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Tag: "sirolimus" at medical news

Value Meal Would Lower Drug Costs

... study, a phase I trial of the combination of oral sirolimus (rapamycin) taken with grapefruit juice, which contains substances that delay the breakdown of many drugs. Dozens, perhaps hundreds, of drugs ought to be studied in this way, the authors said. "If we understood the relationship between, say, grapef...

Interactions Between Food and Drugs Could Lower Drug Costs

... study, a phase I trial of the combination of oral sirolimus (rapamycin) taken with grapefruit juice, which contains substances that delay the breakdown of many drugs. Dozens, perhaps hundreds, of drugs ought to be studied in this way, the authors said. "If we understood the relationship between, say, grape...

ENDEAVOR III Trial Reports Key Findings on New-generation Stent

...h zotarolimus, a medication that, like the Cyphers sirolimus coating, reduces renarrowing of the artery by preventing the growth of scar tissue inside the stent. Initial data showed that procedural success was higher with the new Endeavor stent, which is more flexible and is considered easier to implant than ...

Mayo Clinic Study Finds Heart Transplant Patients Benefit from New Approach to Immunosuppression

...ing stable patients from calcineurin inhibitors to sirolimus showed consistent improvement of kidney function. ...tion. A second study found gradual transition to sirolimus in 29 patients also greatly impaired the development of the proliferative changes found in transplan...

Genetic 'Roadmap' Charts Links Between Drugs and Human Disease

...dentified the FDA-approved immunosuppressant drug, sirolimus (also known as 'rapamycin'), as a therapeutic candidate for overcoming drug resistance in a form of human leukemia. These findings, as well as those for gedunin, are described in Science and in separate Cancer Cell publications. 'Although this firs...

Effectiveness Of Drug-Releasing Coronary Stents

...tiveness of the coronary stents coated with either sirolimus or paclitaxel. Drug-releasing stents are known to be more effective in easing the examination of the blood vessels in a procedure called as angiography. // Such stents also improve the prognosis or the outcome of procedures like angioplasty, when a ...

Stents That Release Medication To Check Artery Narrowing

.... These stents (which release medications, such as sirolimus and paclitaxel) have been shown to safely reduce clinical and angiographic restenosis (narrowing again of the artery after treatment) compared with bare metal stents. Enrollment in the trials for these stents, however, was restricted to relatively si...

Drug-Coated Stent

... rate of the artery re-closing with the use of the sirolimus stent was reduced from 21 percent to 8.5 percent. Researchers say, "In this randomized clinical trial involving patients with complex coronary lesions, the use of a sirolimus-eluting stent had a consistent treatment effect." Both future blockages an...

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