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Tag: "suppressor" at medical news

Early delivery can prevent cancer

...influence a gene called P53 that produces a tumour suppressor protein. The same is thought to happen in people. In young women, whose breast tissue is still developing, this appears to have life-long effects. The effect is most marked in women who give birth before they are 20, said Professor O'Malley. The rese...

Tumour marker for melanoma found

...2 is involved in one of the pathways of the tumour suppressor gene called p53, which plays a role in many other cancers. However, it is not clear why high levels are linked to a good outcome in melanoma. But its role as a molecular marker may well help doctors to target and refine therapies to the individual pa...

Malignant Mesothelioma – A New Genetic Revelatio

...an unusual molecular pathology with loss of tumour suppressor genes being the predominant pattern of lesions, es...nes, rather than the more common p53 and Rb tumour suppressor genes. In a previous report from earlier this month from the UC Davis Department of Public Health ...

Malignant Mesothelioma – A New Genetic Revelation

...an unusual molecular pathology with loss of tumour suppressor genes being the predominant pattern of lesions, es...nes, rather than the more common p53 and Rb tumour suppressor genes. In a previous report from earlier this month from the UC Davis Department of Public Health ...

Turmeric Found To Slow Down Melanoma Growth

... the studies, we conclude the curcumin is a potent suppressor of cell viability and inducer of apoptosis in melanoma cell lines and future investigation to determine the effects of curcumin in animal models of melanoma and clinical trials would be helpful. Links: http://www.medindia.com /alternativemedici...

Gene causes moles to become cancerous

...ncer cells to grow in melanoma. Id1 blocks a tumor suppressor gene that ordinarily keeps precancerous moles from...mutations to occur in the cancer cells, making the suppressor gene damaged beyond repair. As the cancer grows, researchers reason, Id1 levels decrease because it ...

Moles become cancerous due to genes

...ncer cells to grow in melanoma. Id1 blocks a tumor suppressor gene that ordinarily keeps precancerous moles from...mutations to occur in the cancer cells, making the suppressor gene damaged beyond repair. As the cancer grows, researchers reason, Id1 levels decrease because it ...

Malignant virus in polio vaccine combined to Cancer

...m SV40 have a powerful effect in turning off tumor suppressor genes in humans. Gazdar and the other researchers said that the recent SV40 discoveries also could help lead to effective cancer treatment, by using SV40 as a target for therapies. ``A vaccine targeting SV40 in mesothelioma is now being developed,''...

Researchers Identify Sipa 1 Gene, Responsible For Cancer Metastasis

...gous to human 11q12-13, harbors a known metastasis suppressor gene Brms1. However, this gene has no obvious polymorphisms that influence metastasis. Authors used a multiple cross mapping strategy that uses the shared haplotypes in different inbred strains of mice to reduce the number of candidate genes. This ...

Colgate To Develop Anti-Cancer Toothpastes And Mouthwashes

...234, a mouthwash designed to deliver the p53 tumor suppressor for the prevention of a pre-cancerous condition called Leukoplakia as well as oral cancer. David G. Nance, Chief Executive Officer of Introgen was understandably pleased with the lucrative agreement. We believe that repair of damaged cells and safe...

Drug Xolair for Severe Asthma

...be monitored. Anti-asthma drugs acts as an immune suppressor by which it reduces the immune system to produce less number of immune cells against the allergen, which causes an increased number of Immunoglobulin E (IgE). The trial showing the efficacy of the drug Xolair was tested in 4,300 patients with sever...

Cervical Cancer Can Now Be Better Handled With Gene Silencing Therapy

...ical cancer patients. Certain genes called tumor suppressor genes are responsible for preventing the occurrenc...way to combat tumor is to either turn on the tumor suppressor genes or turn off the tumor promoting genes. Cervical cancer is the leading cause of cancer death ...

Chronic Myelogenous Leukemia (CML) Has An Answer Now!

... phosphatase PP2A. PP2A acts otherwise as a tumour suppressor in the blast crisis, applying the brakes to growth signals stuck in the β€œon” position. When PP2A isn't working properly, cancer cells grow uncontrolled. Earlier studies by Perrotti showed forskolin could restore PP2A function. In the current study, ...

Gene responsible for developing prostate cancer identified

...esponsible for suppressing the activity of Tumor// suppressor protein. Tumor suppressor protein is responsible for maintaining the integrity of cell and prevents the cell from developing t...

Link Between Hepatitis C And Liver Cancer Unraveled By Scientists

...eplicons have enabled researchers identify a tumor suppressor protein, named NS5B. This protein has been found to play an important role in breakdown of the retinoblastoma gene by attaching to it. This molecular mechanism is very similar to the way HPV causes cancer growth. The study has proved to be very val...

Little Known DNA Repair Enzyme May Be A Tumor Suppressor Gene

...t of chromosome 6 which is home for multiple tumor suppressor genes and a slew of human cancers, including a number of leukemias and lymphomas. This segment is associated with chromosomal instabilities in this particular region of chromosome 6. "Although it requires further investigation, we believe that mutat...

Tumor Suppressor p53's Contradictory Regulatory System

...PLoS Biology examines the role played by the tumor suppressor protein called p53. It has been found that any mutations of p53 play a key role in the development of many human cancers. //This particular study was carried out by Min Hu, Yigong Shi and colleagues. To provide a bit of background, when there a cel...

Methyl-DNA binding Proteins To Fight Cancer

...NA methylated binding) inhibits the work of cancer suppressor genes. However, using the same properties of the p...o make chimeric Kaiso work only to activate cancer suppressor genes, not the other methylated DNA sequences. This is what we are working at in the Bioengineering ...

Unusual Tumor-Suppressor Gene Switches Off in Lung Cancer

...d J. Solove Research Institute, have found a tumor suppressor gene that could be of vital significance in the development of head and neck cancers as well as lung cancer. //Their study shows that activating this particular gene could slow up the development of the aforementioned cancers. The gene, called TCF21...

Mouse Models To Determine The Cause Of Aggressive Leukemia

...pital it was found that mutation and loss of tumor suppressor gene resulted in aggressive leukemias.// Researche...d Bcr-Abl and the loss of both copies of the tumor suppressor gene Arf in bone marrow cells triggers an aggressive form of ALL. Loss or inactivation of both Arf g...

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