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Tag: "toxicity" at medical news

A new century of Alzheimer's disease research

...ormally.” Dr. Lewis says the studies suggest that toxicity to neurons caused by tau begins before tangles develop. “If so, we may be able to repair that process so that the neuron can rebound,” she says. Their achievement was reported in 2005 in Science. “These tau findings changed our ideas about what th...

Gene Therapy Eradicates Pancreatic Cancer in Mice

...-BikDD combination. "All cancer drugs have some toxicity and so cause side effects, which affects the dose ...ISA-BikDD produces virtually no systemically acute toxicity or acute pancreatitis," the authors report. Dr. Abbruzzese says that the phase I clinical trial w...

New Cancer Therapy in Clinical Trial

...eing used in clinical trials. Potency and lack of toxicity to normal tissues make activation of TNF-a-related apoptosis-inducing ligand (TRAIL) death receptor signaling an attractive and exciting target for cancer therapy, and it is currently being tested in clinical trials. However, most cancer cells have...

Tumor Painting to Fight Against Cancer

...te. Olson and his team are preparing the necessary toxicity studies before seeking approval from the Food and Drug Administration to begin clinical trials. Chlorotoxin:Cy5.5 could be used in operating rooms in as little as 18 months. All clinical studies will have consenting adult participants.Olson and his...

Right Foods Could Improve Drug Effectiveness, Lower Drug Costs

...ts too, the authors add. For example, the major toxicity associated with lapatinib is diarrhea, probably caused by unabsorbed drug. So taking a lower dose with food should "reduce the amount of unabsorbed drug, and therefore theoretically also reduce the frequency and severity of diarrhea." But the auth...

US FDA may Be Asked to Monitor Toxic Levels of Cigarettes

...eports on tobacco, said it could help minimize the toxicity of cigarettes. New products would need FDA approval before they could be sold, according to the legislation. The bill also would authorize the FDA to set national standards for tobacco products to control how they are made, as well as force the disc...

Value Meal Would Lower Drug Costs

...he authors add, may have other benefits. The major toxicity associated with lapatinib is diarrhea, probably caused by unabsorbed drug. So taking a lower dose with food should "reduce the amount of unabsorbed drug, and therefore theoretically also reduce the frequency and severity of diarrhea." Patients shou...

Interactions Between Food and Drugs Could Lower Drug Costs

...he authors add, may have other benefits. The major toxicity associated with lapatinib is diarrhea, probably caused by unabsorbed drug. So taking a lower dose with food should "reduce the amount of unabsorbed drug, and therefore theoretically also reduce the frequency and severity of diarrhea." Patients shou...

Bayer and Onyx Submit Supplemental New Drug Application for Nexavar to Treat Liver Cancer

...may fulfill a serious unmet need with a manageable toxicity profile." HCC, the most common form of liver cancer, is responsible for about 90 percent of the primary liver cancers in adults. It is the fifth most common cancer in the world and the third leading cause of cancer-related deaths globally. Over 600...

Children Using Slide in Playground Treated for Exposure to Poisoning

...e created lead deposits could be another source of toxicity for children, it was then warned. Soil often is contaminated by airborne lead particles that drop to the ground and become "a persistent, hard to remove component of the dust matrix." Playground equipment is another possible source of lead contamin...

Inherited Genes Linked to Toxicity of Leukemia Therapy

...ted into routine clinical care, we should see less toxicity among children being treated for ALL." Relling is ...chemotherapy drugs were linked to gastrointestinal toxicity and infection, respectively. In the consolidation phase, when drugs called antifolates were the main...

US Professors Develop Fusion Protein to Fight Cancer

...xplains, 'So you can see it would cause a lot less toxicity and it should really be a lot more effective.' The research began with breast cancer and expanded to include other types of solid tumors. Although the fusion protein is helpful in treating many types of cancers, researchers say it works best again...

DNA-damage Test Could Aid Drug Development

...cessful drugs, promising drug candidates must pass toxicity tests before entering clinical trials. Researchers...ell culture test for assessing a compounds genetic toxicity that may prove dramatically cheaper than existing animal tests. This assay would allow genetic toxic...

Gilead's AIDS Drug Awaits Patent in India

...ner drug across Europe for HIV/AIDS due to its low toxicity and resistance levels observed in patients. The tablet-a-day dosage of the drug also helps in better regimen and compliance among the HIV/AIDS patients taking it. Alton also pointed out that he expects generic versions of Gilead's anti-retroviral...

Pazopanib Shows Positive in Advanced Renal Carcinoma, Ovarian Cancer and Soft Tissue Sarcoma

...le complete remissions observed in 7% of patients, toxicity has limited its widespread use. Lower dose cytokine therapies have not shown the same magnitude of response and are also limited by their toxicity. Recently, several anti-angiogenesis drugs, including sunitinib, sorafenib and bevacizumab have demonst...

Amrubicin Shows Encouraging Results for Small Cell Lung Cancer Treatment

... Thirty patients in the trial were evaluable for toxicity and safety, 19 for Amrubicin and 11 for topotecan. The most common . grade 3 adverse events were hematological and were generally equal between the two arms. Cardiac adverse events were limited to tachycardia ( "These results are extremely encouragi...

Breast Cancer Drug Curbs Heart Disease.

...le cells might protect the heart against potential toxicity associated with trastuzumab, Spector added. More broadly, Spector said that these findings of how lapatinib bestows cardiovascular protection during times of stress whether from chemotherapy or heart muscle cells deprived of oxygen during a heart ...

Drugs may Help Turn on Gene Switched Off in Cancer

... who have a high likelihood of response. Their low toxicity means the patient can be treated for long periods of time, which is unlike older and more traditional chemotherapy agents. Even if these new targeted therapies dont cure the cancer, we can at least have long-term survival, he adds....

Researchers Discovers DNA Repair as Key to Huntington's Disease

...acts -- an inherited characteristic -- also caused toxicity in cells that cannot expand, such as nerve cells. The result is that cell death acceleration is directly proportional to the additional repeated lengths. In a further step, the team eliminated a key enzyme (OGG1) related to DNA repair for oxidative...

PFOA and PFOS Detected in Newborns

...ese compounds could cause tumors and developmental toxicity in laboratory animals at doses much higher than those observed in the Hopkins study. The analysis conducted in Baltimore, Md., detected PFOS in 99 percent of the infant samples examined and PFOA in 100 percent of those examined. The results are publ...

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(Date:10/25/2014)... Mesothelioma researchers are reporting extended survival in ... after his combination drug therapy became too toxic. ... posted on the Surviving Mesothelioma website. , A ... Japan suggests that “maintenance therapy” with pemetrexed may be ... tolerate higher doses of cisplatin. , “Although the ...
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(Date:10/22/2014)... At a time when the national ... athletes at all levels, the UPMC Sports Medicine ... discussion where two powerful messages are lost: Concussions can ... in full recoveries every day. , In striving to ... and research, UPMC and the Concussion Program are unveiling ...
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