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Tag: "targets" at medical news

HIV Spread May Be Arrested By A New Compound

... All along, the drugs intended for HIV infection targets the virus replication. But this compound appears to work differently and counters the mutating capability of HIV virus. This team plans to go further deep into this research focusing on the molecular mechanisms of 2-5AN6B and the remedial measures fo...

Scientists Identify Pancreatic Cancer Stem Cells

...proach might be to design a drug that specifically targets pancreatic cancer stem cells without interfering with normal stem cell function.” While such a drug has not been developed, ongoing research suggests it is possible to do so, she added. The study also advances the emerging notion that stem cells...

New Guidelines for Diagnosis of Venous Thromboembolism

...f Internal Medicine. The new diagnosis guideline targets primary care physicians who are most likely to have frontline contact with patients who have not yet been diagnosed. The guideline aims to present evidence-based recommendations for diagnosis of lower extremity DVT and pulmonary embolism. "These ne...

UCLA Find Yields Further Insight into Causes of Parkinson’s Diseas

...nes in the fly, they may represent new therapeutic targets for PD in humans." The researchers examined the results not only from a genetic standpoint but from a behavioral standpoint as well. To measure the progression of Parkinson's disease in the fly, they designed a small series of rotating glass cylind...

Mixed HIV Coreceptor Use Associated With Lower CD4 Count

...s CCR5 and CXCR4. Usually, these receptors are the targets for substances that activate white blood cells in response to inflammation. HIV that can use CCR5 tends to predominate early in infection while the presence of virus that can use CXCR4, known as syncitium-inducing virus, has been linked with an incre...

Potential for Adult Stem Cells to Repair Hearts Damaged Investigated

...entify Ischemic but viable regions of the heart as targets for cell delivery. The researchers then use a special investigational catheter that functions like a "global positioning system" to precisely deliver CD34+ cells, or placebo, into the areas of the heart that have been identified as having poor blood ...

A Novel Technique Nudges Genes Into Activity

... researchers have the ingrained idea that RNA only targets other RNA – such as what occurs when messenger RNA is targeted during RNA interference. "That’s what everyone is familiar with," he said. "But the idea of RNA being used as a sort of nucleic acid modulator of chromosomes, at the level of the chromoso...

Drug Strategy Makes Cancer Genes Get Lost in Translation

... now report the discovery of a small molecule that targets such weak mRNA, preferentially interrupting its tr...d, noting that the strategy is "unusual in that it targets a protein-protein interaction, which has not typically been considered a good drug target." In add...

Immune System Gears Up by Specific Enzymes

...anized, effective immune system attack on specific targets is thrown into high gear when either of two specific enzymes chop a protein called LAG-3 off the immune cells leading that battle, according to investigators at St. Jude Children's Research Hospital. These cells, called T lymphocytes, are key to t...

Additional Research Imperative on Lung Cancer in Women

...ast, mainly due to smoking, women seem to be equal targets due to increase in women smokers. In 2000, lung cancer deaths among women went up eight times as compared to the figures in 1960. New research into the science of lung cancers has indicated that women may be suffering greater risk and may be more ...

Estrogen Linked to Immune Surveillance in Breast Cancer

...tually help drug designers develop new tests – and targets – for breast cancer therapy. The research team included collaborators from the University of Wisconsin at Madison. Source: Bio-Bio Technoogy SRI...

Web-Based Genomics Tool Designed to Help Predict Disease Susceptibility

...elated to disease susceptibility, progression, and targets for therapeutic interventions," states David A. Schwartz, M.D. director of the National Institute of Environmental Health Sciences (NIEHS), which funded the work along with the NCI. Source: Bio-Bio Technology SR...

VBI Provides Potential Targets to Diabetes Therapeutics

...uld in time help researchers to identify potential targets for docking inhibitors that will slow down, but not fully eliminate, the body's overproduction of glucose. The study investigates ways to control the activity of phosphoenolpyruvate carboxykinase – a key enzyme involved in the metabolic pathway use...

Stem Cells Passed From Mother to Child Live On and Make Insulin

...cells and no evidence that the maternal cells were targets of an immune response from the child's immune system. Instead, the researchers found a small number of female islet beta cells in male pancreatic tissue (procured from autopsies) that produced insulin. Microchimerism is the term used when an indiv...

Scientists Unravel Superbug That Kills in 24 Hours

...ge and help the infection spread. "We now have targets to go for."Source: Bio - Bio Technology...

Understanding Autoimmune Disease

...autoimmunity. But the list of the genes that Foxp3 targets provides an initial map of the circuitry of these cells, which is important for understanding how they control a healthy immune response. "Autoimmune diseases take a tremendous toll on human health, but on a strictly molecular level, autoimmunity i...

Researchers Explore the Effect of Engineered Immune Cells on HIV

...f Proceedings of the National Academy of Sciences, targets the human B cells only. After two years of experimentation, the team has been able to demonstrate that they can specifically target human B cells in mice. "Possibly the most important implication of the work is that gene therapy could now be carrie...

Clues to the Cause of Difficulty With Swallowing

...iatric asthma. Their research may lead to new drug targets for EE, which appears to be allergy-driven in some...n the esophagus, and could provide new therapeutic targets for EE. Their data suggests that increased expression of the molecules TGF-beta 1, phospohrylated-...

Selective Marker Found to Indicate Aggressive Form of Breast Cancer

... Basal epithelial tumors lack important molecular targets such as the estrogen receptor, progesterone receptor and Her2. This not only makes positive diagnosis difficult, say researchers, but also eliminates several important lines of therapy, such as tamoxifen or Herceptin, that work well for other breast ...

Selective Marker Found to Indicate Aggressive Form of Breast Cancer

... Basal epithelial tumors lack important molecular targets such as the estrogen receptor, progesterone receptor and Her2. This not only makes positive diagnosis difficult, say researchers, but also eliminates several important lines of therapy, such as tamoxifen or Herceptin, that work well for other breast ...

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