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Tag: "silencing" at medical news

Human immunity system can battle HIV.

... in a novel HIV therapy. The process is called RNA silencing and is often a common phenomenon in plants and animals, only it was not known for humans. The process, which works by RNA silencing, can ultimately destroy the RNA of the virus. The scientists of National Institute of Allergy and Infectious Diseases...

Possibility Of Treatment For Permanent Hearing Loss

.... RNAi: RNA interference is a technique of gene silencing that is used to study the effect of absence of a gene, by causing disruption to its expression, on an animal or a plant....

Controlled Gene Expressions Can Cure Many Diseases

... a new technique to control genetic expressions by silencing some expressions of the gene.// This technique is ...tly, the researchers also employed RNA itself as a silencing agent. The researchers designed their RNA to match up with and target specific genes. So far, the ...

Identified Protein To Inhibit Cell Migration

...n RNAi: RNA interference is a technique of gene silencing that is used to study the effect of absence of a gene, by causing disruption to its expression, on an animal or a plant....

New Gene Silencing Mechanism To Prevent Cancer

... a global challenge for centuries. They hope that silencing segments of the genes (heterochromatin), which are... it’s functioning. Understanding the role of gene silencing might thus pave a way to use it as a possible therapy for cancers and other related diseases, which ...

Cervical Cancer Can Now Be Better Handled With Gene Silencing Therapy

... of these genes in cancer cells. Furthermore, gene silencing was found to enhance the effect of chemotherapy by up to four times. One main advantage of this approach is that the normal cells remain unaffected during manipulation, as the main target is the viral gene. The researchers hope to exploit this form...

Australian Scientists 'Silence' Cancer Gene

...Lead researcher Nigel McMillan said that such gene silencing treatments are about three years away from becoming the norm. Dr Ian Frazer, whose team developed the cervical cancer vaccine hailed the achievement of Dr McMillan's team as 'a significant step towards developing gene therapy for cervical cancer.' Th...

Rolling Stones Guitarist Wants Chemotherapy

...) Medindia Related Articles: Furthermore, gene silencing was found to enhance the effect of chemotherapy by up to four times. One main advantage of this approach is that the normal ... www.medindia.net/news/ view_news_main.asp?t=gn&x=5763 Reference: Journal of Antimicrobial Chemotherapy ... Gossypol h...

Unusual Tumor-Suppressor Gene Switches Off in Lung Cancer

...s of the body. Therefore, researchers suggest that silencing the TCF21 gene can help in the cancer spreading to other parts of the body. “The fact that this gene is silenced in many cancer types strongly suggests that it plays an important role in cancer development,” said lead investigator Christoph Plass, a ...

Novel method conceived, to achieve genome-wide gene silencing.

... dormant state. This trait of genes, called gene silencing is crucial to an organism’s health. Gene silencing offers a protective cover for the genome from viruses, and even cancer, and is a big step towards ma...

Researchers Purify Protein That Could Regulate Male Hormones

...ed that consistent with reversing a marker of gene silencing (H3K9 methylation), the protein functions as a co-activator – in this case, a co-activator for the androgen receptor target genes. Using human tissue cultures, including prostate cells, Zhang and his colleagues found that over-expression of JHDM2A ...

Muscular Dystrophy Reversed In Lab Mice

...for treatment of myotonic dystrophy by ablating or silencing expression of the toxic RNA molecules,' the authors said. In MD there is a faulty DNA, which is responsible for almost all of the abnormalities. This therapy targeted a specific molecule and silenced it during the course of the disease. Lead rese...

Experimental Drug Deals Effectively with Prostate Cancer Cells

...A, to enter cancer cells, and another type, called silencing RNA// , to stop the expression of a protein that keeps the cells alive, thereby destroying prostate cancer cells leaving normal cells unharmed. The drug, developed at Duke University Medical Center, uses one type of genetic material, called In test...

New Path from Estrogen to Survival in Breast Cancer Cells Described

...uld enhance the survival of breast cancer cells by silencing BCA3, through eliminating its hold on NFkB transcription." Now that this cancer-promoting molecular pathway has been described, Yeh says it might be possible to interfere with a number of the players to inhibit cancer growth. "NEDD8 is key," he sai...

Two Americans Share 2006 Nobel Medicine Prize

...dicine in recognition of their discovery //of gene silencing by double-stranded RNA, it was announced here Monday. The Karolinska Institute cited their discovery of RNA interference in awarding them the 10-million-kronor ($1.37-million) prize. The award winners have discovered "a fundamental mechanism for c...

Nobel Prize – a ‘near miss’ for Indian Scientist coule

...le of RNAi (Ribonucleic acid interference) in gene silencing got the two American scientists the prestigious pr... Missouri, in US had established in 1997 that gene silencing occurs in animal systems. Terming it as a `narrow miss' Dr. Bhadra, who is with the Hyderabad-base...

Nobel Prize for Gene ‘Silencing

...ls and humans. ‘RNA interference’ involves the silencing of DNA by double- stranded RNA.This process plays a vital role in the regulation of gene expression, controls the activity of ‘jumping genes’ or transposons and is involved in the defense mechanism during a viral attack. As is well known, the DNA c...

High Doses of Lithium-Like Drugs May Impair Neuronal Function

...ers inhibited GSK-3 beta using RNA silencing. "RNA silencing allows you to specifically knock down the level of a particular protein inside the cell," Snider said. In a second set of experiments, the researchers treated mouse neurons with a low dose and a high dose of a GSK-3 beta inhibitor similar to lithiu...

Scientists Explore Ways to Reduce Insulin Resistance by ‘handcuffing’ Gens

...itute for Biological Studies, have discovered that silencing a gene for a peptide involved// in insulin secretion will not only reduce insulin resistance, in animal models, it will also help avoid the drawbacks associated with a high calorie diet. The peptide in question is ucocortin 3. This was discovered ...

Estrogen Protects Liver After Traumatic Injury

...n receptor-alpha had no effect on cells, but GPR30 silencing resulted in decreased Bcl-2 and active protein kinase A. By identifying GPR30 and the downstream pathways (Bcl-2 and active protein kinase A) involved in estrogen’s beneficial effects, Chaudry’s group has provided new insights in resolving liver in...

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