Mechanism of Nicotine's Learning Effects Explored
...ered important details of how nicotine adjusts the signaling properties of neuronal wiring to enhance memory. Such signaling properties include the strength of the connections by which one neuron triggers another. Huibert Man...One-fifth of Obese Women Undergo Caesarean Due to Uterus Failure
...bloodstream. This could disrupt cell membranes and signaling pathways, including calcium entry. We will be investigating this further in future studies." Dr Siobhan Quenby from the University of Liverpool's Obstetrics department commented: "In the meantime it is vital pre-pregnancy advice and counseling is ...Understanding of Schizophrenia Could Lead to New Treatment Options
... for the first time, that alterations in NRG1-erbB signaling induce pathologic changes in the brain's white mat...t these changes lead to alterations in biochemical signaling and to behaviors suggestive of mental illness. "We show that causing a defect in white matter is ...Green Tea Compound may Be a Therapy for Rheumatoid Arthritis
...that causes inflammation in the joints. The cell signaling pathways that regulate levels of these immune system molecules under both normal and rheumatoid arthritis situations are well studied, and the researchers were able to trace the effects of the green tea compound infusion to see that it worked by inhi...Life Functions Governed by Circadian Rhythms-new Research
...se. These genes are essential components of leptin signaling system, responsible for the sensation of satiety after eating. The oscillating pattern varies in different organs and determines the effect of leptin on regulation of the energy balance. Better understanding gene oscillation may provide researchers w...Developing Antimetastasis Therapy- An Early Stage of Tumor Control.
...b, lymphatic tissues secrete small quantities of a signaling molecule. Cells migrate towards high concentration...on a stick. Near the vessel, concentrations of the signaling molecule are reinforced by the lymphatics own secretions, fine tuning the tumor cells migration and ...New Developments in Rheumatoid Arthritis
...of older methods. The group has discovered another signaling molecule that seems to increase a persons risk for rheumatoid arthritis by 30 percentIn collaborations with other scientists worldwide, Dr. Gregersen has also been able to show that certain markers are strongly linked to certain ethnic groups and oth...Radical Idea of Implanting Tiny Electrodes to the Deaf
... fibers achieves more precise activation of fibers signaling specific frequencies, reduced electrical current requirements and dramatically reduced interference among electrodes when they are stimulated simultaneously, Middlebrooks says. Middlebrooks has talked with U-M surgeons in otolaryngology about surgi..."Pre-treatment Blood Test" A New Guide to Lung Cancer Therapy
...emotherapy, targeted therapies affect proteins and signaling pathways that are selectively activated in certain malignant cells and not in normal cells. But this selectivity makes these therapies effective only for the subset of patients whose tumors are driven by the targeted pathways. The drawbacks of trea...Brain Inflammation A Friend for Alzheimer's Patients
...ngpin in the realm of inflammation. IL-1 beta, a signaling molecule that promotes brain inflammation, was one of the first molecules that scientists found in higher levels in the brains of people with Alzheimers disease compared to healthy people. Its recognized as a critical player in bringing about much of...Monogram Presents Results of First ETag Breast Cancer Studies
...y enables the eTag technology to accurately assess signaling pathways that control cell growth, proliferation a...idates target various steps in these critical cell signaling pathways, potentially providing an opportunity for the diagnostic capabilities of the eTag technolog...Brain Activity Reflects Variation in Types of Anxiety
...cupied with tracking and responding to information signaling danger. This is the first study, however, to concentrate on the affected regions to classify areas within each hemisphere that seem to matter. Miller stressed the importance of a related finding: The researchers distinguished the left-brain regio...Brain Cells Activity: New Treatment Target for Psychiatric Diseases
... but the exact role of malfunctioning neuregulin-1 signaling was unclear. "(Dr. Mei's) findings help explain ...researchers reported in Nature Medicine an altered signaling pathway for neuregulin-1 and ErbB4 genes in the brains of schizophrenics. Dr. Mei's findings show th...Scientists Report New Take on Sexual Signaling
... Institute in Panama present a new take on sexual signaling in the May issue of the Public Library of Science. The researchers report that females prefer a male sexual signal that helps them avoid their predators as they sequentially visit and assess potential mates. The traditional explanation for the evol...Scientists Use Gene Therapy to Reverse Heart Failure in Animals
...llege, the added S100A1 appears to improve calcium signaling in heart cells, which is critical to the force of contraction of individual cells. In another arm of the study, the scientists looked at the effects of beta-blockers alone or in combination with the S100A1 gene therapy. They found that beta-blocker...Researchers Identify Immune Dysfunction in Melanoma Patients
...ls of normal people. To verify that the interferon signaling was defective in people with melanoma, Critchley-Thorne isolated those cells and exposed them to interferon. As predicted, immune cells from people with melanoma also failed to respond normally to the immune activation signal. However, she found t...Study Revises Dynamin's Role in Nerve Cell Function
...reverse of the process of transmission of cellular signaling chemicals, whereby molecular components of the vesicle are retrieved from the synapse surface and fit back into a new vesicle to be recycled for reuse after the vesicle has discharged its neurotransmitter. One of the steps in this recycling is a bioc...DNA Repair Proteins Monitored at Double-strand Break
...ts in double-strand break repair by disrupting the signaling processes triggered by the break. "A lack of functioning ATM causes ataxia-teleangiectasia, a disease that causes a variety of debilitating problems, such as neurodegeneration, cancer and sensitivity to irradiation leading to double-strand breaks t...Brains White Matter: More Talkative Than Once Thought
...d with myelin. Myelin loss is well known to impair signaling and information processing, causing nerve cells to die and creating such neurodegenerative conditions as multiple sclerosis. Bergles speculates that this white matter activity his team discovered may help naked nerve cells signal nearby OPCs and sa...Cause of Gender Differences in Blood Pressure, Kidney Damage Under Study
...itric oxide synthase, which makes nitric oxide, a signaling molecule that tells smooth muscles cells to relax, may make more nitric oxide in females. Just how active an enzyme is depends on how its phosphorylized, or turned on by adding phosphate groups. Our preliminary data says that the phosphorylation s...