Live Animals

...his issue, Dr. Casellas and his colleagues created transgenic mice that had a green fluorescent protein derived from jellyfish fused to the AID enzyme. In these transgenic animals, B cells express the tagged enzyme during the immune response. In a second mouse strain, C...

Pediatric Cancer Stem Cell Identified

...a strain of genetically engineered zebrafish. Some transgenic zebrafish developed visible tumors by 10 days of age. Through their model, Dr. Zon and colleagues were able to identify both an ERMS tumor-cell-of-origin and a novel genetic signature that underlies ERMS progression in zebrafish and human patients...

Research may Yield Improved Treatment for Diseased Lungs

...on in molecular biology will enable Chesler to use transgenic mice to explore the physical role of collagen-mediated large-artery stiffening in pulmonary arterial hypertension. She will induce large-artery stiffness in the mice in a process that mimics scleroderma, a disease in which the body produces too much ...

Mouse Model Points to Strategy for Treating Rare Muscle Disease & Kidney Disorders

...pothesis, Dr. Huizing and her colleagues created a transgenic mouse model in which M712T GNE gene mutation was i...loping adult-onset muscle disease as expected, the transgenic mice developed a kidney condition that caused them to die just a few days after birth. When the rese...

DBT And IAVI Forge Partnership To Develop “Next Generation” Vaccine Candidats

...its credit. Initiatives have been taken to promote transgenic research in plants with emphasis on pest and disea...and for different States. Necessary guidelines for transgenic plants, recombinant vaccines and drugs have also been evolved. A strong base of indigenous capabilit...

Researchers Discovers DNA Repair as Key to Huntington's Disease

... Director Elias Zerhouni, M.D. In their study of transgenic mice that carried the human Huntington’s gene, the researchers noted that the repeated tracts of replacement repair segments seem stable until the animals reach about 4 months of age. After that point -- which represents middle age for a mouse -- the...

The Story Behind the Shape of the Heart

...man, Deborah Yelon, and colleagues found, by using transgenic zebrafish in which they can watch individual cardiac cells, that cells change size and shape, enlarging and elongating to form the bulges in the heart tube and eventually the chambers. Since the heart is beating as it develops, they asked whether car...

Fish Intake Linked to Higher IQ in Offspring

...m alternative sources, such as algae extraction or transgenic plant sources. Most extracted fish oils are molecularly distilled and steam deodorised to remove contaminants. According to Frost and Sullivan, the European omega-3 market was worth around €160m (£108m) in 2004, and is expected to grow at rates of ...

Cancer Research May Help Biofuels

...oreign genes into a plant, which creates so-called transgenic plants. Instead, it removes genes from a species, modifies them and then reinserts them. Founded in 1999, the company has primarily worked with agribusiness concerns like Monsanto but in the past few years has begun to more closely examine using it...

Researchers Investigate Gene Linked With Circadian Liver Clock

...vates the elements specifically in liver cells. In transgenic offspring fed with tetracycline-like doxycyline (D... Bmal1 functioned normally. In the absence of Dox, transgenic offspring overexpressed REV-ERBa, and Bmal1 was inactive, effectively turning off the liver clocks. ...

Learning Slows Physical Progression of Alzheimer's Disease: Study

...ase." LaFerla and other colleagues developed the transgenic mice used in this study. These mice, bred to develop the brain lesions associated with Alzheimer's, now are used by scientists worldwide to study the disease. Alzheimer's is a progressive neurodegenerative disorder that affects more than 4.5 millio...

'Hen Factories' To Synthesize Cancer Drugs

...g white. Some of these genetically- engineered transgenic hens produced eggs whose whites contained proteins like the monoclonal antibody, m1r24, used in the treatment of melanoma, while other hens were engineered to produce a type of human interferon that impairs viral replication. These proteins may t...

Crucial Link Between Body Composition and Cancer Risk

...s the risk of cancer. During a study conducted on transgenic mice prone to prostate cancer, Tim R. Nagy, Ph.D.,...consumption, confers cancer risk." Two groups of transgenic mice were divided and one group was placed in cooler environs and another group, at a warmer place. ...

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