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Tag: "transcription" at medical news

Plant Growth Regulated by Both Internal Clock and External Light: Study

...xposed to light. o while the internal clock drives transcription of the genes to produce proteins, external light r.... The PIF 4 and 5 proteins are thought to act as transcription factors that turn on other genes involved in growth. The work is published online in the journal N...

Insights into Acute Promyelocytic Leukemia

... In APL, the fusion protein, always involving the transcription factor RARA, acts as a potent transcriptional repr...chanisms reported with various leukemia-associated transcription factors," conclude Drs. So and Dong. A separate group, led by Dr. Hugues de Th from CNRS/Universit...

Electronic Medical Records can Pay You Within 16 Months

...new charts, filing time, support staff salary, and transcription when done electronically in the third quarter of 2005, versus the cost of those same activities performed manually in the third quarter of 2003. The University of Rochester Medical Center estimated that the new electronic medical records system red...

Research Studies on Molecular Switches of Gene

...tal . The on switch, a protein called CREB, is a transcription factora molecule that binds to a section of DNA ne.... Previously, scientists thought that a particular transcription factor uses the same co-factors to activate all its target genes. The new findings showed that pho...

Computerized Doctors Order Reduce Prescription Errors

... prescription errors. Illegible handwriting and transcription errors are responsible for as much as 61 percent of medication errors in hospitals. A simple mistake such as putting the decimal point in the wrong place can have serious consequences because a patients dosage could be 10 times the recommended amount...

Diabetes Drug Dramatically Boosts Potency of Platinum Chemotherapy

...tos. Both drugs work by activating PPAR-gamma, a transcription factor that functions as a master regulator of fat development in the body, a function discovered in the Spiegelman lab in 1994. Spiegelman and others observed that certain PPAR-gamma-activating compounds, called PPAR-gamma ligands, caused cancer cel...

$5M Gift Will Attack Lou Gehrig's Disease

... that injecting that snippet, called a zinc finger transcription factor, into cells causes more of the growth factor VEGF to be produced and enhances nerve regeneration. Further research on this approach will be made possible by the gift. The research team also hopes to develop another genetic tool, called a si...

Understanding and Treating Congenital Diaphragmatic Hernia

...nd lung development. They describe the role of the transcription factor Fog2: Fog2 is the first gene recognized to be necessary for both primary lung development and primary diaphragm development providing evidence for the hypothesis that diaphragmatic defects may be associated with primary lung defects. They note...

To Remember Or Not - Brain Protein CREB Calls The Shots

...re lost.” CREB (cAMP response element binding), a transcription factor found in the brain, which typically increases the production of other proteins in cells, is believed to be involved in memory formation in various organisms. The scientists hope that their findings, reported in the current issue of Science,...

Scientists Identify Genes Activated During Learning and Memory

...ronal plasticity and learning. CREB and zif268 are transcription factors, binding to a cluster of chemical bases represented in the genetic code as letters. Once bound, they regulate genes that, in turn, dictate the assembly of other proteins that alter a neuron during memory and learning. The Carnegie Mello...

Liver Regeneration Unplugged

...resence of two important proteins. Proteins called transcription factors, which affects the DNA in the cell's nucle...neration is relatively low, but they don't include transcription factors, so we may be closer to being able to stimulate liver regeneration than we thought. We think...

Liver Regeneration may Be Simpler Than Previously Thought

...ins were common to both processes. Proteins called transcription factors, which affect DNA in the cell's nucleus, w...late than the other identified proteins. Since the transcription factors were not present in regenerating livers, it might be easier to stimulate liver regeneration ...

Outsourcing of UK Hospital Records to India Opposed

...l secretaries in India have been raised to prevent transcription work in British hospitals// from being outsourced ...ional Health Service (NHS) have outsourced medical transcription work to India, with more considering the option to cut budgetary deficits. The moves have prompted a...

A Novel Treatment for KSHV-infected Lymphomas

...l of Clinical Investigation. TP53 gene encodes a transcription factor (p53) that plays a central role in protecting cells from tumor development by inducing cell-cycle arrest or apoptosis via a complex signal transduction network referred to as the p53 pathway. TP53 gene is mutated or deleted in 50% of all malig...

Major Gene Study Uncovers Secrets of Leukemia

...ing to Downing. These genes encode proteins called transcription factors, which orchestrate the expression of a large number of other genes involved in B cell development. Together these genes coordinate the complex changes needed to induce progenitor cells to differentiate into B lymphocytes. In ALL, the leukemic...

Researchers Discover Gene Essencial to Cerebellum Formation

...lar switch." The researchers hypothesized that a transcription factor, whose function is well known in the pancreas and which appears to play a role in the nervous system, is also involved in the development of the cerebellum. In order to test their idea, and characterize the new mechanism of cell differentation...

Discovery of Cell Pathway may Help Colon Cancer Patients

...ncers. STAT3 (signal transducer and activator of transcription 3) is the newest discovery and is a target regulated by PRPRT (receptor protein tyrosine phosphatase T), already identified to be mutated in these cancers. "The role of protein tyrosine phosphatase in cancer is still an under-explored area," says Zh...

Researchers Identify Cell Pathway in Colon Cancer

...entified STAT3 {signal transducer and activator of transcription 3}, as a target regulated by PTPRT {Receptor Protein tyrosine phosphatase T}, which was previously identified to be mutated in colon, lung and stomach cancer patients. "The role of protein tyrosine phosphatase in cancer is still an under-explored ...

'Gateway' Gene Discovered for Brain Cancer

...rtant candidate for antitumor therapeutics.' While transcription factors are not generally considered useful targets for anti-cancer drugs, there are multiple ways that Olig2 could be inhibited, as well as ways to target other components of the regulatory pathway by which it exerts its influence on tumor growth, w...

A New Treatment Discovered For Acute Lymphoblastic Leukemia

...e been silenced due to a process that affects gene transcription and known as metilation. The WNT pathway activated in an ongoing manner gives rise to the expression of specific genes whose function is to activate the growth of tumour cells. Administration of New Medicinal Drugs The study has shown, with in ...

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