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Tag: "telomere" at medical news

Dotted All Over? - Count Yourself Lucky

... Bataille's team looked at their relationship with telomere length, a good biological indicator of an individu...is was estimated by looking at the average rate of telomere length loss per year. It was concluded that people with a lot of moles appeared to have longer te...

New Genetic Biomarkers Could Predict Coronary Heart Disease

...abetics and Type 2 diabetics which have shown that telomere shortening is greater as a person progresses from ...ammation which could be the one of the reasons for telomere shortening and so an early indication of their telomeres starting to shorten could indicate the onse...

Salk Scientists - Links Between Cancer and Aging

...position, saying, 'These results indicate that the telomere dysfunction in Werner Syndrome cells is a major ca... and we show here a direct relation between aging, telomere loss, and cancer occurrence,' he says. 'I predict that cancer in older people has precisely the same...

Got a Short Telomere-Watch Your Heart

...und a new predictive marker for heart disease, the telomere or strand of DNA found at the ends of the chromoso...group 45 to 64. A study into the length of their telomere (sampled from white blood cells) found that a shorter length was associated with a higher risk of co...

Osteoarthritis May be Sign of Faster “Biological Ageing

...nsurprisingly, the findings showed that white cell telomere lengths were associated with chronological age. Th...among the 160 people with hand osteoarthritis, the telomere length was significantly shorter than among those without the disease, even after taking account of ...

Telomere Plays an Important Role in Ageing

...said that there existed a seven-year difference in telomere loss between people of the same age, same body mass index, same smoking status, same exercise status who happen to be in a manual job or non-manual job, which roughly divides the social classes. He said that psychological stress play an important rol...

Switching Off Protein Could Play Key Role In Success Of Radiation Therapy For Cancer

... we will continue to study how Rad9 influences the telomere structure," Pandita said. "We speculate that witho...man HB, Pandita TK. Mammalian Rad9 plays a role in telomere stability, S- and G2-phase specific cell survival and homologous recombinational repair. Molecular a...

Inactivation of Rad9 in Tumor Cells Would Be Advantageous In Cancer Therapy

...ion. Rad9 proteins interact with proteins called telomere binding proteins. During the experiment if Rad9 in human cells were inactivated it resulted in damaging the chromosomes and caused end-to-end fusion at telomeres. This disrupted the cell cycle and caused cell death. Because radiation treatments inc...

Link between Old Cells and Ageing probed

... important indicator for replicative senescence is telomere dysfunction that stops the division of cells. Infact, scientists did the hair splitting task of counting the cells with bio markers. Their finding revealed that the number of senescent cells increased with advancing age, with cells present in 5 yr ol...

Telomerase Vital In Maintaining Ability of Stem Cell to Multiply

...e genetic basis gets obscured due to the inherited telomere length and not the gene. "If you were to search for the genetic mutation behind this mouse's disease, you wouldn't find it -- there isn't one," says Greider. "These mice develop disease only because their telomeres are short, and having telomerase do...

Chromosome Ends Trigger DNA Damage Response For Telomere Protection

...stability and the DNA damage machinery. An exposed telomere could readily be taken for a break and recognized as damage, and thus, have to be distinguished from DNA breaks that initiate a DNA damage response. To prevent the cell's DNA repair machinery from confusing telomeres with broken strands of DNA that ...

Gene That Might Be Responsible For Aging

...to daughters) was strongly correlated with similar telomere length between parents and children. Results also confirm telomere length is longer in women than in men. Previous studies show the relative length of telomeres is a...

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